QLCI-CI: NSF Quantum Leap Challenge Institute for Quantum Sensing in Biophysics and Bioengineering

QLCI-CI：NSF 量子飞跃挑战生物物理和生物工程量子传感研究所

• 批准号: 2121044
• 负责人: Gregory Engel
• 金额: $ 2500万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2121044&HistoricalAwards=false
• 关键词: QLCI; CI; NSF; Quantum; Leap; QLCI; CI; NSF; Quantum; Leap

Quantum sensing has the potential to revolutionize understanding of the inner workings—the molecular underpinnings—of biology and human health. Quantum sensing will allow probing the physical properties of biological systems with nanometer resolution and single-molecule sensitivity, resolving the microscopic relationships among ions, molecules, cells, and tissues while also elucidating dynamics. The Institute for Quantum Sensing in Biophysics and Bioengineering will create new types of biocompatible quantum sensors and embed these quantum sensors within biological systems to extract new information and gain control over biological processes that, until now, have been beyond reach. The Institute brings together researchers from materials science, physics, chemistry, engineering, biology, and medicine working side-by-side at every step to define and tackle these manifestly interdisciplinary challenges.The Institute will train the future quantum technology workforce by creating a Quantum Academy (for K-12) and Quantum Institute (post-secondary workforce training). These programs will work with underserved communities within Chicago, exposing students to quantum science and training teachers in the development of quantum science curriculum. These programs seek to show students not only the material, but also the scientific process, to help them understand quantum science and see themselves as scientists. The programs also will match trainees with potential employers in quantum technology fields.The Quantum Leap Challenge Institute for Quantum Sensing in Biophysics and Bioengineering will develop biocompatible quantum materials, establish protocols for quantum sensing and imaging within cells, and demonstrate the utility of quantum measurements in biology and medicine. The research is focused on four thrusts. In the sensing thrust, this project will define novel biocompatible probes to enable quantum measurements that are correlated in time and/or space. In the biological targeting thrust, material compatibility and biochemical specific targeting will be ensured, and sensing protocols will be developed to overcome issues related to integrating quantum sensors into living cells. In the correlative imaging thrust, the Institute will develop controlled test cases, image processing techniques, and reconstruction tools that exploit both classical and quantum correlations for imaging biological systems. Importantly, these three thrusts are tightly connected to a fourth thrust centered on biophysical and biological grand challenges to help image dynamics in ion channels, force networks, bioelectricity, and cellular communication.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

量子敏感性有可能改变生物学和人类健康的内部工作（分子基础）的理解。量子灵敏度将允许探测具有纳米分辨率和单分子灵敏度的生物系统的物理性质，从而解决离子，分子，细胞和组织之间的微观关系，同时阐明动力学。生物物理学和生物工程中的量子传感研究所将创建新型的生物相容性量子传感器，并将这些量子传感器嵌入生物学系统中，以提取新信息并对到目前为止的生物学过程获得新的控制。该研究所将研究人员汇集了材料，物理，化学，工程，生物学和医学的研究人员，并在每一步并排工作，以定义和应对这些明显的跨学科挑战。该研究所将通过创建量子学院（For K-12）和量子研究所（Eccondum Institute）（Eccondum Institute）（Eccondum toelferce培训）来培训未来的量子技术劳动力。这些计划将与芝加哥境内服务不足的社区合作，使学生在开发量子科学课程方面接受量子科学和培训老师。这些计划旨在向学生展示材料，而且还向科学过程展示，以帮助他们理解量子科学并将自己视为科学家。该计划还将与量子技术领域的潜在雇主相匹配。量子LEAP挑战研究所的生物物理学和生物工程技术将开发生物相容性的量子材料，为细胞内的量子灵敏度和成像建立协议，并证明生物学和药物中量子测量的实用性。该研究的重点是四个推力。在感应推力中，该项目将定义新的生物相容性问题，以实现与时间和/或空间相关的量子测量。在生物学靶向推力中，将确保材料兼容性和生化特异性靶向，并将开发传感器以克服与将量子传感器集成到活细胞中有关的问题。在正确的成像推力中，研究所将开发受控的测试用例，图像处理技术和重建工具，以利用对生物系统成像的经典和量子相关性。重要的是，这三个推力与以生物物理和生物学宏大的挑战为中心，以帮助离子频道，力网络，生物电力和蜂窝沟通的图像动态的第四个推力，这反映了NSF的法规任务，并认为通过基金会的知识优点和广泛的cribity crietia criperia criperia criperia criperia the Issportion the Pociess the Iss the Iss the奖项。