UNS:GOALI: Collaborative Research: Aquatic Fate and Toxicity of III-V Materials in the Presence of Nanoparticles Used in Industrial Polishing Processes

UNS:GOALI：合作研究：工业抛光过程中使用的纳米粒子存在下 III-V 族材料的水生命运和毒性

• 批准号: 1507750
• 负责人: Paul Westerhoff
• 金额: $ 16.73万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1507750&HistoricalAwards=false
• 关键词: UNS; GOALI; Collaborative; Research; Aquatic

Sierra-Alvarez, Reyes (Principal investigator), The University of Arizona, Tucson, ArizonaWesterhoff, Paul (Co-principal investigator), Arizona State University, Tempe, ArizonaSpeed, David (Co-principal investigator), IBM CorporationThe growing application of III-V materials (e.g. gallium indium arsenide) in semiconductor and electronics manufacturing is expected to lead to generation of large volumes of wastewaters containing III-V metals (arsenic (As), gallium (Ga) and indium (In)) and metal oxide nanoparticles (SiO2, Al2O3 and CeO2). The potential that these engineered nanoparticles (NPs) may act as carriers of toxic III-V species and modify the reactivity of the NPs themselves is a concern. This project aims to quantify the adsorption of III-V materials by NPs and explore how these interactions impact the environmental fate, biological uptake, and aquatic toxicity of III-V species and NPs. This research will be conducted in collaboration with the semiconductor industry, a major user of SiO2, Al2O3, and CeO2 NPs, that is launching extensive R&D efforts to develop a new class of integrated circuit devices that will employ III-V semiconductors.Research work will be conducted to: i) determine new equilibrium aqueous complexation constants for In, Ga, and As with NPs and simulate the speciation and distribution of III-V elements in the presence of NPs; ii) demonstrate experimentally and through quantum calculations that sorption of III-V ions on NPs alters their surface reactivity and potential to produce reactive oxygen species, a marker commonly associated with increased cytotoxicity; and iii) understand the impact of III-V species?NP interactions on the toxicity and uptake of these emerging contaminants by model aquatic organisms. Work supported by industry will assess the fate and impact of a binary mixture of NPs and III-V ions during on-site water treatment and downstream municipal wastewater treatment. The primary intellectual merit of this project is the exploration of the central hypothesis that NPs can act as a ?Trojan Horse? of adsorbed III-V species, and thereby affect the surface reactivity and toxicity of NPs, as well as the biological uptake, fate and toxicity of the dissolved III-V metals in the aquatic environment. Whereas the concept of using NPs as Trojan Horse delivery systems for biomedical applications has attracted wide research attention, there are few realistic studies of this concept using environmentally relevant ions and NPs. Also it is well established that some NP can adsorb environmental contaminants, but the notion that adsorbed metals can alter the reactivity of NPs is novel. The study will also improve our understanding about the environmental chemistry, fate and ecotoxicity of Ga and In, two poorly characterized metals which have increasing risk to enter water systems because of their expanding industrial uses. This project will be among the first to conduct in depth experimental and modeling work of NPs in industrial waste streams.Safe development of nanotechnology is a major theme on both UA and ASU campuses and this research will contribute to expand the broader impacts associated with nanotechnology development at both institutions. The project will have benefits in education by supporting graduate student research and providing scientific results to develop modules in environmental engineering courses. Other key impacts include the development of best practice guidelines that can be used by industry to reduce the potential environmental impact of semiconductor effluents containing NPs, including effluents from planarization of III-V films. Overall, the research could benefit society by providing new knowledge and tools to facilitate assessment of potential hazards of NPs and III-V metals in the aquatic environment. Findings from this study will be made publicly available in scientific publications and presentations at scientific conferences, and they will be presented at professional meetings organized by the semiconductor industry.

塞拉 - 阿尔瓦雷斯，雷耶斯（首席研究员），亚利桑那大学，图森大学，亚利桑那州亚利桑那州，保罗（联合竞选研究员），亚利桑那州立大学，坦佩，亚利桑那州，戴维·戴维（联合省级研究员），IBM公司，III-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II-II” v半导体和电子制造中的V材料（例如，砷化甘氨酸）预计将导致含有IIII-V金属（砷（AS），甘油（GA）和indim（ga）和金属氧化物纳米颗粒（ SIO2，Al2O3和CEO2）。这些工程纳米颗粒（NP）的潜力可能充当有毒III-V物种的载体并改变NPS本身的反应性。该项目旨在通过NP量化III-V材料的吸附，并探讨这些相互作用如何影响III-V物种和NP的环境命运，生物学摄取和水生毒性。这项研究将与SIO2，AL2O3和CEO2 NP的主要用户与半导体行业合作进行，该行业正在启动广泛的研发工作，以开发新的集成电路设备，这些设备将采用IIII-V半导体。进行以下操作：i）确定in，ga以及与NP一样的新平衡水络合常数，并在NPS存在下模拟III-V元素的物种和分布； ii）通过实验并通过量子计算证明III-V离子在NP上的吸附改变了其表面反应性并产生活性氧，这是一种与细胞毒性增加有关的标志物； iii）了解III-V物种相互作用对模型水生生物对这些新兴污染物的毒性和摄取的影响。行业支持的工作将评估现场水处理和下游市政废水处理期间NP和III-V离子二元混合物的命运和影响。该项目的主要知识分子是对NP可以充当特洛伊木马的中心假设的探索？吸附的III-V物种，从而影响NP的表面反应性和毒性，以及在水生环境中溶解的III-V金属的生物摄取，命运和毒性。尽管将NP用作特洛伊木马传递系统用于生物医学应用的概念吸引了广泛的研究注意力，但使用环境相关的离子和NP对此概念几乎没有现实的研究。同样，有些NP可以吸附环境污染物，但是吸附金属可以改变NP的反应性的概念是新颖的。这项研究还将提高我们对GA的环境化学，命运和生态毒性以及两种特征性不佳的金属的理解，这些金属由于其不断扩大而进入水系统的风险增加。该项目将是最早在工业废物流中进行深入实验和建模工作的项目之一。纳米技术的安全开发是UA和ASU校园的主要主题，这项研究将有助于扩大与纳米技术开发相关的广泛影响在两个机构。该项目将通过支持研究生的研究并提供科学成果来开发环境工程课程中的模块，从而在教育方面受益。其他关键影响包括制定最佳实践指南，行业可以使用这些准则来减少含有NP的半导体流出物的潜在环境影响，包括III-V膜平面化的废水。总体而言，这项研究可以通过提供新知识和工具来促进水生环境中NPS和III-V金属的潜在危害来使社会受益。这项研究的发现将在科学会议上公开提供在科学出版物和演讲中，并将在半导体行业组织的专业会议上进行介绍。