MRI: Acquisition of an X-band Continuous-wave Electron Paramagnetic Resonance (EPR) Spectrometer

MRI：采集 X 波段连续波电子顺磁共振 (EPR) 能谱仪

• 批准号: 2019066
• 负责人: Joshua Figueroa
• 金额: $ 37.67万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2019066&HistoricalAwards=false
• 关键词: MRI; Acquisition; band; Continuous; wave

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of California-San Diego is acquiring an X-band continuous-wave electron paramagnetic resonance (CW-EPR) spectrometer to support Professor Joshua Figueroa and colleague, Galia Debelouchina. In general, an EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid-state materials. It is also used to obtain information about the lifetimes of free radicals (short-lived, highly reactive species) involved in valuable chemical transformations of biological interest. The acquisition strengthens the research infrastructure at this Hispanic-Serving Institution as well as in the region. The instrument broadens participation by involving diverse groups of students in research and research training using this modern technique. It also provides training opportunities to many undergraduate and graduate students as well as postdoctoral fellows at this institution as well as several neighboring institutions such as San Diego State University and the University of San Diego. The award of the EPR spectrometer is aimed at enhancing research and education at all levels. The instrument acquisition impacts studies characterizing coordinatively-unsaturated transition metal centers. The instrumentation is used for research on the development of new methodologies to study the structure of biological macromolecules in cells and the catalytic mechanism of nitrogenase. In addition, the EPR provides information to further explore the role of paramagnetic species in natural and synthetic melanin polymers and the generation of stable radical-containing species and their reactivity towards small molecules. The EPR spectrometer is also used to inform studies of the mechanism of electron-transfer reactions. It is utilized in designing transition-metal doped metal oxide materials with precisely tunable electronic and spin-qubit array properties.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目支持。加州大学圣地亚哥分校正在购买一台 X 波段连续波电子顺磁共振 (CW-EPR) 能谱仪，以支持 Joshua Figueroa 教授和同事 Galia Debelouchina。一般来说，EPR 光谱仪可提供分子和固态材料的几何和电子结构的详细信息。它还用于获取有关参与具有生物学价值的化学转化的自由基（寿命短、高反应性物质）寿命的信息。此次收购加强了该拉美裔服务机构以及该地区的研究基础设施。该工具通过使用这种现代技术让不同的学生群体参与研究和研究培训来扩大参与范围。它还为该机构以及圣地亚哥州立大学和圣地亚哥大学等几所邻近机构的许多本科生和研究生以及博士后提供培训机会。 EPR 光谱仪的获奖旨在加强各级研究和教育。仪器的获取影响了表征配位不饱和过渡金属中心的研究。该仪器用于开发新方法学的研究，以研究细胞内生物大分子的结构和固氮酶的催化机制。此外，EPR 还提供了进一步探索顺磁性物质在天然和合成黑色素聚合物中的作用以及稳定的含自由基物质的生成及其对小分子的反应性的信息。 EPR 光谱仪还用于为电子转移反应机制的研究提供信息。 它用于设计具有精确可调电子和自旋量子位阵列特性的过渡金属掺杂金属氧化物材料。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

A Complete Triad of Zero‐Valent 17‐Electron Monoradicals of Group 7 Elements Stabilized by m ‐Terphenyl Isocyanides

间·三联苯异氰化物稳定的第 7 族元素的完整零价 17 价电子单价基团

• DOI: 10.1002/anie.202300254
• 发表时间: 2023-04
• 期刊: Angewandte Chemie International Edition
• 作者: Salsi, Federico;Wang, Shuai;Teutloff, Christian;Busse, Marvin;Neville, Michael L.;Hagenbach, Adelheid;Bittl, Robert;Figueroa, Joshua S.;Abram, Ulrich
• 通讯作者: Abram, Ulrich

DNP-enhanced solid-state NMR spectroscopy of chromatin polymers

染色质聚合物的 DNP 增强固态核磁共振波谱

• DOI: 10.1016/j.jmro.2022.100057
• 发表时间: 2022-06
• 期刊: Journal of Magnetic Resonance Open
• 作者: Elathram, Nesreen;Ackermann, Bryce E.;Debelouchina, Galia T.
• 通讯作者: Debelouchina, Galia T.

Overcoming universal restrictions on metal selectivity by protein design

通过蛋白质设计克服金属选择性的普遍限制

• DOI: 10.1038/s41586-022-04469-8
• 发表时间: 2022-03
• 期刊: Nature
• 影响因子: 64.8
• 作者: Choi, Tae Su;Tezcan, F. Akif
• 通讯作者: Tezcan, F. Akif

Dynamic Nuclear Polarization Illuminates Key Protein–Lipid Interactions in the Native Bacterial Cell Envelope

动态核极化揭示了天然细菌细胞包膜中关键蛋白质与脂质的相互作用

• DOI: 10.1021/acs.biochem.3c00262
• 发表时间: 2023-08
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: Kent, James E.;Ackermann, Bryce E.;Debelouchina, Galia T.;Marassi, Francesca M.
• 通讯作者: Marassi, Francesca M.

A Comparative Study of Nitroxide‐Based Biradicals for Dynamic Nuclear Polarization in Cellular Environments

细胞环境中基于氮氧化物的双自由基动态核极化的比较研究

• DOI: 10.1002/cbic.202200577
• 发表时间: 2022-12-16
• 期刊: ChemBioChem
• 影响因子: 3.2
• 作者: Ackermann, Bryce E.;Lim, Byung Joon;Elathram, Nesreen;Narayanan, Sirish;Debelouchina, Galia T.
• 通讯作者: Debelouchina, Galia T.