SBIR Phase I: Extended depth imaging with OCT

SBIR 第一阶段：使用 OCT 进行扩展深度成像

• 批准号: 1820008
• 负责人: William Brown
• 金额: $ 22.5万
• 依托单位: Lumedica, Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1820008&HistoricalAwards=false
• 关键词: SBIR; Phase; Extended; depth; imaging

This SBIR Phase I project will develop an extended depth imaging variation of optical coherence tomography (OCT). OCT is an optical imaging method that can visualize tissue structures up to 1mm deep with microscopic resolution. It has been well adapted for retinal imaging but although available for skin imaging application, the performance and price point are not sufficient to encourage market adoption. Building on NSF supported research at Duke University, this project will extend the depth range of OCT from the current 1-2 mm, which is only the most superficial layer of skin, to 3-4 mm, enabling full imaging of skin layers down to the dermal junction. This will enable dermatologists to access OCT without a large financial outlay and provide a non-invasive imaging modality in the office setting.Extended depth imaging is also applicable to dental imaging and may allow dentists to reduce the need for X-ray imaging by providing cross sectional images of teeth and gums. Since these OCT instruments are highly portable, the deep imaging system can be widely used, across lab benches, in the field or shared throughout a medical office. This project will support the development of new products and the teams that design and build them. Extended depth imaging OCT uses a novel design to dramatically increase the depth penetration of OCT into skin, teeth and other samples. By using distinct illumination and collection apertures, extended depth (or dual axis) OCT can triangulate the signal to layers deep beneath the tissue surface. Compared to previous OCT systems, this increases the imaging depth by a factor of 2. This innovation will be combined with proprietary spectrometer design, which was developed to take advantage of 3D printing methods, to develop a disruptive new instrument for imaging with the performance and price necessary for commercial success in clinical dermatology and dentistry. This proposal will build a prototype system and test it on several types of animal tissue.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个SBIR I期项目将发展光学相干断层扫描（OCT）的扩展深度成像变化。 OCT是一种光学成像方法，可以通过微分辨率可视化最高1mm的组织结构。它非常适合于视网膜成像，但尽管可用于皮肤成像的应用，但性能和价格点不足以鼓励采用市场。在NSF支持杜克大学的研究基础上，该项目将将OCT的深度范围从目前的1-2毫米（只是皮肤最浅层层）扩展到3-4毫米，从而使皮肤层的完整成像降至真皮交界处。这将使皮肤科医生能够在不大财务支出的情况下访问OCT，并在办公室设置中提供非侵入性成像方式。扩展的深度成像也适用于牙科成像，并可能允许牙医通过提供牙齿和牙龈的横截面图像来减少X射线成像的需求。由于这些OCT仪器非常便携，因此深层成像系统可以在实验室，在现场或整个医疗办公室共享。该项目将支持新产品的开发以及设计和建造它们的团队。扩展的深度成像OCT使用一种新颖的设计，可以显着增加OCT进入皮肤，牙齿和其他样品的深度渗透。通过使用明显的照明和收集孔，延长的深度（或双轴）OCT可以将信号三角剖分至组织表面深处的层。与以前的OCT系统相比，这将成像深度提高了2倍。这项创新将与专有光谱仪设计相结合，该设计旨在利用3D打印方法，以开发出一种颠覆性的新仪器，用于成像，其性能和价格在临床皮肤病学和牙科中的商业成功所必需的性能和价格。该提案将建立一个原型系统并对几种类型的动物组织进行测试。该奖项反映了NSF的法定任务，并且使用基金会的知识分子优点和更广泛的影响审查标准，被认为值得通过评估来获得支持。