STTR Phase I: fMRI Dynamic Phantom for Improved Detection of Resting-State Brain Networks

STTR 第一阶段：用于改进静息态大脑网络检测的 fMRI 动态体模

• 批准号: 1622525
• 负责人: Alan Kriegstein
• 金额: $ 22.5万
• 依托单位: ALA Scientific Instruments, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1622525&HistoricalAwards=false
• 关键词: STTR; Phase; fMRI; Dynamic; Phantom

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to dramatically improve the detection sensitivity of resting-state fMRI. In recent years, large-scale ($150M- $1.2B USD) and long-term (10-12 year) international investments (e.g., NIH Human Connectome Project, White House BRAIN Initiative, UK Biobank, EU Human Brain Project) have expanded the reach of human fMRI to include faster pulse sequences and more complex analytic tools, higher field strength, integration with multi-scale experiments and modeling, and an emphasis on integration of data across multiple scanner/study sites. This generation of fMRI studies goes beyond the original simplistic models that focused upon activation maps, to investigate connections, networks, and dynamic nonlinear circuits in the brain. New ways of thinking are being applied to some of our highest-impact areas of societal interest, ranging from clinical depression, addiction, autism, and brain injury, to age-based cognitive degeneration. However, while fMRI research dramatically accelerates, quality assurance protocols for the MRI machines needed to generate these findings have lagged far behind, relying upon static phantom protocols no longer fully capable of targeting quality control issues relevant to current and emerging applications. The Stony Brook Dynamic Phantom is designed to address this urgent need. The proposed project builds upon a 1st generation working prototype of the dynamic phantom (patent pending), to develop engineering improvements in the 2nd generation prototype necessary to increase its durability and reliability in preparation for commercialization. The six objectives addressed in Phase I are associated with increasing precision, accuracy, reliability/reproducibility, and usability from the perspectives of both the phantom's hardware and software.

这一小型企业技术转移（STTR）I阶段项目的更广泛的影响/商业潜力是显着提高静止状态fMRI的检测灵敏度。 In recent years, large-scale ($150M- $1.2B USD) and long-term (10-12 year) international investments (e.g., NIH Human Connectome Project, White House BRAIN Initiative, UK Biobank, EU Human Brain Project) have expanded the reach of human fMRI to include faster pulse sequences and more complex analytic tools, higher field strength, integration with multi-scale experiments and modeling, and an emphasis on integration of data across多个扫描仪/研究地点。这一一代功能磁共振成像的研究超出了集中在激活图上的原始简单模型，以研究大脑中的连接，网络和动态非线性电路。新的思维方式正在应用于我们一些社会兴趣最大的影响领域，从临床抑郁，成瘾，自闭症和脑损伤到基于年龄的认知退化。但是，尽管功能磁共振成像的研究大大加速，但依靠静态幻像协议不再能够完全针对与当前和新兴应用相关的质量控制问题，因此需要为这些发现的MRI机器制定的质量保证协议远远落后了。 Stony Brook Dynamic Phantom旨在满足这种迫切需求。拟议的项目建立在动态幻影的第一代工作原型（专利待定）的基础上，以开发第二代原型的工程改进，以提高其耐用性和可靠性以准备商业化。从幻影的硬件和软件的角度来看，第一阶段中解决的六个目标与提高精度，准确性，可靠性/可重复性以及可用性相关。