MRI: Acquisition of a laser scanning confocal microscope for use in research and teaching in the Biology, Chemistry and Physics Departments at Grinnell College

MRI：购买激光扫描共焦显微镜，用于格林内尔学院生物、化学和物理系的研究和教学

• 批准号: 2216359
• 负责人: Clark Lindgren
• 金额: $ 49.96万
• 依托单位: Grinnell College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216359&HistoricalAwards=false
• 关键词: MRI; Acquisition; laser; scanning; confocal

An award is made to Grinnell College to purchase a point-scanning confocal microscope system. Grinnell College has been an active participant and leader in efforts to improve science pedagogy by incorporating active learning techniques into the classroom, improving access to science for women and underrepresented groups, and integrating research experiences throughout the curriculum. This instrument will support these efforts by providing new research possibilities for faculty and their students, both in the research lab and in existing laboratory courses. Beyond this, the investigators will create and teach a new course dedicated to microscopy techniques. More specifically, they will incorporate the proposed instrument into an existing program that provides educational opportunities for inmates at a nearby medium security prison. Further, the co-PIs propose the development of a workshop for regional liberal arts colleges, to be hosted at Grinnell, the aim of which is to exchange best practices and work together to design experiments using fluorescence microscopy and/or confocal microscopy that are accessible to undergraduate students in a variety of settings. This award will support a range of research and teaching/training activities in biology, biochemistry, chemistry, and physics including: (1) studying synaptic plasticity at the neuromuscular junction (NMJ); (2) detecting microtubule formation below the diffraction limit of light; (3) characterizing neurovascular patterning and guidance in the developing vertebrate heart; (4) deciphering the genetic control of Ca2+ levels in cell migration; (5) characterizing the spatiotemporal activity of various proteins in regulating mitotic spindle function; and (6) detecting allosteric conformational changes in nicotinic acetylcholine receptors. This award will enable Grinnell College faculty and students to address questions that are beyond their current capability. The results will be disseminated in publications in peer-reviewed journals and in presentations at scientific conferences throughout the world.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

授予格林内尔学院（Grinnell College）颁发奖励，以购买点扫描的共聚焦显微镜系统。格林内尔学院（Grinnell College）一直是通过将积极的学习技术纳入课堂，改善女性和代表性不足的群体的科学访问，并整合整个课程的研究经验，从而改善了科学的访问，以改善科学教育学的努力。该工具将在研究实验室和现有实验室课程中为教师及其学生提供新的研究可能性来支持这些努力。除此之外，研究人员还将创建并教授专门针对显微镜技术的新课程。更具体地说，他们将将拟议的工具纳入现有的计划中，该计划为附近的中型安全监狱提供教育机会。此外，Co-Pis提出了为格林内尔举办的区域文科学院研讨会的开发，其目的是交换最佳实践并共同努力，共同设计实验，使用荧光显微镜和/或共斑显微镜检查，这些实验可在各种环境中访问本科生。该奖项将支持生物学，生物化学，化学和物理学的一系列研究和教学活动，包括：（1）在Neuromuscular Junction（NMJ）研究突触可塑性； （2）检测在光的衍射极限以下的微管形成； （3）表征发育中的脊椎动物心脏中的神经血管图案和指导； （4）破译细胞迁移中Ca2+水平的遗传控制； （5）表征各种蛋白在调节有丝分裂纺锤体功能方面的时空活性； （6）检测烟碱乙酰胆碱受体的变构构象变化。该奖项将使格林内尔学院的教职员工和学生能够解决超出其当前能力的问题。该结果将在同行评审期刊的出版物和全球科学会议上的演讲中传播。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子和更广泛影响的评估标准来通过评估来获得支持的。