CAREER: Multi-channel, Sub-microliter Implants for Selective Neuromodulation

职业：用于选择性神经调节的多通道、亚微升植入物

• 批准号: 2236238
• 负责人: Benjamin Johnson
• 金额: $ 52.12万
• 依托单位: Boise State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2236238&HistoricalAwards=false
• 关键词: CAREER; Multi; channel; Sub; microliter; CAREER; Multi; channel; Sub; microliter

Bioelectronic medicine can revolutionize how we practice medicine in offering effective non-opioid pain management, and providing compelling alternatives to other pharmaceuticals for conditions such as epilepsy, traumatic brain injury, high blood pressure, rheumatoid arthritis, sleep apnea, urinary incontinence, and treatment-resistant depression. Bioelectronic medicines are neurotechnology devices that read and modulate the electrical activity of the body’s nervous system to control, regulate, or restore function. Medical care that uses these devices to continuously monitor physiological biomarkers and autonomously deliver therapy will significantly reduce clinician burden, improve patient compliance, and reduce adverse drug reactions and abuse. However, current bioelectronic medicine devices are too large to target small nerves for effective therapy, deliver indiscriminate stimulation on large nerves resulting in significant off-target effects, and lack the sophistication for closed-loop, automated processing. This project will address these issues through key innovations in circuit design, system development, and closed-loop control. Project impact is extended through a multi-tiered education initiative to bolster the local semiconductor and neurotechnology workforce with collaboration from industry experts.This project will develop a wireless, miniaturized neurotechnology interface that selectively records and stimulates from specific fascicles within a larger nerve. The proposed work will make advances in three areas. First, the project will develop and validate a new stimulation technique that significantly reduces the volume of an implant and improves its safety and reliability regardless of electrode size. Second, the project will develop a new bi-directional wireless link that exceeds state-of-the-art efficiencies by co-design recording, stimulation, and wireless circuitry. Lastly, the project will use this new interface to evaluate machine learning optimization systems in a closed-loop experiment that targets specific nerve fascicles in the sciatic nerve of an animal model.This project is jointly funded by ECCS and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物电子医学可以彻底改变我们在提供有效的非阿片类药物疼痛管理方面进行医学的方式，并为其他药物提供令人信服的替代品，以示癫痫，创伤性脑损伤，高血压，类风湿关节炎，睡眠呼吸暂停，尿液无关，尿液无关和治疗耐药的抑郁症。生物电子药物是神经技术设备，可读取和调节人体神经系统的电活动以控制，调节或恢复功能。使用这些设备不断监测生理生物标志物并自主提供治疗的医疗保健将大大减少临床燃烧，改善患者的依从性并减少不良药物反应和滥用。但是，当前的生物电机设备太大，无法针对小神经，无法进行有效的治疗，对大神经提供不加区分的刺激，从而产生明显的脱靶效应，并且缺乏闭环，自动化处理的社会化。该项目将通过电路设计，系统开发和闭环控制方面的关键创新来解决这些问题。通过一项多层教育计划来扩大项目影响，以加强本地半导体和神经技术的劳动力与行业专家的合作。该项目将开发一个无线化的微型神经技术界面，有选择地记录并刺激较大神经内的特定界面。拟议的工作将在三个领域取得进步。首先，该项目将开发并验证一种新的刺激技术，该技术可显着减少植入物的体积并提高其安全性和可靠性，而不论电极大小如何。其次，该项目将开发出一个新的双向无线链路，该链接通过共同设计，刺激和无线电路超过最先进的效率。最后，该项目将在闭环实验中使用这种新界面来评估机器学习优化系统，该实验针对动物模型的坐骨神经中的特定神经筋膜。该项目由ECCS共同资助，而既定的计划则启动了竞争性研究（EPSCOR）（EPSCOR），这反映了NSF的众多奖励，这反映了NSF的众多范围，并在其范围内得到了良好的支持。 标准。