CAREER: Self-Assembly of Zwitterionic Amphiphilic Copolymers for Membranes with Sharp, Tunable Pore Size

职业：用于具有尖锐、可调孔径的膜的两性离子两亲共聚物的自组装

• 批准号: 1553661
• 负责人: Ayse Asatekin
• 金额: $ 50.36万
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1553661&HistoricalAwards=false
• 关键词: CAREER; Self; Assembly; Zwitterionic; Amphiphilic

CAREER 1553661-Asatekin.Membrane filtration is energy efficient, simple, scalable, and a key technology for generating clean, safe water and for preventing water pollution. Most commercially available membranes are composed of a handful of polymers, and are limited in the types of separations they can perform. This project aims to build an integrated research and education plan centered on developing novel membranes with new capabilities by designing polymers that self-assemble to form nanostructures. Specifically, this research will focus on controlling the pore size of a novel family of membranes with high flux, exceptional fouling resistance, and sharp size-based selectivity, prepared by coating zwitterion-containing amphiphilic copolymers on porous supports. This research will lead to the development of improved membranes for separations underserved by existing technologies such as peptide separations and textile wastewater treatment. It will create a link between polymer structure and membrane performance that will enable the rational design of membrane materials for specific applications. The research will be fully integrated with a system of educational activities through the involvement of students at multiple stages in developing and performing outreach activities on polymer science and separations. The team will work closely with Tufts Center for Engineering Education and Outreach (CEEO) to develop new outreach activities for K-12 students. The activity ideas will be initiated as term projects in the PI's courses for undergraduate and graduate students. They will be tested in summer workshops for girls in Malden, MA and also implemented in local schools through the Tufts Student Teacher Outreach Mentorship Program (STOMP), and disseminated through the STOMP Network. This project aims to build an integrated research and education plan centered on designing polymeric materials that self-assemble into functional nanostructures that lead to the desired membrane functionality (e.g. selectivity, fouling resistance), and on discovering fundamental relationships that correlate polymer chemistry and architecture, self-assembled nanostructure, and function in membrane applications. The specific research objective of this project is to understand how the chemical structure and molecular architecture of copolymers with hydrophobic and zwitterionic groups, and their processing methods, affect (1) their self-assembled nanostructure and (2) their performance as membrane materials in selective separations. The team aims to control the pore size of these membranes by varying the polymer architecture and processing, and to develop fundamental structure-property-function relationships that serve as design rules for polymeric membrane materials with tunable, precise and monodispersed pore size. For this purpose, the team will synthesize amphiphilic copolymers that combine hydrophobic and zwitterionic monomers in random, comb and star-block architectures. How these materials self-assemble will be studied by transmission electron microscopy (TEM) and X-ray scattering. Membranes will be made by coating porous supports with these polymers, and the pore size will be determined by filtration experiments. The pore size, permeability and fouling resistance of membranes will be correlated with the self-assembled morphology. The results will be used to compile design rules or a toolkit for the rational design of membrane materials targeted at specific separations that derive their permeability, selectivity and fouling resistance from their self-assembled structure. The research will be fully integrated with several educational, outreach and mentorship activities, such as the development of outreach activities for K-12 students that introduce concepts in polymer science, self-assembly and separations, incorporation of proposed research into undergraduate lab courses and classes, and involvement of undergraduate students in research.

