CAREER: Combining Engineering, Biomechanics, and Genetic Analysis to Enable the Design of Structurally Superior Grain Crops

职业:结合工程、生物力学和遗传分析,设计结构优越的谷物作物

基本信息

  • 批准号:
    2046669
  • 负责人:
  • 金额:
    $ 62.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-01 至 2026-03-31
  • 项目状态:
    未结题

项目摘要

This Faculty Early Career Development (CAREER) award will combine modern tools from the fields of biomechanics, structural engineering, and genetics to provide new understanding of the factors that contribute to stalk strength of grain crops. The long-term goal of this work is to intentionally optimize (i.e., design) the architecture of grain crops. These new varieties will have the potential for exceptionally high yield and biofuel production. Maize (corn) is the largest crop in the US and will be the primary subject of this research. Tools and techniques from structural engineering will be used. These include structural tests, the use of new devices for measuring stalk strength in the field, and focused measurements of the geometry and mechanical properties of maize stalk tissues. Genetic techniques will include the use of breeding experiments to generate a population of maize stalks having a broad range of structural and genetic diversity. This population will be analyzed to determine the influence of specific genes on maize stalk strength and other key characteristics. Finally, structural and genetic information will be combined to create powerful new computational models of maize stalk strength. These new models will allow optimization studies. The results will suggest ways for achieving grain crops that are high-yielding while also being suitable for second-generation biofuel production. To carry out this work, students will receive training and extensive mentoring and professional development alongside their scientific training.The specific aims of this research are: (1) generate genetic and structural diversity through selective breeding and transgenic experiments; (2) perform biomechanical measurements of physical specimens; and (3) use computational modeling to investigate optimal stalk archetypes. Specimen diversity will be created using test-cross and inter-cross breeding experiments. Biomechanical measurements (bending tests, mechanical tissue tests, and morphological measurements) will be performed on these specimens as well as on transgenic varieties previously generated. This information will be used to quantify the influence of specific candidate genes identified in previous studies. Finally, a parameterized computational modeling platform will be created to allow sensitivity and optimization analyses. This research is expected to provide valuable new insights on the influences of structural factors and candidate genes on the structural resilience of crops, thus enabling new breeding approaches that seek to follow the optimization results provided by this study. This work is co-funded by the Plant, Fungal and Microbial Developmental Mechanisms program in the Directorate for Biological Sciences, Division of Integrative Organismal Systems.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该教师早期职业发展(职业)奖将结合现代工具,从生物力学,结构工程和遗传学领域,以提供对有助于谷物作物茎强度的因素的新了解。这项工作的长期目标是故意优化(即设计)谷物作物的结构。这些新品种将具有异常高产和生物燃料生产的潜力。玉米(玉米)是美国最大的农作物,将是这项研究的主要主题。将使用结构工程的工具和技术。 这些包括结构性测试,使用新设备来测量田间的茎强度,以及玉米茎组织的几何形状和机械性能的重点测量。遗传技术将包括使用育种实验来产生具有广泛结构和遗传多样性的玉米茎。将分析该人群,以确定特定基因对玉米茎强度和其他关键特征的影响。最后,将结合结构和遗传信息,以创建强大的玉米茎强度的新计算模型。这些新模型将允许优化研究。 结果将为实现高收益而同时适合第二代生物燃料生产的谷物作物提出建议。 为了进行这项工作,学生将在科学培训的同时获得培训和广泛的指导和专业发展。这项研究的具体目的是:(1)通过选择性育种和转基因实验来产生遗传和结构多样性; (2)对物理标本进行生物力学测量; (3)使用计算建模来研究最佳的茎原型。标本多样性将使用测试跨和交叉育种实验创建。将对这些标本以及先前生成的转基因品种进行生物力学测量(弯曲测试,机械组织测试和形态测量)。该信息将用于量化先前研究中鉴定的特定候选基因的影响。最后,将创建一个参数化的计算建模平台,以允许灵敏度和优化分析。预计这项研究将对结构因素和候选基因对农作物结构弹性的影响提供宝贵的新见解,从而实现新的育种方法,以遵循本研究提供的优化结果。 这项工作由工厂,真菌和微生物发育机制计划在生物科学局,综合有机系统的部门中共同资助。该奖项反映了NSF的法定任务,并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准来通过评估来获得支持的。

