CAREER: Bioinspired Adaptively Reconfigurable Material Systems for Programmable and Autonomous Metal Ion Separations

职业：用于可编程和自主金属离子分离的仿生自适应可重构材料系统

• 批准号: 1724526
• 负责人: Ximin He
• 金额: $ 49.22万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1724526&HistoricalAwards=false
• 关键词: CAREER; Bioinspired; Adaptively; Reconfigurable; Material; CAREER; Bioinspired; Adaptively; Reconfigurable; Material

CAREER 1552690 - HeThe efficient extraction of molecules from fluid mixtures is vital for applications ranging from chemical analysis in water treatment to toxic or rare metal removal and recovery. Current methods for this rely on multi-step and high energy consumption operations. Inspired by the efficiency of biological separation processes that seamlessly capture and transport selective biomolecules, this project seeks to achieve a concerted "catch and release" of target molecules from a liquid mixture using responsive polymer-based material systems. The innovation arises from the programmed one-step sorting with low turnaround times. The modular design of the hybrid material system is highly customizable owing to its broad choice of chemistries, tunable mechanics, and physical simplicity. This project's career development plan provides the foundation for a long-term research program in highly efficient capture and isolation of molecules in flowing fluids. Ultimately, this technology platform may lead to the next-generation in-line separation, sensing, and monitoring technologies and be translated into broader areas of smart technology, robotics, bioengineering, and other autonomous systems. A variety of integrated research and educational activities are planned to develop bioinspired engineering curriculum by integrating the research and online media at the K-12, undergraduate, and graduate levels and to increase public awareness of bioinspired technologies and their societal impacts.The goal of this research is to apply the bioinspired strategy that seamlessly separates biomolecules in a single step to innovate adaptively reconfigurable material systems based on stimuli-responsive hydrogels and to realize continuous "catch and release" of target molecules from a liquid mixture. This research explores fundamental questions of molecular binding affinity in different chemical environments that would facilitate the discovery of new adsorbents. To assess the separation performance of the system, quantitative sorting efficiency evaluation, system robustness examination with amenability to multiple separation cycles, and optimization will be conducted. Practically, the systems encompass significant modularity and design flexibility to permit integration and upscaling for broad applications. This research integrates the disciplines of chemistry, materials, and chemical engineering. Diverse education and outreach activities are planned to promote research, education, and awareness related to bioinspired engineering and separation research fields. These include the development of a bioinspired engineering course on campus integrated with an online channel, and female undergraduate, graduate, and K-12 students participation in the research project, using existing infrastructure in the ASU High School Summer Academy, the Fulton Undergraduate Research Initiative program, and public media.

职业1552690-从流体混合物中有效提取分子对于从水处理化学分析到有毒或稀有金属去除和恢复至关重要。当前的方法依赖于多步骤和高能量消耗操作。受到无缝捕获和运输选择性生物分子的生物分离过程的效率的启发，该项目旨在使用基于响应的聚合物材料系统从液体混合物中实现靶分子的一致“捕获和释放”。创新是由编程的单步分类引起的，周转时间较低。混合物质系统的模块化设计是高度可定制的，这是由于其化学，可调力学和物理简单性的广泛选择。该项目的职业发展计划为长期研究计划奠定了基础，以高效地捕获和隔离流体流体分子。最终，这个技术平台可能会导致下一代内分离，感应和监视技术，并将其转化为智能技术，机器人技术，生物工程和其他自治系统的更广泛领域。计划通过整合K-12，本科生和研究生水平的研究和在线媒体来开发各种综合研究和教育活动，以开发生物启发的工程课程，并提高公众对生物启发的技术及其社会影响的认识。基于刺激反应性水凝胶，并实现液体混合物中靶分子的连续“捕获和释放”。这项研究探讨了在不同化学环境中分子结合亲和力的基本问题，这将有助于发现新的吸附剂。为了评估系统的分离性能，将进行定量排序效率评估，系统鲁棒性检查具有对多个分离循环的能力，并将进行优化。实际上，这些系统涵盖了重要的模块化和设计灵活性，以允许对广泛应用的集成和升级。这项研究整合了化学，材料和化学工程的学科。计划进行多种教育和外展活动，以促进与生物启发的工程和分离研究领域有关的研究，教育和意识。其中包括开发与在线渠道集成的校园内的生物启发的工程课程，以及使用ASU高中暑期学院的现有基础设施，富尔顿大学大学生研究计划和公共媒体的女性本科生，研究生和K-12学生的参与研究项目。