GCR: Meta-Optical Angioscopes for Image-Guided Therapies in Previously Inaccessible Locations

GCR：元光学血管镜，用于在以前无法到达的位置进行图像引导治疗

• 批准号: 2120774
• 负责人: Arka Majumdar
• 金额: $ 360万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2026-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2120774&HistoricalAwards=false
• 关键词: GCR; Meta; Optical; Angioscopes; Image

Angioscopes are ultrathin and flexible forward-viewing optical imaging devices that guide clinical procedures in the cardiovascular system. Cardiovascular disease, led by heart attack and stroke, are the leading cause of death in the US and globally. Due to basic limitations of conventional optics, these angioscopes are currently made with a bundle of over a thousand glass optical fibers, a 50-year-old technology that provides resolution that is too low and a stiffness that is too high for important potential applications. To reach clinically significant targets in the brain and heart, the angioscope needs to be more flexible and the rigid tip length must be reduced to only a few times the width of a human hair. Such an incredibly agile angioscope in the hands of a neurosurgeon could snake its way deep into the brain to remove blood clots, which can help a stroke patient. Further, a cardiologist could use this device to pass vessel-clogging plaque deposits and accurately apply a range of therapies in coronary arteries in response to heart attacks. The potential to reduce morbidity and mortality from stroke and heart attacks could benefit many individuals. This research project at the interface between nanophotonics and bioengineering aims to develop the technology that could enable such ultra-miniature agile angioscopes by using emerging optical hardware and artificial intelligence-enabled software image reconstruction. The project brings together scientists and engineers from academia and startup companies with medical professionals to solve this high-impact problem. Ultrathin and flexible forward-viewing endoscopes, also known as angioscopes, are of critical importance for treating many cardiovascular diseases, including stroke and heart attacks, both of which are among the leading causes of death in the United States. Current medical instruments based on traditional refractive optics are too bulky to be used deep in the brain and in diseased coronary arteries. To reach locations of stroke in the brain, the rigid tip length in an angioscope must be reduced to sub-millimeter length scale. Emerging nanophotonics and metamaterial technology have the potential to achieve such clinically significant miniaturization. Meta-optics provide many degrees of freedom to design completely new types of optical elements. Multi-scale electromagnetic simulation coupled with optimization techniques have already enabled design of a meta-optic combining functionalities of multiple optical elements. In conjunction with a computational backend, meta-optics that also capture aberration-free images in full color should be possible. Combining computational inverse methods based on machine learning, semiconductor nanomanufacturing, and techniques from medical instrumentation, including advanced saline flushing, this project aims to create a micro-imaging system with 250-micron aperture and 100-micron rigid tip thickness, which will capture full-color images in a 100-degree field of view with cellular resolution. Along with academic researchers from basic science and engineering disciplines, this project includes partners associated with startups commercializing meta-optics and endoscopes as well as minimally invasive, interventional surgeons specializing in cardiovascular diseases.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

血管镜是超薄且灵活的前视光学成像设备，可指导心血管系统的临床手术。以心脏病和中风为首的心血管疾病是美国和全球的主要原因。由于传统光学器件的基本限制，这些血管镜目前由一束超过 1000 根玻璃光纤制成，这是一项已有 50 年历史的技术，其分辨率过低，刚度过高，无法满足重要的潜在应用需求。为了到达大脑和心脏中具有临床意义的目标，血管镜需要更加灵活，并且刚性尖端长度必须减少到人类头发宽度的几倍。神经外科医生手中如此灵活的血管镜可以蜿蜒深入大脑以清除血凝块，这可以帮助中风患者。此外，心脏病专家可以使用该设备清除血管堵塞的斑块沉积物，并准确地在冠状动脉中应用一系列疗法来应对心脏病发作。降低中风和心脏病发病率和死亡率的潜力可能会使许多人受益。该研究项目位于纳米光子学和生物工程之间，旨在开发一种技术，通过使用新兴的光学硬件和人工智能软件图像重建来实现这种超小型敏捷血管镜。该项目汇集了来自学术界和初创公司的科学家和工程师以及医疗专业人员，以解决这一影响深远的问题。超薄灵活的前视内窥镜（也称为血管镜）对于治疗许多心血管疾病至关重要，包括中风和心脏病，这两种疾病都是美国的主要原因之一。目前基于传统折射光学器件的医疗仪器体积太大，无法在大脑深处和患病的冠状动脉中使用。为了到达大脑中的中风部位，血管镜的刚性尖端长度必须减少到亚毫米长度。新兴的纳米光子学和超材料技术有潜力实现这种具有临床意义的小型化。元光学为设计全新类型的光学元件提供了许多自由度。多尺度电磁仿真与优化技术相结合已经能够设计出结合多个光学元件功能的元光学。与计算后端相结合，元光学也可以捕获全彩的无像差图像。该项目结合基于机器学习、半导体纳米制造和医疗仪器技术（包括先进的盐水冲洗）的计算逆方法，旨在创建一个具有 250 微米孔径和 100 微米刚性尖端厚度的微成像系统，该系统将捕获完整的图像。 - 100 度视野中具有细胞分辨率的彩色图像。该项目除来自基础科学和工程学科的学术研究人员外，还包括与元光学和内窥镜商业化的初创公司以及专门从事心血管疾病的微创介入外科医生相关的合作伙伴。该奖项反映了 NSF 的法定使命，并被认为值得支持通过使用基金会的智力优点和更广泛的影响审查标准进行评估。

项目成果

Dual Band Computational Infrared Spectroscopy via Large Aperture Meta-Optics

• DOI: 10.1021/acsphotonics.2c01017
• 发表时间: 2022-09-19
• 期刊: ACS PHOTONICS
• 影响因子: 7
• 作者: Froch, Johannes E.;Colburn, Shane;Majumdar, Arka
• 通讯作者: Majumdar, Arka

Partially Coherent Double-Phase Holography in Visible Wavelength Using Meta-Optics

• DOI: 10.1021/acsphotonics.2c02016
• 发表时间: 2023-03
• 期刊: ACS Photonics
• 影响因子: 7
• 作者: Saswata Mukherjee;Quentin A. A. Tanguy-Quentin-A.-A.-Tanguy-15704552;Johannes E. Fröch;A. Shanker;K. Böhringer;S. Brunton;A. Majumdar

Software-defined meta-optics

• DOI: 10.1063/5.0164387
• 发表时间: 2023-10
• 期刊: Applied Physics Letters
• 影响因子: 4
• 作者: Romil Audhkhasi;Johannes E. Fröch;A. Zhan;S. Colburn;A. Majumdar

Large area optimization of meta-lens via data-free machine learning

• DOI: 10.1038/s44172-023-00107-x
• 发表时间: 2022-12
• 期刊: Communications Engineering
• 作者: M. Zhelyeznyakov;Johannes E. Fröch;A. Wirth-Singh;Jae-Eok Noh;J. Rho;Steve Brunton;A. Majumdar

Inverse‐Designed Meta‐Optics with Spectral‐Spatial Engineered Response to Mimic Color Perception

• DOI: 10.1002/adom.202200734
• 发表时间: 2022-04
• 期刊: Advanced Optical Materials
• 影响因子: 9
• 作者: Christopher Munley;Wen-Hai Ma;Johannes E. Fröch;Quentin A. A. Tanguy-Quentin-A.-A.-Tanguy-15704552;E. Bayati;K. Böhringer;Zin Lin;R. Pestourie;Steven G. Johnson;A. Majumdar