SBIR Phase I: Integrated Manufacturing of Artificial Valves for Medical Use

SBIR第一期：医用人工瓣膜集成制造

• 批准号: 2051102
• 负责人: JANET Galtes
• 金额: $ 25.56万
• 依托单位: VENARUM MEDICAL, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2051102&HistoricalAwards=false
• 关键词: SBIR; Phase; Integrated; Manufacturing; Artificial

The broader impact of this Small Business Innovation Research (SBIR) Phase I project is to improve clinical outcomes for patients needing valves for vascular (veins) or urinary systems. It is difficult to make artificial versions of the fluid control elements, such as valves, that are biocompatible and withstand the physical forces associated with their function, as well as the changing environment associated with aging. The proposed project advances a system to make artificial sutureless devices.The proposed project will optimize the materials and variables of manufacturing a polymer valve integrated with durable polymer encapsulation of a structural Nitinol frame. This Nitinol-polymer structure must withstand long-term challenging in vivo conditions while maintaining a physical interface that does not experience premature delamination and loss of device functionality. Polyurethane materials have excellent mechanical properties for rigorous applications and history of use in implants. This project explores the phase space of relevant parameters for manufacturing and deployment of these valves at scale.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I期项目的更广泛影响是改善需要血管（静脉）或尿液系统瓣膜的患者的临床结果。 很难制作具有生物相容性并承受与其功能相关的物理力以及与衰老相关的环境变化的物理力的人工版本（例如阀）。拟议的项目正在推进一个制造人造无用设备的系统。拟议的项目将优化制造与结构性奈蒂醇框架的耐用聚合物封装的聚合物阀的材料和变量。这种Nitinol-聚合物结构必须承受体内挑战性的长期挑战，同时保持没有过早分层和设备功能损失的物理界面。聚氨酯材料具有极好的机械性能，可用于植入物中的严格应用和使用史。该项目探讨了按大规模制造和部署这些阀的相关参数的相空间。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响评估标准通过评估来获得支持的。