Collaborative Research: Mechanical Characterization of Bio-Interfaces by Shear Wave Scattering

合作研究：通过剪切波散射对生物界面进行机械表征

基本信息

批准号：
1826214
负责人：
Melih Eriten
金额：
$ 32.3万
依托单位：
University of Wisconsin-Madison
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2022-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1826214&HistoricalAwards=false
关键词：
Collaborative Research Mechanical Characterization Bio

项目摘要

The normal mechanical properties of the tissues of the human body are often different from those of cancerous tumors. A goal of this research project is to create a new approach to measuring the mechanical properties of body tissues in living patients. An existing method to measure mechanical properties called "magnetic resonance (MR) elastography" is attractive because it does not use damaging radiation. However, it is not now sufficiently accurate to measure the interface properties between tumors and normal tissue. One of the problems to overcome is that MR elastography is accurate when tissue is uniform, but it is inaccurate at the interface between normal tissue and tumor. This interface inaccuracy makes it more difficult to see small tumors, exactly those that need to be detected for early treatment. This research project will determine experimentally why the image is degraded at an interface, and then create a theory to improve the images. The new method will be tested using real data collected from patients to determine if it improves imaging not only for the experimental system, but also for the patients. The research will support NSF's mission of promoting progress of science and contribute to the goal of advancing national health by enabling advances in medical technologies. This project will provide outreach, training and mentoring opportunities as well for a diverse group of K12, undergraduate and graduate research students. The research team will also collaborate with the national and international media to disseminate the findings to the public. This project will provide a novel methodology for relating mechanical strength and compliance of bio-interfaces to noninvasive wave scattering data, and thus provide safe means for diagnostics of physicochemical nature of such interfaces. In particular, wave-propagation across cohesive-frictional interfaces will be modeled, and a wave-scattering-based characterization methodology will be developed to identify the mechanical properties of the interfaces. Moreover, an advanced laser vibrometry technique (multipoint laser vibrometry) will be utilized to measure shear wave scattering across soft synthetic interfaces. Those measurements will serve as validation datasets for the characterization methodology. Lastly, the efficacy of the methodology will be tested with MR Elastography measurements. This final step will reveal the current limitations in practice, and provide guidelines for the next-generation of MR-based diagnostics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

人体组织的正常机械性能通常与癌性肿瘤的机械性能不同。该研究项目的一个目标是创建一种新的方法来测量活着的患者身体组织的机械性能。现有的测量称为“磁共振（MR）弹性图”的机械性能的方法很有吸引力，因为它不使用损坏的辐射。但是，现在不足以测量肿瘤和正常组织之间的界面特性。要克服的问题之一是，当组织均匀时，MR弹性学是准确的，但是在正常组织和肿瘤之间的界面不准确。这种界面不准确使得很难看到小肿瘤，正是那些需要检测到早期治疗的肿瘤。该研究项目将通过实验确定为什么在接口处降低图像的原因，然后创建一个理论来改进图像。新方法将使用从患者那里收集的实际数据进行测试，以确定其是否不仅改善了实验系统的成像，还可以改善患者的成像。该研究将支持NSF促进科学进步的使命，并通过实现医疗技术进步来促进国家健康的目标。该项目将为多元化的K12，本科和研究生研究专业的学生提供外展，培训和指导机会。研究团队还将与国家和国际媒体合作，向公众传播这些发现。该项目将提供一种新的方法，以将生物互化的机械强度和合规性与非侵入性波散射数据联系起来，从而为此类接口的物理化学性质诊断提供安全手段。特别是，将建模跨内聚界面界面的波传播，并将开发基于波浪的表征方法来识别接口的机械性能。此外，将利用先进的激光振动学技术（多点激光振动法）来测量跨软合成接口的剪切波散射。这些测量将用作表征方法的验证数据集。最后，该方法的功效将通过MR弹性学测量测试。这一最后一步将揭示当前实践中的局限性，并为基于MR的诊断的下一代提供指南。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的评估审查标准来评估值得支持的。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Brain-mimicking phantom for biomechanical validation of motion sensitive MR imaging techniques

用于运动敏感 MR 成像技术生物力学验证的仿脑模型

DOI：
10.1016/j.jmbbm.2021.104680
发表时间：
2021
期刊：
Journal of the Mechanical Behavior of Biomedical Materials
影响因子：
3.9
作者：
Ozkaya, E.;Triolo, E.R.;Rezayaraghi, F.;Abderezaei, J.;Meinhold, W.;Hong, K.;Alipour, A.;Kennedy, P.;Fleysher, L.;Ueda, J.
通讯作者：
Ueda, J.

Fracture-Induced Acoustic Emissions in Gelatin