Monitoring diffusion processes in nanoporous block copolymer membranes with high spatial and temporal resolution

以高空间和时间分辨率监测纳米多孔嵌段共聚物膜中的扩散过程

• 批准号: 253503811
• 负责人: Professor Dr. Jürgen Köhler
• 金额: --
• 依托单位: Institut für Organische Chemie und Makromolekulare Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/253503811?language=en
• 关键词: Monitoring; diffusion; processes; nanoporous; block; Monitoring; diffusion; processes; nanoporous; block

The proposed project aims at the investigation of transport processes in switchable diblock copolymer membranes with nanometer-sized pores with high temporal and spatial resolution. The membranes will be prepared by non-solvent induced phase separation (NIPS) from suitable amphiphilic block copolymers which will be synthesized using living/controlled polymerization techniques. The hydrophobic (polystyrene) block will form the matrix of the structures and the hydrophilic segments covers the pore walls. As hydrophilic block we plan to use a material, which solubility in aqueous media can be reversibly altered through external stimuli. Possible envisioned triggers are changes in the pH (e.g., poly(2-dimethylaminoethyl methacrylate), PDMAEMA), temperature (copolymers from PDMAEMA and poly(methyl methacrylate), PMMA), or the irradiation with light of a specific wavelength (copolymers of poly(N-isopropylmethacrylamide), PNiPAAm, and poly(spiropyrane methacrylate), PSPMA). The transport processes will be monitored using 3D single particle optical tracking (3D-SPOT) with fluorescently labeled particles of suitable size (d < 50 nm). The recorded diffusion paths will be compared with reconstructed 3D models of membranes by transmission electron microscopy tomography (TEMT) using semi-thin microtome slices (200-300 nm). Prior to that, the membranes will be embedded within suitable resins.

拟议的项目旨在研究具有纳米尺寸孔具有高时空和空间分辨率的可切换二嵌段共聚物膜中的运输过程。该膜将通过合适的两亲性块共聚物的非溶剂诱导相分离（NIP）制备，这些分离（NIP）将使用生活/受控聚合技术合成。疏水（聚苯乙烯）块将形成结构的基质，而亲水性片段覆盖了孔隙壁。作为亲水性阻滞，我们计划使用一种材料，在水性培养基中的溶解度可以通过外部刺激可逆地改变。 Possible envisioned triggers are changes in the pH (e.g., poly(2-dimethylaminoethyl methacrylate), PDMAEMA), temperature (copolymers from PDMAEMA and poly(methyl methacrylate), PMMA), or the irradiation with light of a specific wavelength (copolymers of poly(N-isopropylmethacrylamide), PNiPAAm, and poly(spiropyrane甲基丙烯酸酯），PSPMA）。将使用3D单粒子光学跟踪（3D点）对传输过程进行监测，并具有荧光标记的合适尺寸（d <50 nm）的颗粒。使用半薄的微型片切片（200-300 nm），将通过透射电子显微镜断层扫描（TEMT）（200-300 nm）将记录的扩散路径与重建的3D膜3D模型进行比较。在此之前，膜将嵌入合适的树脂中。