CAS: RUI: Click Synthesis and Structure-Property-Function Relationships of Amphiphilic Ionic Liquids

CAS：RUI：两亲性离子液体的点击合成及其结构-性能-功能关系

• 批准号: 1952846
• 负责人: Arsalan Mirjafari
• 金额: $ 24.98万
• 依托单位: Florida Gulf Coast University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1952846&HistoricalAwards=false
• 关键词: CAS; RUI; Click; Synthesis; Structure

In this RUI project, funded by the Chemical Structure, Dynamics and Mechanisms B Program of the Chemistry Division, Professor Arsalan Mirjafari and his students of the Department of Chemistry & Physics at the Florida Gulf Coast University are developing new type of organic materials called ionic liquids. Ionic liquids are liquid salts comprised entirely of ions. The search for new ionic liquids is driven in part by efforts to address unmet needs in medicine and energy. Salts of this kind can be utilized as alternatives for more conventional organic solvents in various applications, including electronic materials, new generation of rechargeable batteries, and gene delivery. The project is designed to advance the scientific enterprise in tandem with educating and training undergraduate students to become the next generation of chemists. The project brings together elements of chemical synthesis, computer modeling as well as advanced materials development and characterizations, providing undergraduate students with opportunities to experience faculty-mentored research. Since Florida Gulf Coast University has a large underrepresented minority population in Science, Technology, Engineering, and Math (STEM) fields, the project provides important opportunities to engage in the professional training of individuals from these communities. Outreach activities involving local middle and high schools is part of the funded project as well. Fundamental to the field of ionic liquids is the understanding that structure begets function. In this project, Professor Mirjafari seeks the development of functional ionic liquids that simultaneously have improved fluidity and amphiphilic character – a combination of attributes that, while frequently antithetical, is very desirable in many applications. Click reactions are utilized to incorporate a diverse array of functional groups into the thioamide-based heterocyclic cations structures. The research involves efforts to understand the relationships between the chemical structure and physicochemical properties and the development of ionic liquids for specific functions including aliphatic/aromatic separation, liquid crystals, fluoride-ion electrochemistry, and gene transfer. New strategies are being pursued to improve the chemical stability and toxicity profiles of ionic liquids.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这个由化学结构，动力学和机制B计划资助的RUI项目中，佛罗里达墨西哥湾沿岸大学化学与物理系的Arsalan Mirjafari教授及其学生正在开发新型的有机材料，称为离子液体。离子液体是完全包含离子的液体。寻找新的离子液体的搜索部分是由于解决医学和能量的未满足需求而驱动的。这种盐可以用作各种应用中更常规的有机溶液的替代方法，包括电子材料，新一代可充电电池和基因输送。该项目旨在促进科学企业与教育和培训本科生一起成为下一代化学家。该项目汇集了化学合成，计算机建模以及高级材料开发和角色的元素，从而为本科生提供了体验教师的研究的机会。由于佛罗里达墨西哥湾海岸大学在科学，技术，工程和数学（STEM）领域的代表人数不足，因此该项目提供了重要的机会，可以从事这些社区个人的专业培训。涉及当地中学和高中的外展活动也是资助项目的一部分。离子液体领域的基础是理解结构将成为功能。在该项目中，Mirjafari教授寻求功能性离子液体的发展，这些液体仅提高了流动性和两亲性 - 属性的结合，尽管经常相反，但在许多应用中都是非常需要的。点击反应用于将功能组的潜水阵列纳入基于硫酰胺的杂环阳离子结构中。该研究涉及了解化学结构与物理特性之间的关系以及离子液体的发展，以用于特定功能，包括脂肪族/芳香族分离，液晶，氟化物离子电化学和基因转移。正在采取新的策略来改善离子液体的化学稳定性和毒性概况。该奖项反映了NSF的法定任务，并认为使用基金会的知识分子优点和更广泛的影响评估标准，认为值得通过评估来获得支持。

项目成果

Molecular design principles of ionic liquids with a sulfonyl fluoride moiety

• DOI: 10.1039/d0nj05603k
• 发表时间: 2021-02
• 期刊: New Journal of Chemistry
• 影响因子: 3.3
• 作者: David J. Siegel;Grace I Anderson;Noah Cyr;D. Lambrecht;M. Zeller;Patrick C. Hillesheim;A. Mirjafari

Covalently linked hydrogen bond donors: The other side of molecular frustration in deep eutectic solvents

• DOI: 10.1063/5.0058165
• 发表时间: 2021-08-28
• 期刊: JOURNAL OF CHEMICAL PHYSICS
• 影响因子: 4.4
• 作者: Recker, Elizabeth A.;Hardy, David;Wagle, Durgesh V.
• 通讯作者: Wagle, Durgesh V.

Cyclopropane as an Unsaturation “Effect Isostere”: Lowering the Melting Points in Lipid-like Ionic Liquids

环丙烷作为不饱和度“等排效应”：降低类脂离子液体的熔点

• DOI: 10.1021/acs.jpcb.2c07872
• 发表时间: 2023
• 期刊: The Journal of Physical Chemistry B
• 作者: O’Brien, Richard A.;Hillesheim, Patrick C.;Soltani, Mohammad;Badilla-Nunez, Kelly J.;Siu, Ben;Musozoda, Muhammadiqboli;West, Kevin N.;Davis, James H.;Mirjafari, Arsalan
• 通讯作者: Mirjafari, Arsalan