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Maize lodging resistance: Stalk architecture is a stronger predictor of stalk bending strength than chemical composition
  • DOI:
    10.1016/j.biosystemseng.2022.04.010
  • 发表时间:
    2022-05-17
  • 期刊:
  • 影响因子:
    5.1
  • 作者:
    Robertson, Daniel J.;Brenton, Zachary W.;Cook, Douglas D.
  • 通讯作者:
    Cook, Douglas D.
A parameterised model of maize stem cross-sectional morphology
  • DOI:
    10.1016/j.biosystemseng.2022.03.010
  • 发表时间:
    2022-04-26
  • 期刊:
  • 影响因子:
    5.1
  • 作者:
    Ottesen, Michael A.;Larson, Ryan A.;Cook, Douglas D.
  • 通讯作者:
    Cook, Douglas D.
Cell wall mechanics: Some new twists
细胞壁力学:一些新的变化
  • DOI:
    10.1016/j.bpj.2022.02.017
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Weizbauer, Renate A.;Cook, Douglas D.
  • 通讯作者:
    Cook, Douglas D.
Development and stochastic validation of a parameterized model of maize stalk flexure and buckling
  • DOI:
    10.1093/insilicoplants/diad010
  • 发表时间:
    2023-07-01
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    Ottesen,Michael;Carter,Joseph;Cook,Douglas D.
  • 通讯作者:
    Cook,Douglas D.
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Douglas Cook其他文献

Contribution of PMd and A5 to feedback responses to mechanical disturbances of the limb in non-human primates
  • DOI:
    10.1016/j.ibror.2019.07.526
  • 发表时间:
    2019-09-01
  • 期刊:
  • 影响因子:
  • 作者:
    Tomohiko Takei;Stephen Lomber;Douglas Cook;Stephen Scott
  • 通讯作者:
    Stephen Scott

Douglas Cook的其他文献

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{{ truncateString('Douglas Cook', 18)}}的其他基金

GOALI: Addressing Corn Stalk Breakage: An Engineering Approach to an Important Agronomical Problem
目标:解决玉米秸秆破损问题:解决重要农艺问题的工程方法
  • 批准号:
    1400973
  • 财政年份:
    2014
  • 资助金额:
    $ 62.42万
  • 项目类别:
    Continuing Grant
Deducing the Genomic Footprint and Functional Impact of Chickpea Domestication on Nitrogen Fixation
推断鹰嘴豆驯化对固氮的基因组足迹和功能影响
  • 批准号:
    1339346
  • 财政年份:
    2013
  • 资助金额:
    $ 62.42万
  • 项目类别:
    Standard Grant
Elucidating the symbiotic signaling pathway in legumes
阐明豆类中的共生信号通路
  • 批准号:
    1122261
  • 财政年份:
    2012
  • 资助金额:
    $ 62.42万
  • 项目类别:
    Standard Grant
Meeting: 6th International Conference on Legume Genetics and Genomics (ICLGG) to be held October 2-7 2012 in Hyderabad, India
会议:第六届豆类遗传学和基因组学国际会议 (ICLGG) 将于 2012 年 10 月 2-7 日在印度海得拉巴举行
  • 批准号:
    1239731
  • 财政年份:
    2012
  • 资助金额:
    $ 62.42万
  • 项目类别:
    Standard Grant
BREAD: Overcoming the Domestication Bottleneck for Symbiotic Nitrogen Fixation in Legumes
面包:克服豆类共生固氮的驯化瓶颈
  • 批准号:
    0965531
  • 财政年份:
    2010
  • 资助金额:
    $ 62.42万
  • 项目类别:
    Continuing Grant
Comparative Genomics of Legume Disease Resistance Gene Homologs
豆类抗病基因同源物的比较基因组学
  • 批准号:
    0605251
  • 财政年份:
    2006
  • 资助金额:
    $ 62.42万
  • 项目类别:
    Continuing Grant
Model Legume Congress Proposal to be held June 5-9, 2005 at the Asilomar Conference Center, Pacific Gove, California.
示范豆类大会提案将于 2005 年 6 月 5 日至 9 日在加利福尼亚州太平洋戈夫的阿西洛玛会议中心举行。
  • 批准号:
    0527038
  • 财政年份:
    2005
  • 资助金额:
    $ 62.42万
  • 项目类别:
    Standard Grant
NSF East Asia Summer Institutes for US Graduate Students
NSF 东亚美国研究生暑期学院
  • 批准号:
    0513249
  • 财政年份:
    2005
  • 资助金额:
    $ 62.42万
  • 项目类别:
    Fellowship
Towards the Complete Gene Inventory and Function of the Medicago Truncatula Genome
蒺藜苜蓿基因组的完整基因库和功能
  • 批准号:
    0110206
  • 财政年份:
    2001
  • 资助金额:
    $ 62.42万
  • 项目类别:
    Continuing Grant
Plant Genetic Control of Nodule Number in Medicago truncatula
蒺藜苜蓿根瘤数的植物遗传控制
  • 批准号:
    0196196
  • 财政年份:
    2000
  • 资助金额:
    $ 62.42万
  • 项目类别:
    Standard Grant

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