MRI: Acquisition of Time of Flight-Inductively Coupled Plasma-Mass Spectrometer to support multi-disciplinary research and training in South Carolina and Nationw

MRI：购买飞行时间电感耦合等离子体质谱仪以支持南卡罗来纳州和全国的多学科研究和培训

• 批准号: 1828055
• 负责人: Mohammed Baalousha
• 金额: $ 63.59万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828055&HistoricalAwards=false
• 关键词: MRI; Acquisition; Time; Flight; Inductively

This award will permit the acquisition of a time of flight-inductively coupled plasma-mass spectroscopy (TOF-ICP-MS). In general, ICP-MS is widely used to analyze metal isotopes in complex matrices after complete digestion into dissolved form. Although this form of ICP-MS analysis remains commonly used, alternative sampling approaches that produce transient (as short as 500 microseconds) signals are being adapted extensively, such as single particle and single cell ICP-MS analysis. Sequential scanning ICP-MS instrumentations are limited to measuring transient signals of one element only. However, many materials are composed of multi elements. The TOF-ICP-MS allow: 1) full simultaneous detection of the entire mass spectrum of elements from Li to U for every single measurement in less than 50 microseconds; 2) multi-element determinations in fast transient signals such as single particles and single cells; 3) improved precision, particularly for measuring isotope ratios; 4) real-time internal standardization; and 5) untargeted analysis, i.e., identifying analytes in a sample without a priori knowledge of analytes in the sample. The acquisition of the TOF-ICP-MS will fill a crucial gap in elemental analytical facilities at the University of South Carolina by enabling simultaneous, untargeted, multi-element analysis of transient signals. The acquisition of TOF-ICP-MS will enhance on-going fundamental studies and support diverse applications including: 1) characterization of natural nanoparticles (NNPs) to better understand their properties, environmental behaviors/functions, and environmental and human health implications; 2) characterization of engineered (ENPs) to underpin development of new ENPs and assess environmental ENP exposure for potential environmental and human health implications; 3) characterization of incidental nanoparticles (INPs) to understand the fate and behavior of metals in aerosols emitted during combustion and thermal processing of wastes and their impact on air quality; and 4) provide analytical support for the NSF-funded Virginia Tech National Center for Earth and Environmental Nanotechnology Infrastructure (NanoEarth). These projects are at the forefront of their respective fields, yet their continued success hinges on ready access to the proposed instrumentation. The acquisition of the TOF-ICP-MS will enhance and accelerate existing collaborations between the PI and faculty, federal agencies (EPA, NIST and USGS), and NanoEarth, and will allow the researchers to establish new collaborations with other institutions nationally and internationally.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项将允许购买飞行时间电感耦合等离子体质谱仪 (TOF-ICP-MS)。一般来说，ICP-MS 广泛用于分析完全消化成溶解形式的复杂基质中的金属同位素。尽管这种形式的 ICP-MS 分析仍然普遍使用，但产生瞬态（短至 500 微秒）信号的替代采样方法正在被广泛采用，例如单颗粒和单细胞 ICP-MS 分析。顺序扫描 ICP-MS 仪器仅限于测量一种元素的瞬态信号。然而，许多材料是由多种元素组成的。 TOF-ICP-MS 可以：1）在不到 50 微秒的时间内对每次测量的从 Li 到 U 的元素的整个质谱进行完全同步检测； 2）单颗粒、单细胞等快速瞬态信号的多元素测定； 3) 提高精度，特别是测量同位素比； 4）实时内部标准化； 5)非目标分析，即在没有样品中分析物的先验知识的情况下识别样品中的分析物。收购 TOF-ICP-MS 将能够对瞬态信号进行同步、非目标、多元素分析，从而填补南卡罗来纳大学元素分析设施的关键空白。收购 TOF-ICP-MS 将加强正在进行的基础研究并支持多种应用，包括：1) 天然纳米颗粒 (NNP) 的表征，以更好地了解其特性、环境行为/功能以及环境和人类健康影响； 2) 工程化 (ENP) 的表征，以支持新 ENP 的开发并评估环境 ENP 暴露对环境和人类健康的潜在影响； 3) 偶然纳米粒子（INP）的表征，以了解废物燃烧和热处理过程中排放的气溶胶中金属的归宿和行为及其对空气质量的影响； 4) 为 NSF 资助的弗吉尼亚理工大学国家地球与环境纳米技术基础设施中心 (NanoEarth) 提供分析支持。这些项目处于各自领域的前沿，但它们的持续成功取决于是否可以随时使用拟议的仪器。 收购 TOF-ICP-MS 将加强和加速 PI 与教师、联邦机构（EPA、NIST 和 USGS）以及 NanoEarth 之间的现有合作，并使研究人员能够与国内外其他机构建立新的合作。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Unveiling elemental fingerprints: A comparative study of clustering methods for multi-element nanoparticle data

揭示元素指纹：多元素纳米颗粒数据聚类方法的比较研究

• DOI: 10.1016/j.scitotenv.2023.167176
• 发表时间: 2023-12
• 期刊: Science of The Total Environment
• 影响因子: 9.8
• 作者: Erfani, Mahdi;Baalousha, Mohammed;Goharian, Erfan
• 通讯作者: Goharian, Erfan

Elemental fingerprints in natural nanomaterials determined using SP-ICP-TOF-MS and clustering analysis

使用 SP-ICP-TOF-MS 和聚类分析测定天然纳米材料中的元素指纹

• DOI: 10.1016/j.scitotenv.2021.148426
• 发表时间: 2021-10
• 期刊: Science of The Total Environment
• 影响因子: 9.8
• 作者: Baalousha, Mohammed;Wang, Jingjing;Erfani, Mahdi;Goharian, Erfan
• 通讯作者: Goharian, Erfan

Wildland-urban interface fire ashes as a major source of incidental nanomaterials

荒地-城市界面火灰是附带纳米材料的主要来源

• DOI: 10.1016/j.jhazmat.2022.130311
• 发表时间: 2023-02
• 期刊: Journal of Hazardous Materials
• 影响因子: 13.6
• 作者: Alshehri, Talal;Wang, Jingjing;Singerling, Sheryl A.;Gigault, Julien;Webster, Jackson P.;Matiasek, Sandrine J.;Alpers, Charles N.;Baalousha, Mohammed
• 通讯作者: Baalousha, Mohammed

Multi-method approach for analysis of road dust particles: elemental ratios, SP-ICP-TOF-MS, and TEM

道路灰尘颗粒分析的多方法：元素比、SP-ICP-TOF-MS 和 TEM

• DOI: 10.1039/d2en00409g
• 发表时间: 2022-10
• 期刊: Environmental Science: Nano
• 作者: Tou, Feiyun;Nabi, Md. Mahmudun;Wang, Jingjing;Erfani, Mahdi;Goharian, Erfan;Chen, Jing;Yang, Yi;Baalousha, Mohammed
• 通讯作者: Baalousha, Mohammed

Analysis of complex particle mixtures by asymmetrical flow field-flow fractionation coupled to inductively coupled plasma time-of-flight mass spectrometry

通过不对称流场流分级与电感耦合等离子体飞行时间质谱分析复杂颗粒混合物

• DOI: 10.1016/j.chroma.2021.461981
• 发表时间: 2021-03
• 期刊: Journal of Chromatography A
• 影响因子: 4.1
• 作者: Meili;Meier, Florian;Drexel, Roland;Baalousha, Mohammed;Flamigni, Luca;Hegetschweiler, Andreas;Kraus, Tobias
• 通讯作者: Kraus, Tobias