Meeting: Inside the black box: the mitochondrial basis of life-history variation and animal performance: January 3-7, 2018: San Francisco, CA

会议：黑匣子内部：生活史变异和动物表现的线粒体基础：2018 年 1 月 3 日至 7 日：加利福尼亚州旧金山

• 批准号: 1738378
• 负责人: Wendy Hood
• 金额: $ 1.48万
• 依托单位: Auburn University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1738378&HistoricalAwards=false
• 关键词: Meeting; Inside; black; box; mitochondrial

Mitochondria play a critical role in determining animal performance. Mitochondria produce cellular energy molecules that fuel nearly all organismal processes, but also are responsible for the production of reactive oxygen species - and in turn oxidative stress - an important contributor to senescence. As a result, variation in mitochondrial properties between individuals can predict differences in growth, reproduction, and rate of aging. While integrative measures of mitochondrial function are beginning to provide new insight, the theory and methods associated with these approaches are not widespread in the research community. To address this need, a symposium will be held at the national meeting of the Society for Integrative and Comparative Biology, Jan 3-7, 2018 in San Francisco, CA. The symposium is designed to aid networking among investigators and expand the appreciation of the ecological and evolutionary effects of mitochondrial function to a wider community. The symposium will include a wide diversity of scientists, including students and postdoctoral fellows. The invited speakers will be made up of an equal number of men and women ranging from the level of post-doc, through to assistant, associate, and full professors. Complementary oral and poster sessions will enable graduate and undergraduate students to participate in the symposium. All presenters in the main symposium and companion sessions will submit an article associated with their talk that will be published in a special issue of Integrative and Comparative Biology. Through this publication, the ideas presented in the main symposium will be disseminated to a larger audience and cumulatively provide a basis for future studies of mitochondrial function and life history variation.Mitochondria play a critical role in determining organismal performance through their production of ATP. But, they also generate reactive oxygen species - and in turn oxidative stress - an important contributor to senescence. As a result, variation in mitochondrial properties between individuals can predict differences in organismal maintenance, growth, and reproduction. Researchers have begun bringing measurements of mitochondrial function common to biomedical research to ecological and evolutionary studies. In addition, researchers have begun to evaluate the genetic basis and in turn heredity of mitochondrial performance via the intricate interactions between mitochondria and nuclear genes coding for the mitochondrial proteins. The integration of these measures with oxidative stress, metabolic rate, and other variables related to energetic capacity and efficiency have begun to shed new light on the processes that contribute to organismal performance. Thus, it is an opportune moment to bring investigators together in an organized symposium, to present their research and assess the way forward in this research. The symposium will introduce new investigators to this field, provide a forum for networking, and promote expansion of expertise in the ecological and evolutionary effects of mitochondrial function.

线粒体在确定动物性能中起着关键作用。线粒体产生几乎所有有机过程的细胞能分子，但也负责产生活性氧，进而导致氧化应激 - 这是衰老的重要促进者。结果，个体之间线粒体特性的变化可以预测生长，繁殖和衰老率的差异。尽管线粒体功能的综合度量开始提供新的见解，但与这些方法相关的理论和方法在研究界并不普遍。为了满足这一需求，将在2018年1月3日至7日在加利福尼亚州旧金山举行的综合和比较生物学协会全国会议上举行研讨会。该研讨会旨在帮助研究人员之间的网络，并扩大对线粒体功能对更广泛社区的生态和进化影响的欣赏。研讨会将包括各种各样的科学家，包括学生和博士后研究员。 被邀请的演讲者将由相等数量的男人和女人组成，这些男女的水平从大多数人到助理，同学和全部教授。互补的口头和海报会议将使研究生和本科生能够参加研讨会。主要研讨会和同伴会议中的所有演示者都将提交与他们的演讲相关的文章，该文章将在综合和比较生物学的特刊中发表。通过该出版物，主研讨会上提出的思想将被传播到更大的受众群体中，并累积地为未来的线粒体功能和生活史变化的研究提供了基础。Mitochondria在通过ATP的生产来确定生物性能方面起着至关重要的作用。 但是，它们也产生活性氧，进而产生氧化应激 - 这是衰老的重要促进者。结果，个体之间线粒体特性的变化可以预测有机物维持，生长和繁殖的差异。研究人员已开始将生物医学研究共同的线粒体功能的测量值用于生态和进化研究。此外，研究人员已经开始通过线粒体和编码线粒体蛋白的核基因之间的复杂相互作用来评估线粒体性能的遗传基础和遗传性。这些措施与氧化应激，代谢率和与能量能力和效率有关的其他变量的整合已经开始对有助于有机性能的过程进行新的启示。因此，这是将调查人员聚集在有组织的研讨会上，介绍他们的研究并评估这项研究中前进的时机。研讨会将向这一领域介绍新的研究人员，为线粒体功能的生态和进化效应提供网络的论坛，并促进专业知识的扩展。

项目成果

Life History Trade-offs within the Context of Mitochondrial Hormesis

• DOI: 10.1093/icb/icy073
• 发表时间: 2018-09-01
• 期刊: INTEGRATIVE AND COMPARATIVE BIOLOGY
• 影响因子: 2.6
• 作者: Hood, W. R.;Zhang, Y.;Kavazis, A. N.
• 通讯作者: Kavazis, A. N.

Beyond the Powerhouse: Integrating Mitonuclear Evolution, Physiology, and Theory in Comparative Biology

超越动力源：在比较生物学中整合线粒体核进化、生理学和理论

• DOI: 10.1093/icb/icz132
• 发表时间: 2019
• 期刊: Integrative and Comparative Biology
• 影响因子: 2.6
• 作者: Havird, Justin C.;Weaver, Ryan J.;Milani, Liliana;Ghiselli, Fabrizio;Greenway, Ryan;Ramsey, Adam J.;Jimenez, Ana G.;Dowling, Damian K.;Hood, Wendy R.;Montooth, Kristi L.
• 通讯作者: Montooth, Kristi L.