Investigating organocatalytic routes to degradable polyacetals and polythioacetals

研究可降解聚缩醛和聚硫缩醛的有机催化路线

基本信息

批准号：
1904932
负责人：
Robert Grubbs
金额：
$ 41.21万
依托单位：
SUNY at Stony Brook
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1904932&HistoricalAwards=false
关键词：
Investigating organocatalytic routes degradable polyacetals

项目摘要

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry, Professors Robert B. Grubbs and Surita R. Bhatia of the Department of Chemistry at Stony Brook University are developing new synthetic routes for the construction of sustainable and biodegradable polymer-based materials. Polymers or plastics consisting of many repeating units linked with carbon-carbon bonds have benefited our society in many different ways. Due to its light weight, durability and ability to conform to shape, plastic has helped aerospace technologies take giant steps forward over the past 50 years, including advancements in satellites, shuttles, aircraft, and missiles. In addition, the building and construction, electronics, packaging, and transportation industries have all benefited greatly from plastic materials. While chemists have created numerous ways to assemble carbon-carbon units into polymers, methodologies to disassemble them one-by-one are still very rare. This reverse process is crucial because it leads to polymer recyclability, therefore providing a green life-cycle for plastics that would otherwise accumulate in the environment. This project addresses the molecular recycling of polymers by providing new synthetic routes for the preparation of polymeric materials with programmable degradability. New classes of polymers that result from this work are expected to retain the physical properties of current plastics but with the added benefit of being recyclable. This work provides training and education to undergraduate and graduate students in synthetic polymer chemistry, and collaborative research activities involving researchers from underrepresented groups at a historically Black university (Prairie View University). This research is focused on the design and synthesis of polymers modeled on existing acrylate and methacrylate backbones with the potential for similar physical and responsive properties but with programmable degradability. The research activities focus on the systematic investigation of the effects of initiators (alcohols and hydroxyl-terminated polymers), catalysts (triethylamines and other organic bases), and monomer structure (glyoxylate and glyoxamide monomers) on the control of the polymerization process. The incorporation of these different polyacetal and polythioacetal blocks with other polymer blocks into block copolymers is also investigated. The research is innovative and focuses on the properties and degradation of a class of polymers with high potential for industrial importance. The synthesized polymers are expected to have tunable thermoresponsivity, hydrophilicity, hydrophobicity and to be susceptible to photoinduced cleavage/degradation by acid.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在该化学系的大分子，超分子和纳米化学计划资助的该项目中，斯托尼·布鲁克大学化学系的罗伯特·B·格鲁布斯教授和苏里塔·R·巴蒂亚（Surita R. 聚合物或塑料由许多与碳碳键相关的重复单元组成的聚合物或塑料以许多不同的方式使我们的社会受益。由于其重量轻，耐用性和符合形状的能力，塑料帮助航空技术在过去50年中迈出了巨大的步骤，包括卫星，班车，飞机和导弹的进步。此外，建筑物，建筑，电子产品，包装和运输行业都从塑料材料中受益匪浅。尽管化学家创造了多种方法将碳碳单元组装成聚合物中，但一对一拆卸它们的方法仍然非常罕见。这种反向过程至关重要，因为它导致聚合物可回收性，因此为塑料提供了绿色生命周期，否则将在环境中积累。该项目通过提供具有可编程降解性的聚合物材料的新合成途径来解决聚合物的分子回收。这项工作产生的新类型聚合物有望保留当前塑料的物理特性，但具有可回收的额外好处。这项工作为合成聚合物化学的本科生和研究生提供了培训和教育，以及涉及历史悠久的黑人大学（Prairie View University）中代表性不足小组的研究人员的合作研究活动。这项研究的重点是以现有丙烯酸酯和甲基丙烯酸酯骨架建模的聚合物的设计和合成，具有相似的物理和响应性能但具有可编程可降解性的潜力。研究活动的重点是对发起人（醇和羟基终止聚合物），催化剂（三乙胺和其他有机碱）以及单体结构（乙酰乙二醇和乙酰胺单体）对聚合过程控制的影响的系统研究。还研究了这些不同的多乙酰座和聚乙酰座块与其他聚合物块的结合到块共聚物中。这项研究具有创新性，并着重于具有高潜力工业重要性的一类聚合物的特性和降解。预计合成的聚合物将具有可调的热响应性，亲水性，疏水性，并容易受到酸光诱导的裂解/降解的影响。该奖项反映了NSF的法定任务，并被认为是通过基金会的智力优点和广泛的影响来评估CRITERIA的智力功能和广泛影响。