I-Corps: Accelerating discovery research into neural-stem-cell-driven tissue regrowth through modeling and simulation

I-Corps：通过建模和模拟加速神经干细胞驱动的组织再生的发现研究

• 批准号: 2040036
• 负责人: Gunther Zupanc
• 金额: $ 5万
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2040036&HistoricalAwards=false
• 关键词: Corps; Accelerating; discovery; research; into

The broader impact/commercial potential of this I-Corps project is to define the requirements of modeling and simulation platforms for drug development and/or intervention strategies used in tissue repair. These strategies may be more predictive and efficient than currently available through application of experimental approaches. Ultimately, the goal for this tool is to make possible regeneration of neural tissue lost to traumatic brain injury, spinal cord injury, or stroke. Reaching this goal may transform the lives of millions of patients and their families while also substantially reducing the financial burdens to society. The translation will offer the platform as a service tailored to the needs of scientists in preclinical (discovery) research departments of pharmaceutical and biotech companies. By providing domain expertise in the modeling of stem-cell-driven tissue regeneration, clients will be enabled to narrow down the range of potentially effective compounds or intervention strategies to those treatments with the highest probability to succeed. This strategy could accelerate the discovery process, while reducing the costs and time involved in research and development.This I-Corps project is based on advancing the development of mathematical and computational models for a drug discovery platform aimed at neural tissue repair. Informed by comprehensive cell-biological data sets, these models simulate the dynamics of stem cell-driven tissue growth during the normal development of the brain and spinal cord. In addition, the models simulate the regenerative response of the central nervous system after traumatic brain injury, spinal cord injury, and stroke. In recent years, promising therapeutic strategies have been developed to promote tissue regrowth, including activation of adult neural stem cells intrinsic to the patient’s central nervous system, and the transplantation of extrinsic neural stem cells to the site of cell loss. The selection and design of tests for development of such intervention strategies is currently based on “trial and error.” However, due to the complexity of biological factors and processes involved in successful structural regeneration and functional recovery, this approach consumes considerable resources and curtails progress in the discovery of effective treatment strategies. This process may be streamlined by employing modeling and simulations. Such a strategy may help scientists to select the most meaningful experiments, thereby reducing time and costs associated with lab work, while at the same time raising the quality of the research.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在组织修复中使用的药物NT和/或策略的模型和/或策略的模拟和/或仿真的更广泛的影响/商业化。受伤，达到这一目标，可能会改变数百万患者及其家人的患者的生活，同时减少了对社会的财务负担。 （发现）药物和生物技术公司的ETS。研究和开发中涉及的成本和时间基于用于神经组织修复的药物发现平台的数学和模型的开发。大脑和脊髓的正常发育。目前，患者的中央神经系统设计用于开发搜索干预策略的测试是基于“反复试验”。这样的策略可以帮助科学家选择有意义的实验。该奖项反映了NSF的反应，并使用基金会的知识和更广泛的影响标准通过评估值得支持。