QLCI-CI: NSF Quantum Leap Challenge Institute for Quantum Sensing in Biophysics and Bioengineering

QLCI-CI：NSF 量子飞跃挑战生物物理和生物工程量子传感研究所

基本信息

批准号：
2121044
负责人：
Gregory Engel
金额：
$ 2500万
依托单位：
University of Chicago
依托单位国家：
美国
项目类别：
Cooperative Agreement
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-08-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2121044&HistoricalAwards=false
关键词：
QLCI CI NSF Quantum Leap

项目摘要

Quantum sensing has the potential to revolutionize understanding of the inner workings—the molecular underpinnings—of biology and human health. Quantum sensing will allow probing the physical properties of biological systems with nanometer resolution and single-molecule sensitivity, resolving the microscopic relationships among ions, molecules, cells, and tissues while also elucidating dynamics. The Institute for Quantum Sensing in Biophysics and Bioengineering will create new types of biocompatible quantum sensors and embed these quantum sensors within biological systems to extract new information and gain control over biological processes that, until now, have been beyond reach. The Institute brings together researchers from materials science, physics, chemistry, engineering, biology, and medicine working side-by-side at every step to define and tackle these manifestly interdisciplinary challenges.The Institute will train the future quantum technology workforce by creating a Quantum Academy (for K-12) and Quantum Institute (post-secondary workforce training). These programs will work with underserved communities within Chicago, exposing students to quantum science and training teachers in the development of quantum science curriculum. These programs seek to show students not only the material, but also the scientific process, to help them understand quantum science and see themselves as scientists. The programs also will match trainees with potential employers in quantum technology fields.The Quantum Leap Challenge Institute for Quantum Sensing in Biophysics and Bioengineering will develop biocompatible quantum materials, establish protocols for quantum sensing and imaging within cells, and demonstrate the utility of quantum measurements in biology and medicine. The research is focused on four thrusts. In the sensing thrust, this project will define novel biocompatible probes to enable quantum measurements that are correlated in time and/or space. In the biological targeting thrust, material compatibility and biochemical specific targeting will be ensured, and sensing protocols will be developed to overcome issues related to integrating quantum sensors into living cells. In the correlative imaging thrust, the Institute will develop controlled test cases, image processing techniques, and reconstruction tools that exploit both classical and quantum correlations for imaging biological systems. Importantly, these three thrusts are tightly connected to a fourth thrust centered on biophysical and biological grand challenges to help image dynamics in ion channels, force networks, bioelectricity, and cellular communication.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

量子传感有可能彻底改变对生物学和人类健康的内部运作（分子基础）的理解。量子传感将允许以纳米分辨率和单分子灵敏度探测生物系统的物理特性，解决离子、分子、细胞和组织，同时阐明动力学。生物物理学和生物工程量子传感研究所将创建新型生物相容性量子传感器，并将这些量子传感器嵌入生物系统中以提取。该研究所汇集了材料科学、物理、化学、工程、生物学和医学领域的研究人员，在每一步中并肩工作，以定义和解决这些问题。这些明显的跨学科挑战。该研究所将通过创建量子学院（针对 K-12）和量子研究所（高等教育劳动力培训）来培训未来的量子技术劳动力。这些项目将与芝加哥服务不足的社区合作，让学生接触量子技术。量子发展中的科学和培训教师这些项目不仅旨在向学生展示材料，还向他们展示科学过程，以帮助他们了解量子科学并将自己视为科学家。这些项目还将为学员与量子技术领域的潜在雇主进行匹配。生物物理和生物工程量子传感研究所将开发生物相容性量子材料，建立细胞内量子传感和成像协议，并展示量子测量在生物学和医学中的实用性。该研究重点关注传感方面的四个重点。项目将定义新型生物相容性探针能够在生物靶向推力中实现与时间和/或空间相关的量子测量，将确保材料兼容性和生化特异性靶向，并且将开发传感协议以克服与将量子传感器集成到活细胞中相关的问题。在相关成像主旨中，该研究所将开发受控测试用例、图像处理技术和重建工具，利用经典和量子相关性对生物系统进行成像。重要的是，这三个主旨与以生物物理和生物为中心的第四个主旨紧密相连。助力影像动态的重大挑战该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Leveraging Dynamical Symmetries in Two-Dimensional Electronic Spectra to Extract Population Transfer Pathways

利用二维电子光谱中的动态对称性来提取种群转移路径

DOI：
10.1021/acs.jpca.2c01993
发表时间：
2022
期刊：
The Journal of Physical Chemistry A
影响因子：
0
作者：
Higgins, Jacob S.;Dardia, Anna R.;Ndife, Chidera J.;Lloyd, Lawson T.;Bain, Elizabeth M.;Engel, Gregory S.
通讯作者：
Engel, Gregory S.

Exciton-Condensate-Like Amplification of Energy Transport in Light Harvesting

光收集中能量传输的类激子凝聚放大

DOI：
10.1103/prxenergy.2.023002
发表时间：
2023
期刊：
PRX Energy
影响因子：
0
作者：
Schouten, Anna O.;Sager-Smith, LeeAnn M.;Mazziotti, David A.
通讯作者：
Mazziotti, David A.

Observation of topological action potentials in engineered tissues

DOI：
10.1038/s41567-022-01853-z
发表时间：
2022-12
期刊：
Nature Physics
影响因子：
19.6
作者：
Hillel Ori;Marc Duque;Rebecca Frank Hayward;Colin Scheibner;He Tian;Gloria Ortiz;V. Vitelli;Adam E. Cohen
通讯作者：
Hillel Ori;Marc Duque;Rebecca Frank Hayward;Colin Scheibner;He Tian;Gloria Ortiz;V. Vitelli;Adam E. Cohen

Preparation of metrological states in dipolar-interacting spin systems

DOI：
10.1038/s41534-022-00667-4
发表时间：
2022-03
期刊：
npj Quantum Information
影响因子：
7.6
作者：
Tian-Xing Zheng;Anran Li;Jude Rosen;Sisi Zhou;M. Koppenhöfer;Ziqi Ma;F. Chong;A. Clerk
通讯作者：
Tian-Xing Zheng;Anran Li;Jude Rosen;Sisi Zhou;M. Koppenhöfer;Ziqi Ma;F. Chong;A. Clerk

Heteroatom substitution for the development of near-IR lumiphores