ISS: Plasmonic Bubble Enabled Nanoparticle Deposition under Micro-Gravity

ISS：微重力下等离子气泡实现纳米颗粒沉积

• 批准号: 2224307
• 负责人: Tengfei Luo
• 金额: $ 72.62万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2224307&HistoricalAwards=false
• 关键词: ISS; Plasmonic; Bubble; Enabled; Nanoparticle

Novel technologies that are simple and cost-effective for fabricating highly sensitive biosensors may significantly benefit a wide range of important applications, such as early detection of epidemic/pandemic infectious disease, cancers, and other biological agents. A major challenge for such detection is the low concentration of the target molecules. This project will leverage the fluid flow around a thermal bubble on a surface, concentrating and depositing the target molecules in the liquid sample, to enhance their detectability. The PI will perform microgravity experiments at the International Space Station to investigate the concentration/deposition processes, which will enable the development of improved sensing techniques for disease detection, cancer diagnosis and environmental monitoring. Given the potential transformative impacts for terrestrial applications, this project is aligned with the mission of CASIS to leverage space research to benefit life on earth. This research project will also educate and train graduate and undergraduate students from under-represented groups at Notre Dame. Through this project, the PI will cultivate a future workforce for the U.S. manufacturing and healthcare industries. The PI will also outreach to the local high schools and participate in local area science events to extend the outreach of this project. This project aims to understand the flow phenomena around a thermal bubble generated on a surface by a laser excitation. The flow pattern around the bubble can collect and eventually deposit colloidal particles in the liquid onto the surface. The overarching goal of this project is to understand the flow and deposition mechanism in order to control the deposition of suspended particles and thus enable new technologies for sensing applications. The PI will combine the microgravity experiments in the ISS and comparative terrestrial experiments complemented by multi-physics modeling to achieve this understanding. The micro-gravity environment in the ISS will provide a unique platform to unlock the fundamental mechanism of bubble nucleation, growth, and detachment. The lack of thermal convection in the ISS will allow the decoupling of the contribution of Marangoni effect from thermal convection effect to elucidate their roles in collecting colloidal particles and depositing them on the surface. This research will improve the understanding of the fundamental opto-thermal-fluidic mechanism of the thermal bubble deposition process, which will contribute to advancing the fields of nanoscale interactions, thermofluids and biosensing. This research project will also educate and train graduate and undergraduate students from under-represented groups at Notre Dame. Through this project, the PI will cultivate a future workforce for the U.S. manufacturing and healthcare industries. The PI will also outreach to the local high schools and participate in local area science events to extend the outreach of this project.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

对于制造高度敏感的生物传感器而言，简单且具有成本效益的新型技术可能会显着受益于广泛的重要应用，例如早期发现流行/大流行感染性疾病，癌症和其他生物学剂。这种检测的主要挑战是目标分子的低浓度。该项目将利用表面上的热气泡周围的流体流动，将靶分子集中并沉积在液体样品中，以增强其可检测性。 PI将在国际空间站进行微重力实验，以研究浓度/沉积过程，这将能够开发改进的疾病检测，癌症诊断和环境监测的感应技术。鉴于对地面应用的潜在变革性影响，该项目与Casis的使命一致，以利用太空研究来使地球上的生命受益。该研究项目还将在巴黎圣母院（Notre Dame）教育和培训毕业生和本科生。通过该项目，PI将为美国制造业和医疗保健行业培养未来的劳动力。 PI还将向当地高中推广，并参加本地科学活动，以扩大该项目的宣传。该项目旨在了解激光激发在表面产生的热气泡周围的流动现象。气泡周围的流动模式可以收集并最终将胶体颗粒沉积在液体上。该项目的总体目标是了解流动和沉积机制，以控制悬浮颗粒的沉积，从而实现用于传感应用的新技术。 PI将结合ISS中的微重力实验和比较陆地实验，并通过多物理建模互补，以实现这一理解。国际空间站中的微夺取环境将提供一个独特的平台，以解锁气泡成核，生长和脱离的基本机制。 ISS中缺乏热对流将允许将Marangoni效应从热对流效应中脱成贡献，以阐明其在收集胶体颗粒并将其沉积在表面上的作用。这项研究将提高对热气泡沉积过程的基本光热富富机制的理解，这将有助于推进纳米级相互作用，热流体和生物传感的领域。该研究项目还将在巴黎圣母院（Notre Dame）教育和培训毕业生和本科生。通过该项目，PI将为美国制造业和医疗保健行业培养未来的劳动力。 PI还将向当地高中推广，并参加本地科学活动，以扩大该项目的宣传。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的评估审查标准来通过评估来获得支持的。

项目成果

Analytical model of optical force on supercavitating plasmonic nanoparticles

超空泡等离子体纳米颗粒的光学力分析模型

• DOI: 10.1364/oe.491699
• 发表时间: 2023
• 期刊: Optics Express
• 影响因子: 3.8
• 作者: Mandal, Amartya;Lee, Eungkyu;Luo, Tengfei
• 通讯作者: Luo, Tengfei