职业生涯 15536​​61-Asatekin。膜过滤节能、简单、可扩展，是产生清洁、安全水和防止水污染的关键技术。大多数市售膜由几种聚合物组成，并且它们可以执行的分离类型受到限制。该项目旨在建立一个综合研究和教育计划，重点是通过设计可自组装形成纳米结构的聚合物来开发具有新功能的新型膜。具体来说，这项研究将集中于控制新型膜系列的孔径，这些膜具有高通量、出色的抗污染性和基于尺寸的敏锐选择性，这些膜是通过在多孔载体上涂覆含两性离子的两亲性共聚物而制备的。这项研究将促进改进膜的开发，用于现有技术（如肽分离和纺织废水处理）服务不足的分离。它将在聚合物结构和膜性能之间建立联系，从而能够针对特定应用合理设计膜材料。该研究将通过学生在多个阶段参与开发和开展有关聚合物科学和分离的推广活动，与教育活动系统完全整合。该团队将与塔夫茨工程教育和外展中心 (CEEO) 密切合作，为 K-12 学生开发新的外展活动。这些活动创意将作为 PI 本科生和研究生课程的学期项目启动。它们将在马萨诸塞州马尔登针对女孩的夏季研讨会上进行测试，并通过塔夫茨学生教师外展指导计划 (STOMP) 在当地学校实施，并通过 STOMP 网络进行传播。该项目旨在建立一个综合研究和教育计划，重点是设计可自组装成功能性纳米结构的聚合物材料，从而实现所需的膜功能（例如选择性、防污性），并发现与聚合物化学和结构相关的基本关系，自组装纳米结构，并在膜应用中发挥作用。该项目的具体研究目标是了解具有疏水性和两性离子基团的共聚物的化学结构和分子结构及其加工方法如何影响（1）它们的自组装纳米结构和（2）它们作为选择性膜材料的性能。分离。该团队的目标是通过改变聚合物结构和加工来控制这些膜的孔径，并开发基本的结构-性能-功能关系，作为具有可调、精确和单分散孔径的聚合物膜材料的设计规则。为此，该团队将合成以无规、梳状和星形嵌段结构结合疏水性和两性离子单体的两亲性共聚物。这些材料如何自组装将通过透射电子显微镜 (TEM) 和 X 射线散射进行研究。膜将通过用这些聚合物涂覆多孔支撑物来制成，并且孔径将通过过滤实验确定。膜的孔径、渗透性和抗污染性将与自组装形态相关。研究结果将用于编制设计规则或工具包，用于针对特定分离的膜材料的合理设计，这些膜材料从其自组装结构中获得渗透性、选择性和抗污染性。该研究将与多项教育、外展和指导活动充分结合，例如为 K-12 学生开展外展活动，介绍聚合物科学、自组装和分离的概念，将拟议的研究纳入本科生实验室课程和课堂，以及本科生参与研究的情况。

项目成果

Selective Transport through Membranes with Charged Nanochannels Formed by Scalable Self-Assembly of Random Copolymer Micelles

通过具有带电纳米通道的膜的选择性传输，该纳米通道是由无规共聚物胶束的可扩展自组装形成的

• DOI: 10.1021/acsnano.7b07596
• 发表时间: 2018-01
• 期刊: ACS Nano
• 影响因子: 17.1
• 作者: Sadeghi, Ilin;Kronenberg, Jacob;Asatekin, Ayse
• 通讯作者: Asatekin, Ayse

Membranes with Thin Hydrogel Selective Layers Containing Viral-Templated Palladium Nanoparticles for the Catalytic Reduction of Cr(VI) to Cr(III)

• DOI: 10.1021/acsanm.9b01099
• 发表时间: 2019-07-31
• 期刊: ACS Applied Nano Materials
• 影响因子: 5.9
• 作者: Ilin Sadeghi;E. Liu;H. Yi;A. Asatekin
• 通讯作者: A. Asatekin

Controlling and Expanding the Selectivity of Filtration Membranes

控制和扩大过滤膜的选择性

• DOI: 10.1021/acs.chemmater.8b03334
• 发表时间: 2018-10
• 期刊: Chemistry of Materials
• 影响因子: 8.6
• 作者: Sadeghi, Ilin;Kaner, Papatya;Asatekin, Ayse
• 通讯作者: Asatekin, Ayse

High Flux Membranes with Ultrathin Zwitterionic Copolymer Selective Layers with ∼1 nm Pores Using an Ionic Liquid Cosolvent

使用离子液体共溶剂制备具有孔径≤1 nm 的超薄两性离子共聚物选择性层的高通量膜

• DOI: 10.1021/acsapm.9b00409
• 发表时间: 2019-07
• 期刊: ACS Applied Polymer Materials
• 影响因子: 5
• 作者: Bengani;Sadeghi, Ilin;Lounder, Samuel J.;Panzer, Matthew J.;Asatekin, Ayse
• 通讯作者: Asatekin, Ayse

Spontaneous Self-Assembly and Micellization of Random Copolymers in Organic Solvents

无规共聚物在有机溶剂中的自发自组装和胶束化

• DOI: 10.1002/macp.201700226
• 发表时间: 2017-10
• 期刊: Macromolecular Chemistry and Physics
• 影响因子: 2.5
• 作者: Sadeghi, Ilin;Asatekin, Ayse
• 通讯作者: Asatekin, Ayse