RCN-UBE Incubator: Preparing a Network to Develop Molecular Case Studies at the Interface of Biology and Chemistry

RCN-UBE 孵化器：准备网络以开发生物学和化学交叉点的分子案例研究

• 批准号: 1827011
• 负责人: Shuchismita Dutta
• 金额: $ 7.5万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1827011&HistoricalAwards=false
• 关键词: RCN; UBE; Incubator; Preparing; Network

Understanding structure-function relationships is foundational to learning biology. In lower-division courses, students study the shapes and functions of selected proteins and nucleic acids. However, deep understanding of structure-function relationships requires visualizing the structure, mapping information from various biological data resources (e.g., polymer sequence, interactions, mutations, variations) onto the structure, and applying biology and/or chemistry knowledge to synthesize explanations of function. Unfortunately, these activities are not common in undergraduate biology curricula. Collaboration between biology, chemistry, and biochemistry educators to adapt molecular visualization approaches currently being used in chemistry can benefit biology education. To that end, the aim of this project is to establish a network of interested faculty that will create case studies, an effective active-learning technique, to teach the relationship between molecular structure and function. The cases will enable students to visualize and analyze challenging real-world problems in atomic detail and apply their biology and/or chemistry knowledge to develop solutions. These molecular visualizations will provide a platform for integrating knowledge from different sub-disciplines of biology, such as biochemistry, genetics, and cell biology to form the foundation for practicing interdisciplinary, team science across STEM disciplines.This RCN-UBE project will establish a new network, Molecular CaseNet, to develop case studies at the interface of biology and chemistry. Objectives of the incubator phase of this project are to 1) bring together an interdisciplinary team of seven scientists and researchers to develop an exemplar for case-study design and determine format requirements for future case studies; 2) create two model case studies focused on specific biological processes/events and discussed at a molecular level; and 3) present the cases in community workshops and professional society meetings to recruit new members to the network and gather feedback on usability, clarity, and relevance of the case studies. Piloting the newly developed case studies with selected student groups will shed light on the relevance of these case studies in learning biology, chemistry, and biochemistry. By using the planned case studies, students with varied levels of expertise and disciplinary training will have the opportunity to understand molecular structure-function relationships and practice the scientific process to address real-world problems. In turn, this practice will help prepare the next generation of workers in STEM fields to creatively apply interdisciplinary approaches to problem-solving.This project is being jointly funded by the Directorate for Biological Sciences, Division of Biological Infrastructure, and the Directorate for Education and Human Resources, Division of Undergraduate Education as part of their efforts to address the challenges posed in Vision and Change in Undergraduate Biology Education: A Call to Action (http://visionandchange/finalreport/).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

了解结构功能关系是学习生物学的基础。在较低的课程中，学生研究选定的蛋白质和核酸的形状和功能。但是，对结构功能关系的深入了解需要可视化结构，从各种生物学数据资源（例如聚合物序列，相互作用，突变，变化）中绘制信息，以及将生物学和/或化学知识应用于功能的解释。不幸的是，这些活动在本科生物学课程中并不常见。生物学，化学和生物化学教育者之间的合作，以适应当前用于化学的分子可视化方法，可以使生物学教育受益。为此，该项目的目的是建立一个有兴趣的教师网络，该网络将创建案例研究，一种有效的主动学习技术，以教授分子结构与功能之间的关系。这些案例将使学生能够在原子细节中可视化和分析具有挑战性的现实世界问题，并运用其生物学和/或化学知识来开发解决方案。这些分子可视化将为整合不同生物学子学科的知识的平台，例如生物化学，遗传学和细胞生物学，构成了实践跨学科的，跨学科的团队科学的基础。该RCN-UBE项目将建立一个新的网络，建立一个新的网络，分子库，以开发生物学和化学界面的病例研究。该项目的孵化器阶段的目标是1）将一个由七位科学家和研究人员组成的跨学科团队组合在一起，以开发案例研究设计的典范，并确定未来案例研究的格式要求； 2）创建两个模型案例研究，重点是特定的生物过程/事件，并在分子层进行了讨论； 3）在社区研讨会和专业社会会议上介绍案件，以招募新成员进入网络，并收集有关案例研究的可用性，清晰度和相关性的反馈。通过选定的学生群体试行新开发的案例研究将阐明这些案例研究在学习生物学，化学和生物化学方面的相关性。通过使用计划的案例研究，具有不同水平的专业知识和纪律培训的学生将有机会了解分子结构 - 功能功能关系，并实践科学过程以解决现实世界中的问题。反过来，这种做法将有助于为STEM领域的下一代工人做好准备，以创造性地将跨学科的方法应用于问题解决方案。本项目由生物学科学局，生物基础设施局，生物学基础设施局共同资助，教育和人力资源局的努力，以挑战为挑战的一部分，以应对挑战的一部分： （http：// VisionandChange/finalReport/）。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，被认为值得通过评估获得支持。

项目成果

The Molecular Case Study Cycle

分子案例研究周期

• 发表时间: 2020
• 期刊: CCCE Newsletter
• 作者: Dutta, S.