UNS:Collaborative Research: Coded-illumination Fourier Ptychography for High-content Multimodal Imaging

UNS：合作研究：用于高内涵多模态成像的编码照明傅立叶叠印术

• 批准号: 1510077
• 负责人: Guoan Zheng
• 金额: $ 31万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1510077&HistoricalAwards=false
• 关键词: UNS; Collaborative; Research; Coded; illumination

Abstract (Collaborative)PI: Zheng, GuoanProposal:1510077PI: DiMarzio, CharlesProposal: 1510280This project will develop a new prototype microscope of ultra-high sensitivity with super-high resolution, yet with the ability to provide 3D imaging at a large field-of-view and rapid imaging.The proposal aims to develop a new type of microscopy technique, (coded-illumination Fourier ptychography), that incorporates the innovations of novel Fourier data recovery, structured illumination for tissue sectioning, multi-layer modeling, and spectrum multiplexing. Iteration across data acquisitions is used to optimize to a final image solution. Increased image dimensionality, either spectral or spatial, is a highly desired commodity. If these techniques can be made routine, then many areas of microscopy could benefit. The proposal reflects substantial outreach to women and significant educational efforts towards graduates and undergraduates..

摘要（合作）PI：郑国安提案：1510077PI：DiMarzio，Charles提案：1510280该项目将开发一种新型原型显微镜，具有超高灵敏度和超高分辨率，同时能够在大视场提供 3D 成像。该提案旨在开发一种新型显微技术（编码照明傅里叶叠层成像术），该技术融合了以下创新技术：新颖的傅里叶数据恢复、组织切片的结构化照明、多层建模和光谱复用。跨数据采集的迭代用于优化最终图像解决方案。增加图像维度（无论是光谱还是空间）是人们非常渴望的商品。如果这些技术能够成为常规技术，那么显微镜的许多领域都可以受益。该提案反映了对妇女的大量宣传以及对研究生和本科生的重大教育努力。

项目成果

Super-resolved multispectral lensless microscopy via angle-tilted, wavelength-multiplexed ptychographic modulation

通过角度倾斜、波长复用叠层记录调制的超分辨率多光谱无透镜显微镜

• DOI: 10.1364/ol.394923
• 发表时间: 2020-06
• 期刊: Optics Letters
• 影响因子: 3.6
• 作者: Song, Pengming;Wang, Ruihai;Zhu, Jiakai;Wang, Tianbo;Bian, Zichao;Zhang, Zibang;Hoshino, Kazunori;Murphy, Michael;Jiang, Shaowei;Guo, Chengfei;et al
• 通讯作者: et al

Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation

通过近场盲叠印调制实现宽视场、高分辨率无透镜片上显微镜

• DOI: 10.1039/c9lc01027k
• 发表时间: 2020-03
• 期刊: Lab on a Chip
• 影响因子: 6.1
• 作者: Jiang, Shaowei;Zhu, Jiakai;Song, Pengming;Guo, Chengfei;Bian, Zichao;Wang, Ruihai;Huang, Yikun;Wang, Shiyao;Zhang, He;Zheng, Guoan
• 通讯作者: Zheng, Guoan

Concept, implementations and applications of Fourier ptychography

傅立叶叠印术的概念、实现和应用

• DOI: 10.1038/s42254-021-00280-y
• 发表时间: 2021-02-10
• 期刊: Nature Reviews Physics
• 影响因子: 38.5
• 作者: G. Zheng;Cheng Shen;Shaowei Jiang;Pengming Song;Changhuei Yang
• 通讯作者: Changhuei Yang

Transform- and multi-domain deep learning for single-frame rapid autofocusing in whole slide imaging

用于全幻灯片成像中单帧快速自动对焦的变换和多域深度学习

• DOI: 10.1364/boe.9.001601
• 发表时间: 2018-03
• 期刊: Biomedical Optics Express
• 影响因子: 3.4
• 作者: Jiang, Shaowei;Liao, Jun;Bian, Zichao;Guo, Kaikai;Zhang, Yongbing;Zheng, Guoan
• 通讯作者: Zheng, Guoan

Rapid focus map surveying for whole slide imaging with continuous sample motion

通过连续样本运动进行整个载玻片成像的快速焦点图测量

• DOI: 10.1364/ol.42.003379
• 发表时间: 2017-08
• 期刊: Optics Letters
• 影响因子: 3.6
• 作者: Liao, Jun;Jiang, Yutong;Bian, Zichao;Mahrou, Bahareh;Nambiar, Aparna;Magsam, Alexander W.;Guo, Kaikai;Wang, Shiyao;Cho, Yong ku;Zheng, Guoan
• 通讯作者: Zheng, Guoan