Collaborative Research: Injectable, Biocompatible, Programmed-Bioresorbable Nanosensor Array for In-Vivo Continuous Glucose Monitoring

合作研究：用于体内连续血糖监测的可注射、生物相容性、程序化生物可吸收纳米传感器阵列

• 批准号: 1506966
• 负责人: Hanchen Huang
• 金额: $ 9.7万
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1506966&HistoricalAwards=false
• 关键词: Collaborative; Research; Injectable; Biocompatible; Programmed

Diabetes is a metabolic disorder and major world health problem. As stated by the International Diabetes Federation, there are over 350 million diabetics worldwide causing over 3.2 million deaths annually. Consequently, glucose detection is of paramount importance in the diagnosis and treatment of diabetes. This project will illustrate how nanotechnology, biomaterials, and biosensing technologies can be meshed together for injectable, biocompatible, bioresorbable nanosensor array for continuous glucose monitoring. The work will advance in vitro and/or in vivo monitoring technology for continuous glucose monitoring in general and, if successful, will not only have an enormous impact on public health, but also provide a demonstration from basic science to applications. This project will impact education of the graduate, undergraduate and high school students by integrating advanced biosensing into their educational and laboratory training, and actively interact with the general public and industry companies through various outreach activities within and outside of the University of Connecticut and Northeastern University. Moreover, a new course of Bioanalytical Sensor will be offered to students. This multidisciplinary proposal aims to develop an injectable biocompatible and programmed-bioresorbable surface-enhanced Raman scattering sensor for long-term, subcutaneous, continuous glucose monitoring. A number of novel features crossing bio-, nano-, material- and sensing technologies will be seamlessly meshed into this novel glucose sensing system. A sandwich-like glucose sensing material, including programmed-bioresorbable glucose-responsive nanosensor array covered by biocompatible and biodegradable hydrogel with entrapped anti-inflammatory drug, will be fabricated. Then a sterilized indwelling needle will be used to deliver the as-prepared sensor subcutaneously for long-term, continuous glucose sensing. The sensing performance will be systematically investigated. The synergistic effects of (1) good biocompatibility and biodegradability of hydrogel, together with (2) good biocompatibility and stability of nanosensor array, (3) programmable bioresorbability of sensing materials after long-term use, (4) specific and reversible binding of glucose with sensing material and its unique and strong glucose-responsive optical signals distinguishable from those of skin tissue and hydrogel, (5) non-invasive monitoring through Raman scattering, (6) anti-inflammatory effect provided by anti-inflammatory drug entrapped in hydrogel, and (7) minimally invasive delivery of sensor through convenient skin piercing, will accomplish the goal of reliable long-term continuous glucose monitoring.

糖尿病是一种代谢障碍和重大的世界健康问题。正如国际糖尿病联合会所说的那样，全球有超过3.5亿糖尿病患者每年造成超过320万人死亡。因此，葡萄糖检测对于糖尿病的诊断和治疗至关重要。该项目将说明如何将纳米技术，生物材料和生物传感技术融合在一起，以进行注射，生物相容性，可生物可吸收的纳米传感器阵列，以进行连续葡萄糖监测。这项工作将在体外和/或体内监测技术中进步，以进行连续的葡萄糖监测，如果成功的话，不仅会对公共卫生产生巨大影响，而且还提供了基础科学的演示。该项目将通过将高级生物传感纳入其教育和实验室培训，并通过康涅狄格大学和东北大学的各种外展活动与公共和行业公司积极互动，从而影响研究生，本科和高中生的教育。此外，还将向学生提供新的生物分析传感器。该多学科的建议旨在开发可长期，皮下，连续的葡萄糖监测的可注射可注射的生物相容性和编程的表面增强拉曼散射传感器。跨越生物，纳米，材料和传感技术的许多新型特征将无缝地融合到这个新型的葡萄糖传感系统中。将制造一种类似三明治的葡萄糖传感材料，包括可生物相容性和可生物降解的水凝胶覆盖的可覆盖的葡萄糖响应性纳米传感器阵列，并制造出滞留的抗炎药。然后，将使用灭菌的留置针可用于皮下递送制备的传感器，以长期连续的葡萄糖感应。感应性能将被系统地研究。 The synergistic effects of (1) good biocompatibility and biodegradability of hydrogel, together with (2) good biocompatibility and stability of nanosensor array, (3) programmable bioresorbability of sensing materials after long-term use, (4) specific and reversible binding of glucose with sensing material and its unique and strong glucose-responsive optical signals distinguishable from those of skin tissue and水凝胶，（5）通过拉曼散射进行非侵入性监测，（6）滞留在水凝胶中提供的抗炎药提供的抗炎作用，（7）（7）通过方便的皮肤穿孔将传感器微创递送，将实现可靠的可靠的长期长期连续连续糖监测的目标。