Multiphase-Separation and Control of Serially Produced Reactive Oxygen

连续生产活性氧的多相分离与控制

• 批准号: 1856765
• 负责人: Alexander Greer
• 金额: $ 44万
• 依托单位: CUNY Brooklyn College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1856765&HistoricalAwards=false
• 关键词: Multiphase; Separation; Control; Serially; Produced

The Chemical Structure, Dynamics and Mechanisms-B Program supports the fundamental research by Professor Alexander Greer at the City University of New York, Brooklyn College. Professor Greer develops techniques for accurately studying the chemistry of reactive oxygen-containing species, often called reactive oxygen intermediates (ROIs). ROIs are important in synthetic chemistry and are critical to understanding the aging processes in biology and in the environment. This research seeks to resolve mechanistic questions in ROI chemistry by using newly synthesized micro- and nanoparticles. Further scientific impact comes from designing materials which are resistant to aging caused by exposure to light and oxygen. The project supports training of research students. Professor Greer cultivates STEM talent and enthusiasm for the sciences within a wider and younger audience by expanding the American Society of Photobiology's program "Photobiology for Kids", among other educational efforts in collaboration with Brooklyn College?s Annual High School Chemistry Day. Reactive oxygen intermediates (ROIs; oxygen radicals and singlet oxygen) are prevalent in the field of aerobic photochemistry, but they have proven extremely difficult to study. Many primary light-dependent and secondary ROIs generation events remain undefined. At present, photosensitization has been used with conventional methods of production, such as homogeneous solution, which leads to complex mixtures of ROIs. This research seeks to understand the downstream reactions that follow initial photooxidation events and to control the oxidation of natural and synthetic molecules, to reduce toxicity to organisms and damage to materials, and to develop new methods for disinfection of water supplies. This fundamental research may also lead to new processes for the rapid photodegradation of plastics in landfills and oceans. New heterogeneous methods for the photogeneration of reactive oxygen intermediates are investigated, allowing the ROIs to be rationally manipulated with effective tuning of reactivity. The research provides a method for phase separation that facilitates the deconvolution of complex photochemical processes. One key feature of studying downstream reactions of primarily formed peroxides is the ability to gain insight into multistage oxidative events.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

化学结构、动力学和机制-B 项目支持纽约城市大学布鲁克林学院 Alexander Greer 教授的基础研究。格里尔教授开发了精确研究含活性氧物质（通常称为活性氧中间体（ROI））化学的技术。 ROI 在合成化学中很重要，对于理解生物学和环境中的衰老过程至关重要。这项研究旨在通过使用新合成的微米颗粒和纳米颗粒来解决 ROI 化学中的机械问题。进一步的科学影响来自于设计能够抵抗因暴露于光和氧气而引起的老化的材料。该项目支持研究生的培训。 格里尔教授通过扩大美国光生物学会的“儿童光生物学”项目以及与布鲁克林学院年度高中化学日合作的其他教育工作，在更广泛和更年轻的受众中培养 STEM 人才和对科学的热情。 活性氧中间体（ROI；氧自由基和单线态氧）在有氧光化学领域很普遍，但事实证明它们极难研究。许多依赖光的主要和次要 ROI 生成事件仍未定义。目前，光敏化已用于常规生产方法，例如均相溶液，这会导致 ROI 的复杂混合物。这项研究旨在了解初始光氧化事件后的下游反应，控制天然和合成分子的氧化，减少对生物体的毒性和对材料的损害，并开发供水消毒的新方法。 这项基础研究还可能带来垃圾填埋场和海洋中塑料快速光降解的新工艺。 研究了活性氧中间体光生成的新异质方法，通过有效调节反应性，可以合理地操纵 ROI。该研究提供了一种相分离方法，有助于复杂光化学过程的反卷积。研究主要形成的过氧化物的下游反应的一个关键特征是能够深入了解多阶段氧化事件。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Interparticle Delivery and Detection of Volatile Singlet Oxygen at Air/Solid Interfaces

空气/固体界面处挥发性单线态氧的颗粒间传递和检测

• DOI: 10.1021/acs.est.0c07922
• 发表时间: 2021-03
• 期刊: Environmental Science & Technology
• 影响因子: 11.4
• 作者: Durantini, Andrés M.;Greer, Alexander
• 通讯作者: Greer, Alexander

A Singlet Oxygen Priming Mechanism: Disentangling of Photooxidative and Downstream Dark Effects

单线态氧引发机制：解开光氧化和下游暗效应

• DOI: 10.1021/acs.joc.0c01712
• 发表时间: 2020-10
• 期刊: The Journal of Organic Chemistry
• 作者: Jabeen, Shakeela;Farag, Maria;Malek, Belaid;Choudhury, Rajib;Greer, Alexander
• 通讯作者: Greer, Alexander

Heck reaction synthesis of anthracene and naphthalene derivatives as traps and clean chemical sources of singlet molecular oxygen in biological systems

赫克反应合成蒽和萘衍生物作为生物系统中单线态分子氧的陷阱和清洁化学源

• DOI: 10.1039/d0pp00153h
• 发表时间: 2020-11
• 期刊: Photochemical & Photobiological Sciences
• 影响因子: 3.1
• 作者: Oliveira, Marilene Silva;Chorociejus, Gabriel;Angeli, José Pedro;Vila Verde, Giuliana;Aquino, Gilberto L.;Ronsein, Graziella E.;Oliveira, Maurício César;Barbosa, Livea F.;Medeiros, Marisa H.;Greer, Alexander;et al
• 通讯作者: et al

Dark-Binding Process Relevant to Preventing Photosensitized Oxidation: Conformation-Dependent Light and Dark Mechanisms by a Dual-Functioning Diketone

与防止光敏氧化相关的暗结合过程：双功能二酮的构象依赖性光和暗机制

• DOI: 10.1021/acsomega.9b03488
• 发表时间: 2019-12
• 期刊: ACS Omega
• 影响因子: 4.1
• 作者: Belh, Sarah J.;Walalawela, Niluksha;Lekhtman, Stas;Greer, Alexander
• 通讯作者: Greer, Alexander

Violet‐blue Light Induces “Natural” Photodynamic Plasma Disinfection with Endogenous Sensitizers

紫罗兰色蓝光诱导内源性敏化剂的自然光动力等离子体消毒

• DOI: 10.1111/php.13591
• 发表时间: 2022-02
• 期刊: Photochemistry and Photobiology
• 影响因子: 3.3
• 作者: Greer; Alexander
• 通讯作者: Alexander