RUI: Development of Next-Generation Drift-Time Ion Mobility Spectrometry through the Application of Pulsed Ionization and Voltage Sweep Methodologies

RUI：通过应用脉冲电离和电压扫描方法开发下一代漂移时间离子淌度光谱法

• 批准号: 2203666
• 负责人: Eric Davis
• 金额: $ 31万
• 依托单位: Whitworth University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2203666&HistoricalAwards=false
• 关键词: RUI; Development; Next; Generation; Drift

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Eric Davis and his group at Whitworth University are working to improve the capabilities of ion mobility spectrometry (IMS), a chemical measurement technique commonly used in security and military applications for the detection of explosives, narcotics, and chemical warfare agents. The Davis group seeks to expand the usefulness of IMS by improving its ability to separate complex, real-world mixtures rapidly. The research is primarily performed by Whitworth undergraduate students under the supervision of Professor Davis. Through collaboration with Brian H. Clowers at Washington State University, Dr. Davis' students are exposed to the graduate school environment, helping to better prepare them to pursue graduate studies. Research opportunities also expand into the local community of analytical chemists within the greater Spokane, WA area, bringing together industrial and academic chemists for the mutual benefit of students and the community.Prior efforts in creating voltage sweep (VS) IMS separations have utilized either stepped-potential or multiplexed VS methods that do not attain the high-resolution or high-speed separations required for many IMS applications. Utilization of printed circuit board-based IMS cells (with minimal circuit tracing to reduce capacitance) and application of high voltage amplifiers (capable of 500 V/ms slew rates) enable single-run VSIMS methods which can provide significant improvements in IMS resolution and peak capacity. Parasitic losses of ions through the gating process under low-field conditions can be mitigated through use of pulsed ionization sources and elimination of the ion gate. Primary aims are to (1) develop a single-run VSIMS method using high voltage amplifiers to allow high resolution, high peak capacity IMS separations; (2) evaluate the utility of pulsed ionization sources with both IMS and mass spectrometry (MS) with respect to ion formation, kinetics, and speciation; and (3) utilize pulsed sources in IMS separations to avoid gate depletion effects under low-field voltage sweep conditions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学测量和成像项目的支持下，惠特沃斯大学的 Eric Davis 和他的团队正在努力提高离子迁移谱 (IMS) 的能力，这是一种常用于安全和军事应用的化学测量技术。爆炸物、麻醉品和化学战剂的检测。戴维斯小组寻求通过提高 IMS 快速分离复杂的现实混合物的能力来扩大 IMS 的实用性。该研究主要由惠特沃斯本科生在戴维斯教授的监督下进行。 通过与华盛顿州立大学的 Brian H. Clowers 合作，戴维斯博士的学生可以接触研究生院环境，帮助他们更好地为攻读研究生做好准备。研究机会还扩展到华盛顿州斯波坎大区的当地分析化学家社区，将工业和学术化学家聚集在一起，以实现学生和社区的共同利益。创建电压扫描 (VS) IMS 分离的先前努力已利用了任一步骤-无法实现许多 IMS 应用所需的高分辨率或高速分离的潜在或多路 VS 方法。利用基于印刷电路板的 IMS 单元（采用最少的电路跟踪以减少电容）和高压放大器（能够实现 500 V/ms 转换速率）的应用可实现单次运行 VSIMS 方法，从而显着提高 IMS 分辨率和峰值容量。通过使用脉冲电离源和消除离子门，可以减轻低场条件下门控过程中离子的寄生损失。主要目标是 (1) 开发一种使用高压放大器的单次 VSIMS 方法，以实现高分辨率、高峰值容量 IMS 分离； (2) 评估脉冲电离源与 IMS 和质谱 (MS) 在离子形成、动力学和形态形成方面的效用； (3) 在 IMS 分离中利用脉冲源，以避免低场电压扫描条件下的栅极耗尽效应。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。