STTR Phase I: Multipass Sensing for Ultrahigh Resolution Particle Characterization

STTR 第一阶段：用于超高分辨率颗粒表征的多通道传感

• 批准号: 1648790
• 负责人: Anna Schibel
• 金额: $ 22.5万
• 依托单位: Electronic Bio Sciences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1648790&HistoricalAwards=false
• 关键词: STTR; Phase; Multipass; Sensing; Ultrahigh

This Small Business Technology Transfer Phase I project will generate a new nanoparticle characterization system with the ability to assess the size, length-to-width ratio, zeta potential, and concentration of solution-based nanoparticle (or molecular) samples with state-of-the-art accuracy, precision, and resolution, all on a single platform. The primary need for new nanoparticle characterization instrumentation is driven by the increasing utility and benefit of nanoparticles in healthcare and medicine, including nanoparticle drug delivery, nanoscale particle/molecule drugs and therapies, and nanoparticle-based imaging and diagnostics agents. The prototype system developed under this program will be targeted toward the general nanoparticle characterization market, presently estimated at ~$500M, which includes applications in the pharmaceutical and biomedical industries, nanoparticle manufacturing, R&D, and academic research. The developed system will not only improve solution-based nanoparticle characterization, but streamline characterization processes and provide new insights with regard to sample characterization, optimization, and utilization within the nanoparticle field.The intellectual merit of this project lies in the development of a completely new and innovative particle characterization system for which there is no equivalent, capable of automated, high-resolution, solution-based particle assessments at the single-molecule level. The developed system will enable the ability to quickly characterize a large number (hundreds to thousands) of particles/molecules in solution in order to assess the distribution within the sample. These goals will be reached by developing, building, and validating a complete and fully functioning alpha-prototype system and then demonstrating the functionality and utility of the new system by characterizing solution-based particle- and molecule-containing samples that otherwise cannot be characterized with high resolution. Upon completing this program, an entirely new nanoparticle characterization instrument will be developed and validated that is ready for initial introductions into the nanoparticle field via industrial and academic communities.

这个小型企业技术转移阶段I项目将生成一个新的纳米颗粒表征系统，能够评估具有最先进的准确性，精度和分辨率的基于溶液的纳米颗粒（或分子）样品的尺寸，ZETA电位和浓度。新纳米颗粒表征仪器的主要需求是由纳米颗粒在医疗保健和医学中的效用和益处的增加驱动的，包括纳米颗粒药物递送，纳米级颗粒/分子药物和疗法以及基于纳米粒子的成像和诊断药物。根据该计划开发的原型系统将针对一般的纳米颗粒表征市场，目前估计约为5亿美元，其中包括药品和生物医学行业，纳米颗粒制造，研发和学术研究的应用。开发的系统不仅将改善基于解决方案的纳米颗粒表征，还可以简化表征过程，并提供有关纳米颗粒字段内的样本表征，优化和利用方面的新见解。该项目的智力优点在于开发全新的和创新的粒子表征系统，该系统没有等效的粒子层次级别的自动化级别，因此可以自动化的，基于求解的层次级别，以高分为基础的元素级别，以高分为基础的元素。 开发的系统将使能够快速表征溶液中的​​大量颗粒/分子，以评估样品中的分布。通过开发，构建和验证完整且功能齐全的Alpha-Prototype系统，然后通过表征基于解决方案的粒子和分子的样品来实现这些目标的功能和实用性来实现这些目标，从而实现新系统的功能和实用性来实现这些目标。完成该计划后，将开发和验证一种全新的纳米颗粒表征工具，并可以通过工业和学术社区进行初步介绍到纳米粒子领域。