Towards understanding long-term cartilage degeneration: The role of passive joint laxity and active joint instability in pathological knee kinematics

理解长期软骨退变：被动关节松弛和主动关节不稳定在膝关节病理运动学中的作用

• 批准号: 250903318
• 负责人: Professor Dr.-Ing. Georg Duda
• 金额: --
• 依托单位: Julius Wolff Institut für Biomechanik und Muskuloskeletale Regeneration (CVK)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/250903318?language=en
• 关键词: Towards; understanding; long; term; cartilage

Instability of the knee joint is thought to be a precursor to osteoarthritis (OA) due to excessive rotation and shear movement within the joint. The relationship between static joint laxity and dynamic movement patterns remains unclear, but such knowledge is essential to understand the contribution of joint laxity towards osteoarthritic degeneration of the knee joint. If available, such understanding could allow a standard assessment metric for early recognition of joint degeneration to be attained. By specifically assessing the components of tibio-femoral motion that affect cartilage degeneration, it could also be possible to inform on preventive and therapeutical measures to target specific stabilisation of the joint for reducing the rate of osteoarthritic degeneration. The goal of this study is therefore to identify the components of passive joint laxity that best correlate with kinematic and kinetic parameters, and later to determine their role in the progression of gonarthrosis after knee injury. Through combining knowledge of the internal loading conditions within the knee joint with the measurement and identification of tibio-femoral shear and rotational movement during standardised activities of daily living using advanced motion analysis techniques, this project aims to elucidate the specific contribution of the mechanical aspects of anterior-posterior translation and rotational laxity of the joint towards the onset of gonarthrosis. This study therefore provides a key basis for 1) science based measures to prevent injury through specifically training joint stability, 2) assessing the requirement for surgical intervention, 3) guiding intra-operative strategies for joint stabilisation and 4) helping postoperative physiotherapy in targeting muscular components for strengthening and stabilisation.

由于关节内过度旋转和剪切运动，膝关节不稳定被认为是骨关节炎 (OA) 的先兆。静态关节松弛和动态运动模式之间的关系仍不清楚，但这些知识对于理解关节松弛对膝关节骨关节炎退化的影响至关重要。如果可行的话，这种理解可以实现早期识别关节退化的标准评估指标。通过专门评估影响软骨退变的胫骨-股骨运动的组成部分，还可以提供预防和治疗措施，以实现关节的特定稳定，从而降低骨关节炎退变的发生率。因此，本研究的目的是确定与运动学和动力学参数最相关的被动关节松弛的组成部分，并随后确定它们在膝关节损伤后膝关节病进展中的作用。通过将膝关节内部负载条件的知识与使用先进的运动分析技术在日常生活标准化活动中测量和识别胫骨-股骨剪切和旋转运动相结合，该项目旨在阐明膝关节机械方面的具体贡献关节的前后平移和旋转松弛导致膝关节炎的发生。因此，这项研究为以下方面提供了关键基础：1）通过专门训练关节稳定性来采取基于科学的措施来预防损伤；2）评估手术干预的需求；3）指导术中关节稳定策略；4）帮助术后物理治疗针对肌肉用于强化和稳定的组件。

项目成果

Towards understanding knee joint laxity: errors in non-invasive assessment of joint rotation can be corrected.

理解膝关节松弛：可以纠正关节旋转非侵入性评估中的错误

• DOI: 10.1016/j.medengphy.2014.03.017
• 发表时间: 2014
• 期刊: Medical engineering & physics
• 影响因子: 2.2
• 作者: P. Moewis; H. Boeth; M. O. Heller; C. Yntema; T. Jung; R. Doyscher; R.M. Ehrig; Y. Zhong; W.R. Taylor
• 通讯作者: W.R. Taylor

Association between changes in molecular biomarkers of cartilage matrix turnover and changes in knee articular cartilage: a longitudinal pilot study

软骨基质周转的分子生物标志物变化与膝关节软骨变化之间的关联：纵向试点研究

• DOI: 10.1186/s40634-019-0179-3
• 发表时间: 2019
• 期刊: Journal of Experimental Orthopaedics
• 影响因子: 1.8
• 作者: Boeth; Heide;Raffalt; Peter C.;MacMahon; Aoife;Poole; A. Robin;Eckstein; Feli;Wirth; Wolfgang;Buttgereit; Frank;Önnerfjord; Patrik;Lorenzo; Pilar;Klint; Cecilia;Pramhed; Anna;Duda; Georg N.
• 通讯作者: Georg N.

Real-Time Nonlinear Shape Interpolation

实时非线性形状插值

• DOI: 10.1145/2729972
• 发表时间: 2015-05-08
• 期刊: ACM Transactions on Graphics (TOG)
• 作者: C. V. Tycowicz;Christian Schulz;H. Seidel;K. Hildebr;t;t
• 通讯作者: t

MRI findings of knee abnormalities in adolescent and adult volleyball players

青少年和成年排球运动员膝盖异常的 MRI 结果

• DOI: 10.1186/s40634-017-0080-x
• 发表时间: 2017-12
• 期刊: Journal of Experimental Orthopaedics
• 影响因子: 1.8
• 作者: Boeth H;MacMahon A;Eckstein F;Diederichs G;Schlausch A;Wirth W;Duda GN
• 通讯作者: Duda GN

The Restoration of Passive Rotational Tibio-Femoral Laxity after Anterior Cruciate Ligament Reconstruction

前十字韧带重建后被动旋转胫股骨松弛的恢复

• DOI: 10.1371/journal.pone.0159600
• 发表时间: 2016
• 期刊: PLoS ONE
• 影响因子: 3.7
• 作者: Moewis P;Duda GN;Jung T;Heller MO;Boeth H;Kaptein B;Taylor WR
• 通讯作者: Taylor WR