SCH: INT: Transabdominal Fetal Oximetry for Improved Intrapartum Fetal Monitoring

SCH：INT：经腹胎儿血氧测定法改善产时胎儿监测

基本信息

批准号：
1838939
负责人：
Soheil Ghiasi
金额：
$ 120万
依托单位：
University of California-Davis
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1838939&HistoricalAwards=false
关键词：
SCH INT Transabdominal Fetal Oximetry

项目摘要

This project will improve the current state of fetal health monitoring during labor and delivery, an healthcare issue that touches almost every family. Since introduction of electronic fetal monitoring (EFM) to the labor and delivery rooms about half a century ago, the national rate of Cesarean section deliveries has risen five-fold. The main need driving Cesarean sections is a concern for oxygen deprivation in the fetsus' brain or hypoxic brain injury. These injuries result in problems such as cerebral palsy. While the number of Cesarean sections has increased, the rates of various health conditions associated hypoxia remain unchanged. The fundamental problem with EFM is that besides hypoxia, a number of innocuous factors can cause alarming EFM traces, which may lead to unnecessary medical interventions. The project aims to address this problem by research, development and validation of technology for non-invasive transabdominal measurement of fetal arterial blood oxygen saturation. Furthermore, the project includes specific education and outreach activities that are driven by integration of research results into courses, and recruitment and retention of students from underrepresented backgrounds into STEM education.This proposal to address these issues through development of non-invasive measurement of fetal blood oxygen saturation. The project develops a comprehensive set of tissue models that consider inter-patient variation and intrapartum dynamics, to allow investigation of the fundamentals of light propagation in the abdominal area in the context of labor and delivery. The project involves shining near infrared light at several carefully selected wavelengths into the maternal abdomen, followed by transabdominal sensing of diffuse reflectance light, and isolation of very weak fetal photo-plethysmographs from the maternal and other noises contributing to the sensed signal. Several approaches to improve system robustness in face of intrapartum dynamics, such as adaptive noise canceling, time-resolved spectroscopy for dynamic calibration, and correlated measurements via a sensor array will be investigated. An extensive evaluation plan involving hypoxic pregnant sheep models and human subjects will be carried out.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目将改善分娩期间胎儿健康监测的现状，这是一个几乎涉及每个家庭的医疗保健问题。自从大约半个世纪前在产房和产房引入胎儿电子监护 (EFM) 以来，全国剖腹产率上升了五倍。剖腹产的主要需求是担心胎儿大脑缺氧或缺氧性脑损伤。这些伤害会导致脑瘫等问题。尽管剖腹产手术的数量有所增加，但与缺氧相关的各种健康状况的发生率却保持不变。 EFM 的根本问题是，除了缺氧之外，许多无害因素也会导致令人担忧的 EFM 痕迹，从而可能导致不必要的医疗干预。该项目旨在通过研究、开发和验证胎儿动脉血氧饱和度的无创经腹测量技术来解决这一问题。此外，该项目还包括具体的教育和外展活动，这些活动是通过将研究成果整合到课程中以及招募和保留来自代表性不足背景的学生进入 STEM 教育来推动的。该提案旨在通过开发胎儿血液的非侵入性测量来解决这些问题氧饱和度。该项目开发了一套全面的组织模型，考虑了患者间的差异和产时动态，以便研究临产和分娩背景下腹部区域光传播的基本原理。该项目涉及将几个精心选择的波长的近红外光照射到孕妇腹部，然后对漫反射光进行经腹感测，并将非常微弱的胎儿光电体积描记器与孕妇和其他有助于感测信号的噪音隔离。将研究几种提高系统在产时动态方面的鲁棒性的方法，例如自适应噪声消除、用于动态校准的时间分辨光谱以及通过传感器阵列的相关测量。将开展一项涉及缺氧怀孕绵羊模型和人类受试者的广泛评估计划。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。