STTR Phase I: A mesh-free, sling-free, minimally invasive treatment for stress urinary incontinence in women

STTR 第一期：无网、无吊带的微创治疗女性压力性尿失禁

• 批准号: 2127552
• 负责人: Ghazaleh Rostami Nia
• 金额: $ 25.6万
• 依托单位: ALTYX SURGICAL, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2022-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2127552&HistoricalAwards=false
• 关键词: STTR; Phase; mesh; free; sling

The broader impact/commercial potential of this Small Business Technology Transfer Program (STTR) Phase I project is to advance a new women's health device to address stress urinary incontinence (SUI). The estimated lifetime risk of urinary incontinence surgery in women is 20% by age 80, with 41.3 million women estimated to suffer from urinary incontinence by 2050. The associated market had an estimated value of $1.6 billion in 2018, with projections to reach $2.3 billion by 2026. The proposed device addresses this need and improves clinical outcomes. This Small Business Technology Transfer Program (STTR) Phase I project aims to demonstrate the mechanical feasibility of a non-mesh surgical device by developing the first viable prototype and iterating elements of the device design based on mechanical tests (strength, stiffness, and durability) of each of the device’s components (i.e., the elastic band, the tissue anchor, and the bone anchor) and the device as a whole. The technical objectives include using computational simulations to assess the material stiffness and optimize placement, preparing and testing materials, and ensuring strength and longevity of the assembled device.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小型企业技术转移计划（STTR）I阶段项目的更广泛的影响/商业潜力是推进新的女性健康设备，以解决压力尿失禁（SUI）。到80岁时，女性尿失禁手术的终身风险估计为20％，到2050年，估计有4,130万妇女遭受尿失禁。2018年，相关市场的价值为16亿美元，到2026年，项目的项目将达到23亿美元。拟议的设备解决了这一需求，并提高了临床库存。这个小型企业技术转移计划（STTR）I阶段项目旨在通过开发基于机械测试（强度，刚度和耐用性）的设备设计的第一个可行原型和设备设计的迭代元素来证明非网状手术设备的机械性，并且设备的每个组件（即，弹性带，弹性带，骨骼锚定）以及设备锚定）以及一个设备锚定）。技术对象包括使用计算模拟来评估材料刚度并优化放置，准备和测试材料，并确保组装设备的力量和寿命。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛影响的审查标准通过评估来评估的支持。