Fouling resistant, freestanding zwitterionic polysulfones for osmotically driven membrane processes

用于渗透驱动膜工艺的防垢、独立式两性离子聚砜

• 批准号: 1836719
• 负责人: Matthew Green
• 金额: $ 31.12万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1836719&HistoricalAwards=false
• 关键词: Fouling; resistant; freestanding; zwitterionic; polysulfones

Providing sustainable and secure access to potable water is a critical challenge facing this generation. Natural water sources are treated to remove salt, organic matter, and biological organisms. As water demand increases, water sources that require more rigorous pretreatment must be utilized. Polymer membranes are a promising technology for these more rigorous water purification demands, as they selectively transport purified water while rejecting contaminants. Although promising, current membranes face two profound limitations: adhesion and growth of biological films on the membrane, and membrane degradation by chlorine. Both effects reduce membrane performance and increase cost due to the need to clean or replace the membrane. This project will design and test new polymeric membrane materials that retain the performance of commercial membranes, with molecular-level modification of the polymer for increased resistance to fouling by biofilms and decreased degradation by chlorine. Through an integration of macromolecular and process engineering, this project will investigate how molecular level polymeric design impacts processing, microstructure, and separation performance. Poly(arylene ether sulfone) precursors will be modified using post-polymerization modifications to introduce sulfobetaine zwitterions and a series of crosslinkers. The charge and crosslink densities will be optimized to balance hydrophilicity and water sorption versus swelling that leads to a loss of mechanical stability. Then, (anti)fouling mechanisms for the new membranes will be probed, including the role of surface roughness, hydrophilicity, and charge content on protein adhesion. Also, the influence of systematic changes in charge content on physical membrane characteristics will be studied, including water permeability, salt rejection at various salt concentrations and pressure drops, membrane porosity, free volume, morphology, and separation/process costs. Finally, the charge content and processing conditions will be correlated to membrane longevity, specifically structural integrity at various transmembrane pressure drops for asymmetric membranes, resistance to chlorine-mediated oxidative degradation, and long-term fouling studies. One graduate student will be trained in this project and undergraduate students will be involved in the laboratory work. An educational outreach plan is included that will engage the diverse student body of Arizona State University and the surrounding metropolitan community.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

提供可持续和安全的饮用水是这一代人面临的一项重大挑战。天然水源经过处理以去除盐、有机物和生物有机体。随着需水量的增加，必须利用需要更严格预处理的水源。聚合物膜是满足这些更严格的水净化要求的一项有前景的技术，因为它们可以选择性地输送净化水，同时拒绝污染物。尽管前景广阔，但当前的膜面临两个严重的限制：生物膜在膜上的粘附和生长，以及膜被氯降解。由于需要清洁或更换膜，这两种效应都会降低膜的性能并增加成本。该项目将设计和测试新型聚合物膜材料，这些材料保留了商业膜的性能，并对聚合物进行分子级改性，以提高对生物膜污染的抵抗力并减少氯的降解。通过大分子和工艺工程的整合，该项目将研究分子级聚合物设计如何影响加工、微观结构和分离性能。聚（亚芳基醚砜）前体将使用聚合后改性进行改性，以引入磺基甜菜碱两性离子和一系列交联剂。电荷和交联密度将被优化，以平衡亲水性和吸水性与导致机械稳定性损失的膨胀。然后，将探讨新膜的（防）污染机制，包括表面粗糙度、亲水性和电荷含量对蛋白质粘附的作用。此外，还将研究电荷含量的系统变化对物理膜特性的影响，包括透水性、各种盐浓度和压降下的脱盐率、膜孔隙率、自由体积、形态和分离/工艺成本。最后，电荷含量和处理条件将与膜寿命相关，特别是非对称膜在各种跨膜压降下的结构完整性、对氯介导的氧化降解的抵抗力以及长期污垢研究。该项目将培养一名研究生，本科生将参与实验室工作。其中包括一项教育推广计划，该计划将吸引亚利桑那州立大学和周边大都市社区的多元化学生群体。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Photocurable Poly(ethylene glycol) Diacrylate Resins with Variable Silica Nanoparticle Loading

具有可变二氧化硅纳米颗粒负载量的光固化聚乙二醇二丙烯酸酯树脂

• DOI: 10.1021/acs.iecr.9b02068
• 发表时间: 2019-07-18
• 期刊: Industrial & Engineering Chemistry Research
• 影响因子: 4.2
• 作者: Alexis Hocken;Yezhou Yang;F. Beyer;B. Morgan;K. Kline;T. Piper;M. Green
• 通讯作者: M. Green

Succinate in the tumor microenvironment affects tumor growth and modulates tumor associated macrophages

肿瘤微环境中的琥珀酸影响肿瘤生长并调节肿瘤相关巨噬细胞

• DOI: 10.1016/j.biomaterials.2023.122292
• 发表时间: 2023-10
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Inamdar, Sahil;Suresh, Abhirami P.;Mangal, Joslyn L.;Ng, Nathan D.;Sundem, Alison;Behbahani, Hoda Shokrollahzadeh;Rubino, Thomas E.;Yaron, Jordan R.;Khodaei, Taravat;Green, Matthew;et al
• 通讯作者: et al

Covalently integrated silica nanoparticles in poly(ethylene glycol)-based acrylate resins: thermomechanical, swelling, and morphological behavior

聚乙二醇丙烯酸酯树脂中的共价结合二氧化硅纳米颗粒：热机械、膨胀和形态行为

• DOI: 10.1039/d1sm01377g
• 发表时间: 2022-02
• 期刊: Soft Matter
• 影响因子: 3.4
• 作者: Hocken, Alexis;Beyer, Frederick L.;Lee, Jae Sang;Grim, Bradley J.;Mithaiwala, Husain;Green, Matthew D.
• 通讯作者: Green, Matthew D.

Thermodynamic interference with bile acid demicelleization reduces systemic entry and injury during cholestasis

胆汁酸去胶束的热力学干扰可减少胆汁淤积期间的全身进入和损伤

• DOI: 10.1038/s41598-020-65451-w
• 发表时间: 2020-12
• 期刊: Scientific Reports
• 影响因子: 4.6
• 作者: de Oliveira, Cristiane;Khatua, Biswajit;El;Patel, Krutika;Mishra, Vivek;Navina, Sarah;Grim, Bradley J.;Gupta, Srishti;Belohlavek, Marek;Cherry, Brian;et al
• 通讯作者: et al

Crosslinked electrospun composite membranes of poly(vinyl alcohol) and poly(vinyl chloride): tunable mechanical properties, porosity and performance

聚（乙烯醇）和聚（氯乙烯）交联电纺复合膜：可调节的机械性能、孔隙率和性能

• DOI: 10.1002/pi.6224
• 发表时间: 2021-03-17
• 期刊: Polymer International
• 影响因子: 3.2
• 作者: Husain Mithaiwala;Zachary Tronstad;M. M. Korah;Ale;er N. Buffington;er;M. Green
• 通讯作者: M. Green