Fur Anti-Fouling via Physiological Mechanisms

毛皮通过生理机制防污

• 批准号: 1825801
• 负责人: Ranajay Ghosh
• 金额: $ 44.98万
• 依托单位: The University of Central Florida Board of Trustees
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1825801&HistoricalAwards=false
• 关键词: Fur; Anti; Fouling; via; Physiological

Surfaces such as those of pipes, trees or stones that are frequently covered in water are highly vulnerable to the growth of extensive films of bacteria. Even though bacteria grow on almost everything that is frequently in the water, furry mammals who live in and around the water of ponds rivers, streams and the ocean do not suffer from thick bacterial films on their fur. Extensive growth of bacteria causes "biofouling," when the bacteria interfere with the function of a man-made system. The consequences of biofouling are of major concern as they include reduced hydrodynamic efficiency, reduced buoyancy, surface corrosion, flow blockage and contamination. The first bacteria that colonize a surface make a "primed surface" on which macroscale foulers (e.g., algae and barnacles) can congregate. It is the goal of this research to discover the combination of mechanisms that keep fur fouler-free. The study will address the commonly overlooked function of fur in mammalian survival, its ability to resist biofouling, thereby illuminating its role beyond insulation. A potential outcome of this research will be the discovery of new mechanisms to prevent to growth of bacteria on surfaces, which will further the economic goals of the United States by significantly reducing the need for surface maintenance for structures exposed to water. This work will enrich graduate and undergraduate curricula offered by the PI and Co-PIs. The project team will create an educational website, 'Hairy Tales,' to provide a platform for K-12 outreach related to this work. Focus will be given to providing research opportunities to minority students and students with diverse backgrounds via the University of Central Florida Office of Diversity and Inclusion.The intellectual merit of this research is the characterization of fur's resistance to biofouling by the consideration of its properties at various length scales, ranging from individual follicle texture and bending properties, to array morphology and aggregate texture. Fur's anti-fouling mechanisms will be characterized using representative furs from semi-aquatic and terrestrial mammals: North American beaver, river otter, sea otter, and caribou. By exposing these furs to three bacterial species that are common primary foulers, biofilm formation, persistence, and disruption will be measured and compared. Singular hairs submerged into liquid cultures containing proliferating bacteria will expose the possible effect of (1) fiber surface topology and (2) deformability on microbial attachment. Naturally arranged hides will (3) demonstrate the effectiveness of fiber-to-fiber contact to stunt bacterial proliferation and enable self-cleaning. Finally, (4) a fur's natural oils could impact fouler adhesion, which will be tested by comparing biofilm formation on untreated fibers to those cleaned of natural surfactants. These four experiments will unravel which physical mechanisms of fur predominately contribute to cleanliness.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

诸如经常被水覆盖的管道，树木或石头的表面非常容易受到广泛细菌膜的生长。即使细菌几乎在水中经常出现的东西上生长，但生活在池塘河流，溪流和海洋的水中和周围的毛茸茸的哺乳动物也不会遭受其毛皮上厚实的细菌膜。当细菌干扰人造系统的功能时，细菌的广泛生长会引起“生物污染”。 生物污染的后果是主要关注的，因为它们包括降低流体动力效率，浮力降低，表面腐蚀，流动阻塞和污染。第一个定居表面的细菌形成了宏观犯规者（例如藻类和藤壶）可以聚集的“底漆表面”。这项研究的目的是发现保持不含皮毛的机制的组合。该研究将解决毛皮在哺乳动物生存中通常被忽视的功能，其抵抗生物污染的能力，从而阐明其在绝缘之外的作用。这项研究的潜在结果将是发现新机制，以防止在表面上生长细菌的生长，这将通过大大减少暴露于水的结构的表面维护需求，从而进一步进一步实现美国的经济目标。这项工作将丰富PI和Co-Pis提供的研究生和本科课程。项目团队将创建一个教育网站“ Havery Tales”，为与这项工作相关的K-12外展提供平台。将重点放在通过佛罗里达大学多样性和包容性办公室为具有不同背景的少数族裔学生和不同背景的学生提供研究机会。这项研究的智力优点在于，通过以各种长度来考虑毛皮对生物污染的耐药性的特征，包括各个长度，包括单个卵泡质地和弯曲属性和弯曲的特性，到驱动式的物质质地。 Fur的抗污染机制将使用半节食和陆地哺乳动物的代表性皮草进行表征：北美海狸，水獭，海獭和驯鹿。通过将这些毛皮暴露于三种细菌物种中，这些细菌是常见的原发性犯规者，生物膜形成，持久性和破坏将被测量和比较。淹没在含有增殖细菌的液体培养物中的奇异头发将暴露（1）纤维表面拓扑结构和（2）对微生物附着的可变形性的可能影响。自然排列的生皮将（3）证明纤维对纤维接触与特技细菌增殖的有效性并实现自我清洁。最后，（4）毛皮的天然油可能会影响犯规的粘附，这将通过将未处理纤维的生物膜形成与清洁天然表面活性剂的生物膜形成进行测试。这四个实验将揭示哪种毛皮的物理机制主要有助于清洁。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的评估标准通过评估来支持的。

项目成果

Fouling of mammalian hair fibres exposed to a titanium dioxide colloidal suspension

• DOI: 10.1098/rsif.2021.0904
• 发表时间: 2022-04
• 期刊: Journal of the Royal Society Interface
• 影响因子: 3.9
• 作者: Milos Krsmanovic;Hessein Ali;Dipankar Biswas;Hossein Ebrahimi;Andrew K. Dickerson

Fur flutter in fluid flow fends off foulers

• DOI: 10.1098/rsif.2023.0485
• 发表时间: 2023-12
• 期刊: Journal of the Royal Society Interface
• 影响因子: 3.9
• 作者: Milos Krsmanovic;Ranajay Ghosh;Andrew K. Dickerson

Bending of biomimetic scale covered beams under discrete non-periodic engagement

• DOI: 10.1016/j.ijsolstr.2019.01.021
• 发表时间: 2019-07-01
• 期刊: INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
• 影响因子: 3.6
• 作者: Ali, Hessein;Ebrahimi, Hossein;Ghosh, Ranajay
• 通讯作者: Ghosh, Ranajay

Hydrodynamics and surface properties influence biofilm proliferation

• DOI: 10.1016/j.cis.2020.102336
• 发表时间: 2021-01-06
• 期刊: ADVANCES IN COLLOID AND INTERFACE SCIENCE
• 影响因子: 15.6
• 作者: Krsmanovic, Milos;Biswas, Dipankar;Dickerson, Andrew K.
• 通讯作者: Dickerson, Andrew K.

Frictional Damping from Biomimetic Scales

• DOI: 10.1038/s41598-019-50944-0
• 发表时间: 2019-10-10
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Ali, Hessein;Ebrahimi, Hossein;Ghosh, Ranajay
• 通讯作者: Ghosh, Ranajay