SBIR Phase I: A Portable Oxygen Concentrator with High Flow Rates for In-home Therapy (COVID-19)

SBIR 第一阶段：用于家庭治疗的高流量便携式制氧机 (COVID-19)

• 批准号: 2136709
• 负责人: Jun Kamata
• 金额: $ 25.6万
• 依托单位: AIROMATIX INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2136709&HistoricalAwards=false
• 关键词: SBIR; Phase; Portable; Oxygen; Concentrator

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to enable easy oxygen delivery to patients with respiratory conditions. Currently, patients requiring high flow-rates of oxygen above 4 L/min require oxygen tanks that are large, heavy and can be hazardous, limiting mobility and transportation options. The proposed system produces breathable oxygen at higher flow rates and lower energy compared to current portable oxygen concentrators, enabling sustained patient use. This enables sustained oxygen production in a portable manner to manage medical conditions causing oxygen deprivation, including Chronic Obstructive Pulmonary Disease (COPD) and Coronavirus Disease (COVID-19). This Small Business Innovation Research (SBIR) Phase I project will develop a portable system that utilizes a novel photocatalytic (light activated) reaction to separate oxygen from ambient air, trapped in a chemical solution, then released as needed through a temperature-controlled reaction. This project will monitor the capture and release reactions using absorption spectroscopy to determine the ideal conditions of oxygen production. Several photosensitizer chemical compounds (fullerene C70 and C60, rubrene, and methylene blue with urea) will be evaluated on system longevity by continuously cycling the systems under higher temperatures and light exposure, and monitoring their effects on oxygen production. A prototype will then be developed that generates targeted oxygen flow rates at the desired rate of energy consumption, and the oxygen produced validated as safe for inhalation using bench tests.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小企业创新研究 (SBIR) 第一阶段项目的更广泛影响/商业潜力是为患有呼吸系统疾病的患者提供轻松的氧气输送。 目前，需要高于 4 升/分钟的高流量氧气的患者需要的氧气罐又大又重，而且可能很危险，限制了行动和运输选择。与目前的便携式制氧机相比，所提出的系统以更高的流速和更低的能量产生可呼吸的氧气，从而使患者能够持续使用。这使得能够以便携式方式持续产生氧气，以管理导致缺氧的医疗状况，包括慢性阻塞性肺病（COPD）和冠状病毒病（COVID-19）。该小型企业创新研究 (SBIR) 第一阶段项目将开发一种便携式系统，利用新型光催化（光激活）反应从环境空气中分离出氧气，捕获在化学溶液中，然后通过温控反应根据需要释放氧气。该项目将利用吸收光谱监测捕获和释放反应，以确定氧气产生的理想条件。将通过在较高温度和光照下连续循环系统并监测其对氧气产生的影响，评估几种光敏剂化合物（富勒烯 C70 和 C60、红荧烯和亚甲蓝与尿素）的系统寿命。然后将开发一个原型，以所需的能量消耗率产生目标氧气流量，并通过台架测试验证所产生的氧气可以安全吸入。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准。