SCH: INT: Transabdominal Fetal Oximetry for Improved Intrapartum Fetal Monitoring

SCH：INT：经腹胎儿血氧测定法改善产时胎儿监测

基本信息

批准号：
1838939
负责人：
Soheil Ghiasi
金额：
$ 120万
依托单位：
University of California-Davis
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1838939&HistoricalAwards=false
关键词：
SCH INT Transabdominal Fetal Oximetry

项目摘要

This project will improve the current state of fetal health monitoring during labor and delivery, an healthcare issue that touches almost every family. Since introduction of electronic fetal monitoring (EFM) to the labor and delivery rooms about half a century ago, the national rate of Cesarean section deliveries has risen five-fold. The main need driving Cesarean sections is a concern for oxygen deprivation in the fetsus' brain or hypoxic brain injury. These injuries result in problems such as cerebral palsy. While the number of Cesarean sections has increased, the rates of various health conditions associated hypoxia remain unchanged. The fundamental problem with EFM is that besides hypoxia, a number of innocuous factors can cause alarming EFM traces, which may lead to unnecessary medical interventions. The project aims to address this problem by research, development and validation of technology for non-invasive transabdominal measurement of fetal arterial blood oxygen saturation. Furthermore, the project includes specific education and outreach activities that are driven by integration of research results into courses, and recruitment and retention of students from underrepresented backgrounds into STEM education.This proposal to address these issues through development of non-invasive measurement of fetal blood oxygen saturation. The project develops a comprehensive set of tissue models that consider inter-patient variation and intrapartum dynamics, to allow investigation of the fundamentals of light propagation in the abdominal area in the context of labor and delivery. The project involves shining near infrared light at several carefully selected wavelengths into the maternal abdomen, followed by transabdominal sensing of diffuse reflectance light, and isolation of very weak fetal photo-plethysmographs from the maternal and other noises contributing to the sensed signal. Several approaches to improve system robustness in face of intrapartum dynamics, such as adaptive noise canceling, time-resolved spectroscopy for dynamic calibration, and correlated measurements via a sensor array will be investigated. An extensive evaluation plan involving hypoxic pregnant sheep models and human subjects will be carried out.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目将改善人工和分娩期间胎儿健康监测的现状，这是一个几乎每个家庭的医疗保健问题。自从大约半个世纪前向劳动力和分娩室引入电子胎儿监测（EFM）以来，剖宫产的全国性率提高了五倍。驾驶剖宫产的主要需求是狂热的脑部或低氧脑损伤中的氧气缺乏。这些伤害导致脑瘫等问题。虽然剖宫产的数量有所增加，但各种健康状况的比率仍然没有改变。 EFM的基本问题是，除了缺氧之外，许多无害的因素可能导致EFM痕迹令人震惊，这可能导致不必要的医疗干预措施。该项目旨在通过研究，开发和验证技术来解决此问题，以实现胎儿动脉血氧饱和度的非侵入性经腹测量。此外，该项目还包括由将研究结果整合到课程中的特定教育和外展活动，以及从代表性不足的背景中招募和保留学生对STEM教育的招聘和保留。该提案通过对胎儿血氧饱和度进行非侵入性测量来解决这些问题。该项目开发了一组全面的组织模型，这些模型考虑了患者间变化和产前动力学，以便在劳动和分娩的背景下研究腹部中光传播的基础。该项目涉及在几个精心挑选的波长中近红外光线闪闪发光的光线，然后在腹部腹部进行腹部传感，弥散性反射光，以及从母体和其他噪音中分离出非常弱的胎儿光静脉造影仪，从而有助于感应信号。面对原始动力学，将研究几种改善系统鲁棒性的方法，例如自适应噪声取消，用于动态校准的时间分辨光谱以及通过传感器阵列的相关测量值。将制定一项涉及缺氧怀孕模型和人类受试者的广泛评估计划。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的评估标准来通过评估来支持的。