A multi-scale approach to predicting infectious multi-host disease spread in marine benthic communities

预测海洋底栖群落传染性多宿主疾病传播的多尺度方法

• 批准号: 2109622
• 负责人: Marilyn Brandt
• 金额: $ 249.99万
• 依托单位: University of The Virgin Islands
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2109622&HistoricalAwards=false
• 关键词: multi; scale; approach; predicting; infectious

Marine diseases have devastating impacts on ocean ecosystems and this work will directly examine the framework for understanding disease transmission in the ocean. A team of ecologists, ocean connectivity and disease modelers, microbiologists, and coral immunologists (from the University of Virgin Islands (UVI), Louisiana State University (LSU), Rice University, University of Texas-Arlington and the Woods Hole Oceanographic Institution) will develop a model that predicts transmission of a devastating Caribbean coral disease that has the potential to impact the economic value of coral reefs, including those located in the U.S. This project will support multidisciplinary field and laboratory research experiences of graduate students at multiple minority-serving institutions, and will provide undergraduate students with hands-on training in modeling, ecological and molecular analysis techniques. UVI and LSU are in EPSCoR jurisdictions and have diverse student bodies, including numerous under-represented minority (URM) students. The research team will collaboratively provide URM students with research experiences in STEM fields. Project findings will be broadly communicated through virtual public programming, and through the Virgin Islands Coral Disease Advisory Committee with updates on the vicoraldisease.org website. A coral disease response workshop for the U.S. Virgin Islands will also be held, in which project results will be presented and used to support disease response planning.Over the last four decades, marine diseases have decimated ecosystem engineers in marine coastal ecosystems, including the rocky intertidal, seagrasses and coral reefs. The pathogens driving these diseases have frequently been challenging to isolate, characterize and confirm, in part because they affect multiple host species and can spread by ocean currents, as well as through individual contact. Here, we propose a multi-scale epidemic model for studying marine disease that addresses both within-host and within-patch disease dynamics, and explicitly acknowledges the dispersal of pathogens between populations. Our interdisciplinary research team of ecologists, connectivity and disease modelers, microbiologists, and coral immunologists will integrate the largest set of predictors of marine disease spread to date: individual host species traits that allow for disease resistance or susceptibility, local transmission within communities that may have unique community structure, and hydrodynamic connectivity among susceptible communities. Modeling will be supported with rich data sets of within- and among-patch population characteristics and disease dynamics as well as molecular data on species-level disease responses. This project will advance knowledge of infectious diseases by integrating multidimensional scales and differential host susceptibilities into existing epidemiological models. This model will particularly advance the framework for studying marine diseases and has the potential to elucidate the transmission properties of a devastating Caribbean coral disease (stony coral tissue loss disease) that fits the most confounding and notorious hallmarks of marine diseases: infection of multiple hosts by an elusive pathogen.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

海洋疾病对海洋生态系统产生了破坏性的影响，这项工作将直接研究了解海洋中疾病传播的框架。一个生态学家，海洋连通性和疾病建模者，微生物学家和珊瑚免疫学家（来自维尔京群岛大学（UVI），路易斯安那州立大学（LSU），赖斯大学，莱斯大学，德克萨斯州 - 阿灵顿大学和伍兹孔海洋学机构）的团队将开发出一种迫切的加勒比殖民疾病的措施，这些模型将在迫害的情况下产生影响，从而预测这种措施的经济性，从而影响了这种危险的加勒比殖民疾病的经济性，该措施旨在实现经济疾病的影响。项目将支持多个少数派服务机构的研究生的多学科领域和实验室研究经验，并将为本科生提供在建模，生态和分子分析技术方面的动手培训。 UVI和LSU处于EPSCOR司法管辖区，并拥有多样化的学生团体，其中包括众多代表性不足的少数民族（URM）学生。研究团队将协作为URM学生提供STEM领域的研究经验。项目发现将通过虚拟公共节目和通过Virgin Islands Coral疾病咨询委员会进行广泛传达，并在vicoraldisease.org网站上进行更新。还将举办一个为维尔京群岛举行的珊瑚疾病反应研讨会，其中将提出项目结果并用来支持疾病反应计划。在过去的四十年中，海洋疾病已经破坏了海洋沿海生态系统中的生态系统工程师，包括岩石潮间带，海草和珊瑚礁。驱动这些疾病的病原体经常具有挑战性地孤立，表征和确认，部分原因是它们会影响多种宿主物种，并且可以通过洋流传播以及通过个人接触来传播。在这里，我们提出了一个多尺度流行模型，用于研究海洋疾病，以解决宿主内部和内部疾病动力学，并明确承认种群之间病原体的分散。我们的生态学家，连通性和疾病建模者，微生物学家和珊瑚免疫学家的跨学科研究团队将整合迄今为止海洋疾病的最大预测因素：迄今为止的个别宿主物种特征，允许疾病抵抗性或易感性，允许在社区内具有独特社区结构以及具有独特社区结构的局部传播，以及具有独特的社区结构和流体动态连接性。建模将得到丰富的数据集和斑点种群特征和疾病动力学以及物种水平疾病反应的分子数据的支持。该项目将通过将多维量表和差异宿主敏感性整合到现有的流行病学模型中来提高传染病的知识。该模型将特别推进研究海洋疾病的框架，并有可能阐明令人震惊的加勒比珊瑚珊瑚疾病的传播特性（Stony珊瑚组织损失疾病），该疾病（Stony Coral组织损失疾病）符合最令人困惑和最臭名昭著的海洋疾病标志：通过难以置信的Pathogen奖，这是通过nsf的宣传来支持多个宿主的感染。优点和更广泛的影响审查标准。

项目成果

Coral disease outbreak at the remote Flower Garden Banks, Gulf of Mexico

墨西哥湾偏远花园岸爆发珊瑚病

• DOI: 10.3389/fmars.2023.1111749
• 发表时间: 2023
• 期刊: Frontiers in Marine Science
• 影响因子: 3.7
• 作者: Johnston, Michelle A.;Studivan, Michael S.;Enochs, Ian C.;Correa, Adrienne M.;Besemer, Nicole;Eckert, Ryan J.;Edwards, Kimberly;Hannum, Ryan;Hu, Xinping;Nuttall, Marissa
• 通讯作者: Nuttall, Marissa

Rates of Future Climate Change in the Gulf of Mexico and the Caribbean Sea: Implications for Coral Reef Ecosystems

• DOI: 10.1029/2022jg006999
• 发表时间: 2022-08
• 期刊: Journal of Geophysical Research: Biogeosciences
• 作者: A. Lawman;S. Dee;K. Delong;A. Correa

Thank you for biting: dispersal of beneficial microbiota through 'antagonistic' interactions

• DOI: 10.1016/j.tim.2022.03.006
• 发表时间: 2022-09-12
• 期刊: TRENDS IN MICROBIOLOGY
• 影响因子: 15.9
• 作者: Grupstra, C. G. B.;Lemoine, N. P.;Correa, A. M. S.
• 通讯作者: Correa, A. M. S.