SI2-SSI Collaborative Research: The SimCardio Open Source Multi-Physics Cardiac Modeling Package

SI2-SSI 协作研究：SimCardio 开源多物理场心脏建模包

基本信息

批准号：
1663671
负责人：
Alison Marsden
金额：
$ 143.12万
依托单位：
Stanford University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1663671&HistoricalAwards=false
关键词：
SI2 SSI Collaborative Research SimCardio

项目摘要

Cardiovascular (CV) simulations have become a crucial component of fundamental research in surgical planning, device design, diagnosis, and disease mechanisms. The project team has previously developed SimVascular (www.simvascular.org), which is currently the only open source software package providing a complete pipeline from medical image data segmentation to patient specific blood flow simulation and analysis in arteries and veins. The SimCardio open source project will extend and enhance the functionality of SimVascular to the realm of heart modeling, providing the first fully integrated computer model of cardiac physiology and function. This will help basic science and medical researchers perform computer modeling in numerous diseases affecting heart function in children and adults. This computer modeling software will enable researchers to build models of the heart and vascular anatomy directly from medical imaging data, which can be used for personalized treatment planning and medical device design, ultimately leading to new treatments for patients with cardiovascular disease. The SimCardio project will create a unique open source software package for multi-physics cardiac modeling and simulations. SimCardio will include a new multi-physics finite element solver with capabilities for large-deformation fluid-structure interaction (FSI) to capture ventricular contraction and heart valve dynamics, non-linear and visco-elastic material models, cardiac mechanics models of active heart contraction, and electrophysiology. This will be facilitated by sustainable software infrastructure bridging the cardiovascular fluid and solid mechanics communities. The project will provide a new user-interface for high-throughput construction of patient-specific cardiac and vascular models. SimCardio will broaden the applicability of SimVascular to problems including heart valves, heart failure, cardiomyopathy, aortic dissection, structural congenital heart defects and medical devices. To facilitate adoption, the project will publicly provide accompanying educational and training materials, and maintain a sustainable software ecosystem to increase the user community and ensure continued availability and evolution.

心血管（CV）模拟已成为手术规划、设备设计、诊断和疾病机制基础研究的重要组成部分。该项目团队此前开发了SimVascular (www.simangio.org)，它是目前唯一的开源软件包，提供从医学图像数据分割到患者特定动脉和静脉血流模拟和分析的完整流程。 SimCardio 开源项目将 SimVasular 的功能扩展和增强到心脏建模领域，提供第一个完全集成的心脏生理学和功能计算机模型。这将帮助基础科学和医学研究人员对影响儿童和成人心脏功能的多种疾病进行计算机建模。该计算机建模软件将使研究人员能够直接根据医学成像数据构建心脏和血管解剖模型，该模型可用于个性化治疗计划和医疗设备设计，最终为心血管疾病患者带来新的治疗方法。 SimCardio 项目将为多物理心脏建模和模拟创建一个独特的开源软件包。 SimCardio 将包括一个新的多物理场有限元求解器，具有大变形流固耦合 (FSI) 功能，以捕获心室收缩和心脏瓣膜动力学、非线性和粘弹性材料模型、主动心脏收缩的心脏力学模型和电生理学。连接心血管流体和固体力学社区的可持续软件基础设施将促进这一点。该项目将为患者特异性心脏和血管模型的高通量构建提供新的用户界面。 SimCardio 将扩大 SimVascular 的适用范围，解决包括心脏瓣膜、心力衰竭、心肌病、主动脉夹层、结构性先天性心脏缺陷和医疗设备在内的问题。为了促进采用，该项目将公开提供随附的教育和培训材料，并维护可持续的软件生态系统，以扩大用户社区并确保持续的可用性和发展。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

svFSI: A Multiphysics Package for Integrated CardiacModeling

svFSI：用于集成心脏建模的多物理场软件包

DOI：
10.21105/joss.04118
发表时间：
2022
期刊：
Journal of Open Source Software
影响因子：
0
作者：
Zhu, Chi;Vedula, Vijay;Parker, Dave;Wilson, Nathan;Shadden, Shawn;Marsden, Alison
通讯作者：
Marsden, Alison

svMorph: Interactive Geometry-Editing Tools for Virtual Patient-Specific Vascular Anatomies