PFI:AIR - TT: RestEaze: Accessible Measures of Leg Movements during Rest and Sleep

PFI:AIR - TT：RestEaze：休息和睡眠期间腿部运动的无障碍测量

• 批准号: 1601999
• 负责人: Nilanjan Banerjee
• 金额: $ 20万
• 依托单位: University of Maryland Baltimore County
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2017-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1601999&HistoricalAwards=false
• 关键词: PFI; AIR; TT; RestEaze; Accessible

This PFI: AIR Technology Translation project focuses on translating a fully functional prototype for RestEaZe, a leg-worn device comprising capacitive and inertial sensors to distinguish between general leg movements (GLM) and periodic leg movements (PLM) during sleep. These leg movements can be associated with a variety of medical conditions including restless leg syndrome (RLS), attention deficit hyperactive disorder (ADHD) and insomnia, which collectively affect millions of adults and children. RestEaZe is an in-home sleep monitoring product that will give the user an immediate, scientifically accurate view of quiet vs. restless sleep, and changes in sleep, over several nights along with professionally developed interactive guides for improving sleep based on the RestEaZe results. The doctor will get advanced movement and sleep analyses with interactive graphic and numeric summaries of the patient's sleep over several days. There is currently no easily used at-home way to measure PLM, GLM and sleep/leg position. Leg movements in sleep divide into two phenotypes: General Leg movements during Sleep (GLM) are defined by actual leg movements and periodic leg movements of Sleep (PLM) are defined by periodic dorsiflexion of the foot at the ankle. GLM patterns reveal texture and severity for sleep-behavioral intervention and in this project GLM characteristics are related to arousal risk (GLMA); PLM reveal possible medical conditions such as restless legs syndrome (RLS), cardiac morbidity and REM (rapid eye movement) behavior disorder. PLM, GLM and GLMA along with sleep position will be used to develop metrics for PLM/hr, sleep time, wake during sleep and quiet vs. restless (fragmented) sleep to support evaluations and treatments. To address this technology gap, this project is developing and commercializing a novel system, RestEaZe that identifies GLM (leg movements), PLMS (foot flexions), and leg position using a single point measurement system in a home setting. Specifically, this project combines a flexible proprietary ankle band developed at the University of Maryland, Baltimore County, with proprietary PLM analytics developed at Johns Hopkins University. RestEaZe will be an enabling technology for identifying sleep status, evaluating treatments, e.g. oral iron, behavior therapy, RLS medications, and identifying possible medical conditions. The graduate students involved in the project will be exposed to a start up like environment where milestones have to be met within strict time limits. They will also participate in presentations and demonstrations that the faculty researchers will have during events such as the Technology Breakfast (an event where entrepreneurs demonstrate their prototypes in Baltimore), exposing them to the world of entrepreneurship and commercialization.

此 PFI：AIR 技术翻译项目的重点是翻译 RestEaZe 的全功能原型，RestEaZe 是一种腿戴式设备，包含电容式传感器和惯性传感器，用于区分睡眠期间的一般腿部运动 (GLM) 和周期性腿部运动 (PLM)。这些腿部运动可能与多种疾病有关，包括不宁腿综合征 (RLS)、注意力缺陷多动障碍 (ADHD) 和失眠，这些疾病共同影响着数百万成人和儿童。 RestEaZe 是一款家用睡眠监测产品，可让用户立即、科学地准确了解安静睡眠与不安定睡眠以及几个晚上的睡眠变化，并根据 RestEaZe 结果专业开发用于改善睡眠的交互式指南。医生将获得先进的运动和睡眠分析，以及患者几天睡眠的交互式图形和数字摘要。目前还没有易于使用的家庭方法来测量 PLM、GLM 和睡眠/腿部位置。睡眠中的腿部运动分为两种表型：睡眠期间的一般腿部运动（GLM）由实际腿部运动定义，而睡眠中的周期性腿部运动（PLM）由脚踝处的周期性背屈定义。 GLM 模式揭示了睡眠行为干预的性质和严重程度，在该项目中，GLM 特征与觉醒风险 (GLMA) 相关； PLM 揭示了可能的健康状况，例如不宁腿综合症 (RLS)、心脏病和 REM（快速眼动）行为障碍。 PLM、GLM 和 GLMA 以及睡眠位置将用于制定 PLM/小时、睡眠时间、睡眠期间觉醒以及安静与不安（碎片）睡眠的指标，以支持评估和治疗。 为了解决这一技术差距，该项目正在开发一种新颖的系统 RestEaZe 并将其商业化，该系统可在家庭环境中使用单点测量系统识别 GLM（腿部运动）、PLMS（足部弯曲）和腿部位置。具体来说，该项目结合了巴尔的摩县马里兰大学开发的灵活专有踝带与约翰·霍普金斯大学开发的专有 PLM 分析技术。 RestEaZe 将成为一种用于识别睡眠状态、评估治疗方法的支持技术，例如睡眠治疗。口服铁剂、行为疗法、RLS 药物以及识别可能的健康状况。 参与该项目的研究生将接触到类似初创企业的环境，必须在严格的时间限制内达到里程碑。他们还将参加教师研究人员在技术早餐（企业家在巴尔的摩展示其原型的活动）等活动期间进行的演示和演示，让他们接触创业和商业化的世界。