SHF: Medium: Collaborative Research: Materials authentication using nuclear quadrupole resonance spectroscopy

SHF：媒介：合作研究：使用核四极共振光谱进行材料认证

基本信息

批准号：
1563924
负责人：
Swarup Bhunia
金额：
$ 40万
依托单位：
University of Florida
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-15 至 2023-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1563924&HistoricalAwards=false
关键词：
SHF Medium Collaborative Research Materials

项目摘要

Counterfeit and substandard pharmaceuticals, dietary supplements, and food items containing extremely harmful contaminants have emerged as a major problem worldwide for the health industry. High-value items such as packaged medicines, which are often sold online through untrusted supply chains, are particularly prone to fraud. This project aims to develop and test novel low-cost materials authentication techniques that would enable end users to easily and reliably verify the chemical composition of medicines and dietary supplements. The widespread adoption of the proposed authentication technology could have an impact on public health by significantly enhancing the security of the supply chain for pharmaceutical and food products. The proposed authentication approach is based on comparing the Nuclear Quadrupole Resonance (NQR) spectra generated by the material under test with reference spectra stored in a secure database. The atoms of about half of all the elements in the periodic table contain so-called quadrupolar nuclei that generate NQR signals. This project will focus on the spectra of nitrogen, which is found in a large majority of pharmaceutical products. The NQR spectra are highly sensitive to chemical composition and physical properties, and thus act as unique "chemical fingerprints" that are difficult to emulate or falsify. Low power portable electronics and an integrated system resulting in instrumentation for noninvasive, nondestructive and quantitative testing will be developed for combining sensing, software, and data collection/analysis.

含有极其有害污染物的假冒伪劣药品、膳食补充剂和食品已成为全球健康行业的一个主要问题。包装药品等高价值物品通常通过不受信任的供应链在网上销售，特别容易发生欺诈。该项目旨在开发和测试新型低成本材料认证技术，使最终用户能够轻松可靠地验证药物和膳食补充剂的化学成分。拟议的认证技术的广泛采用可能会显着增强药品和食品供应链的安全性，从而对公共健康产生影响。所提出的认证方法基于将被测材料生成的核四极共振（NQR）光谱与存储在安全数据库中的参考光谱进行比较。周期表中大约一半元素的原子含有所谓的四极核，可以产生 NQR 信号。该项目将重点关注大多数药品中存在的氮的光谱。 NQR 光谱对化学成分和物理性质高度敏感，因此可以作为难以模拟或伪造的独特“化学指纹”。将开发低功耗便携式电子产品和集成系统，从而产生用于非侵入性、非破坏性和定量测试的仪器，以将传感、软件和数据收集/分析结合起来。