Enhancing the Performance of High Performance Liquid Chromatography and Mass Spectrometry Using Nanofibers

使用纳米纤维提高高效液相色谱和质谱的性能

• 批准号: 1610254
• 负责人: Susan Olesik
• 金额: $ 54.5万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1610254&HistoricalAwards=false
• 关键词: Enhancing; Performance; Liquid; Chromatography; Mass

This project is funded by the Chemical Measurement & Imaging Program of the Chemistry Division at the National Science Foundation. Professor Susan Olesik of the Ohio State University is developing analysis methods with the ability to detect compounds at low concentration levels with improved analysis time compared to current capabilities. Increasing challenges in this country such as the need to monitor low levels of pollutants in natural waters and the need for fast clinical and forensic analyses may be impacted by this work. The broader impacts of this work include the potential societal benefits from the discoveries of the carbon based stationary phases as well as, middle school student and teacher engagement in active science projects developed from this research.This project focuses on liquid chromatography-mass spectrometric methods with increased kinetic performance, improved sensitivity, and unique selectivity. There are four project goals. First, a carbon based open tubular liquid chromatographic methods is being developed. Second, a carbon based packed liquid chromatographic column is being studied and developed. Third, the mechanism of nanofiber-based surface assisted laser desorption ionization are studied. Fourth, nanofiber based planar chromatography that is compatible with middle school studies are developed and added to a new active-learning, science outreach program for local middle schools.

该项目由国家科学基金会化学部的化学测量与成像计划资助。俄亥俄州立大学的苏珊·奥尔西克（Susan Olesik）教授正在开发分析方法，与当前能力相比，可以在低浓度水平下检测化合物并改善分析时间。这项工作可能会影响这个国家的日益增长的挑战，例如需要监测自然水域中低水平的污染物以及对快速临床和法医分析的需求。这项工作的更广泛影响包括基于碳的固定阶段的发现以及中学生和教师参与从这项研究开发的活跃科学项目的潜在社会利益。该项目着重于液态色谱 - 质谱方法，并具有提高动力学性能，提高性能，提高灵敏度和独特的选择性。有四个项目目标。首先，正在开发一种基于碳的开放管状液态色谱法。其次，正在研究和开发一个基于碳的填充液相色谱柱。第三，研究了基于纳米纤维的表面辅助激光解离电离的机制。开发了与中学研究兼容的第四个基于纳米纤维的平面色谱法，并添加到了新的活跃学习的当地中学科学外展计划中。