Multidimensional Materials Assembled by DNA Based Information

基于 DNA 的信息组装的多维材料

基本信息

批准号：
1708776
负责人：
Nadrian Seeman
金额：
$ 46.5万
依托单位：
New York University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1708776&HistoricalAwards=false
关键词：
Multidimensional Materials Assembled DNA Based

项目摘要

This award is funded by the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry. Professors Nadrian C. Seeman, and James W. Canary of New York University are supported to develop novel self-assembly approaches for controlling the orientation of polymer strands in confined spaces. The polymeric material will be directed to assemble based on information contained in pre-programmed branched-DNA scaffolds. The polymer strands are incorporated within the scaffolds with specified orientation and spacing to generate specific optical and electronic properties. Polymer-based organic materials have a wide range of practical applications, including in optical, electronic and solar energy conversion devices. Their properties depend not only on the chemical structure of the polymer, but also on the orientation of the polymer strands. Graduate and undergraduate students are trained in an interdisciplinary area of research. In addition, technical and educational activities are directed towards high school and college science students especially from underrepresented minorities. The project aims to develop a general strategy to organize conjugated oligomers and polymers by combining organic synthesis with pre-programmed DNA self-assembly. Specifically, this research investigates the incorporation of two types of semiconducting conjugated molecules -- oligopolyaniline (PANI) and poly- (p-phenylene vinylene) (PPV) -- in cage-like DNA nanoscale scaffolds and studies their elecrto-optical properties. The key experimental features are to control the length of the oligomers through stepwise organic synthesis and to covalently attached the oligomers to DNA strands. The general strategy is not limited to PANI and PPV; it can be applied to other oligomers with different electro-optical properties, as well as to fluorescent dyes, nanoparticles, and functional peptides. Study of how DNA scaffolds can be used to direct the assembly of these conjugated molecules is expected to provide insightful fundamental information about their structure/function relationships, which could eventually lead to new types of functional materials.

该奖项由化学部的大分子，超分子和纳米化学计划资助。纳德里安·C·西南（Nadrian C. 聚合物材料将根据预先编程的分支DNA支架中包含的信息进行聚集。聚合物链掺入具有指定方向和间距的支架中，以生成特定的光学和电子特性。基于聚合物的有机材料具有广泛的实用应用，包括光学，电子和太阳能转换设备。它们的特性不仅取决于聚合物的化学结构，还取决于聚合物链的方向。研究生和本科生在研究的跨学科领域接受培训。此外，技术和教育活动是针对高中和大学科学专业的学生，尤其是来自代表性不足的少数民族。该项目旨在制定一种一般策略，通过将有机合成与预编程的DNA自组装相结合来组织共轭的低聚物和聚合物。具体而言，这项研究调查了两种类型的半导体共轭分子 - 寡苯胺（PANI）和聚（P-苯基乙烯基）（PPV） - 纳入笼子样的DNA纳米级支架中，并研究其elecrto-ptiptial特性。关键的实验特征是通过逐步有机合成来控制低聚物的长度，并共价连接到DNA链上。一般策略不仅限于PANI和PPV；它可以应用于具有不同电光特性以及荧光染料，纳米颗粒和功能性肽的其他低聚物。预计如何使用DNA支架来指导这些共轭分子的组装将提供有关其结构/功能关系的有见地的基本信息，这最终可能导致新型的功能材料。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Construction of a DNA Origami Based Molecular Electro-optical Modulator

基于 DNA 折纸的分子电光调制器的构建

DOI：
10.1021/acs.nanolett.8b00332
发表时间：
2018
期刊：
Nano Letters
影响因子：
10.8
作者：
Wang, Xiao;Li, Chen;Niu, Dong;Sha, Ruojie;Seeman, Nadrian C.;Canary, James W.
通讯作者：
Canary, James W.

Orienting an Organic Semiconductor into DNA 3D Arrays by Covalent Bonds

通过共价键将有机半导体定向到 DNA 3D 阵列中

DOI：
10.1002/anie.202115155
发表时间：
2021
期刊：
Angewandte Chemie International Edition
影响因子：
0
作者：
Wang, Xiao;Deshmukh, Rahul;Sha, Ruojie;Birktoft, Jens J.;Menon, Vinod;Seeman, Nadrian C.;Canary, James W.
通讯作者：
Canary, James W.

Organizing End-Site-Specific SWCNTs in Specific Loci Using DNA