SBIR Phase I: Enabling Cuffless Blood Pressure Monitoring with a Novel, Wearable RF-Based Sensor.

SBIR 第一阶段：使用新型可穿戴射频传感器实现无袖血压监测。

• 批准号: 1746660
• 负责人: Oliver Shay
• 金额: $ 22.5万
• 依托单位: Blumio, Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1746660&HistoricalAwards=false
• 关键词: SBIR; Phase; Enabling; Cuffless; Blood

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to achieve non-contact continuous blood pressure monitoring and address a critical need for personalized medicine for hypertension. For the first time, hypertensive individuals will have access to a comfortable, non-contact, continuous blood pressure monitoring device that allows for seamless blood pressure measurement without disturbing the user in any way. With 1 out of every 3 adults in the United States living with hypertension, The proposed innovation will meet an important need to monitor blood pressure continuously and noninvasively, thereby providing new insight into how one's blood pressure responds to medication, exercise, diet, and their actions. Longer term, the data collected by the team will yield unprecedented insight into short and long-term blood pressure rhythms and has the potential to revolutionize personalized medicine for hypertension. This technology is expected to empower people with the feedback that they need to understand what works for them as an individual to maintain their health.The proposed project will lay the ground work for the development of a continuous-wear blood pressure monitoring device suitable for everyday use. Through an RF sensor that can detect arterial movement, the proposed technology can measure cardiovascular parameters for every heartbeat. To date, a prototype sensor has shown significant promise at providing accurate blood pressure measurements in a small sample. Beyond blood pressure information, the fundamental capability of the proposed technology is to measure arterial stiffness, a critical indicator of cardiovascular health. With the support of this NSF grant, the team is expected to develop its technology and ready it for commercialization. The goal for this project is to: (1) eliminate first-surface reflections and micro-motion artifacts related to RF sensing; (2) refine blood pressure algorithms and compare measurements against gold standard BP measurements in healthy, hypotensive, and hypertensive populations. The proposed technology could become an important scientific tool to aid the advancement of cardiovascular research, enabling researchers and clinicians alike to gain further understanding of cardiovascular-related health parameter.

这项小型企业创新研究（SBIR）I阶段项目的更广泛的影响/商业潜力是实现非接触式连续血压监测，并解决对高血压的个性化医学的关键需求。高血压个体将首次获得舒适，非接触，连续的血压监测装置，该设备可以进行无缝的血压测量，而不会以任何方式打扰用户。在美国每3名成年人中，有1个患有高血压，拟议的创新将满足不断和无创的血压的重要需求，从而提供了有关人的血压如何应对药物，运动，饮食及其行为的新见解。从长远来看，团队收集的数据将对短期和长期的血压节奏产生前所未有的见解，并有可能彻底改变个性化医学以换取高血压。预计这项技术将使人们有能力的反馈意见，他们需要了解对他们作为一个个人维护健康有效的方法。拟议的项目将为开发适合日常使用的连续服装血压监测设备开发地面工作。通过可以检测动脉运动的RF传感器，提出的技术可以测量每个心跳的心血管参数。迄今为止，原型传感器在小样本中提供准确的血压测量方面表现出了巨大的希望。除了血压信息之外，该技术的基本能力是测量动脉僵硬，这是心血管健康的关键指标。在这项NSF赠款的支持下，该团队有望开发其技术并为商业化做好准备。该项目的目标是：（1）消除与RF感应相关的第一面反射和微动伪像； （2）在健康，低血压和高血压种群中，将血压算法与金标准BP测量进行比较。提出的技术可能成为帮助进步心血管研究的重要科学工具，使研究人员和临床医生都能够进一步了解与心血管相关的健康参数。