UNS: Employing hydrodynamic lift and particle trajectory ratcheting to achieve sieve-free separations based on size and shape in cross-flow filtration

UNS：利用流体动力升力和颗粒轨迹棘轮，在错流过滤中根据尺寸和形状实现无筛分离

基本信息

批准号：
1505795
负责人：
Donald Koch
金额：
$ 30.9万
依托单位：
Cornell University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2019-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1505795&HistoricalAwards=false
关键词：
UNS Employing hydrodynamic lift particle

项目摘要

1505795(Koch)The focus of the proposed research is to study particle transport phenomena that occur during cross-flow filtration of suspensions. In addition to development of fundamental understanding of these phenomena, the objective is to aid the development of a so-called sieve-free filtration system. While the proposed work is highly fundamental, engineering applications are its motivation.This is a proposal to conduct a combined theoretical/numerical/experimental study of particle separation in crossflow. The motivation for this study is to improve practices in cross-flow filtration - a high throughput method of separating particles (including cells or macromolecules) from a fluid and from smaller sized particles. In conventional operation, the separation is accomplished by sieving through a membrane with a small pore size. The PI argues, and the panel agreed that this is worth exploring, that an operation in which the separation is accomplished using particulate hydrodynamic transport processes rather than membrane exclusion would have the advantages of decreasing membrane fouling and improving the selectivity of the separation. Because of the high shear rates accessible in cross-flow filtration, inertial lift can keep the particles away from the coarse non-sieving membrane. In addition, a new sieve-free separation mechanism based on the ratcheting of particle trajectories at the rough surface of the membrane due to excluded volume interactions of the particle with the membrane will be investigated. The goal is to develop a predictive model for lift-based cross-flow, allowing separation based on shape as well as size and identifying the maximum filtration flux and particle concentration at which particles can be retained. This mechanism can lead to sieve-free separations of nanoparticles or proteins which are too small to separate based on hydrodynamic lift. The models developed will be tested and the reliability of sieve-free filtration demonstrated by experimental measurements of separation of micro- and nano-particles of well controlled size and shape in a Couette cell filter. In addition to graduate education, plans to reach out to K-12 students and by an experimental demonstration to be used in activities at the local children's museum and the Ithaca Science Center are laid out.

1505795（Koch）拟议研究的重点是研究悬浮液错流过滤过程中发生的颗粒传输现象。除了发展对这些现象的基本理解之外，目标是帮助开发所谓的无筛过滤系统。虽然所提出的工作具有很强的基础性，但工程应用是其动机。这是一项对横流中颗粒分离进行综合理论/数值/实验研究的建议。这项研究的动机是改进错流过滤的实践，错流过滤是一种从流体和较小尺寸颗粒中分离颗粒（包括细胞或大分子）的高通量方法。在常规操作中，分离是通过小孔径的膜进行筛分来完成的。 PI 认为，并且专家组也认为这是值得探讨的，使用颗粒流体动力传输过程而不是膜排除来完成分离的操作将具有减少膜污染和提高分离选择性的优点。由于错流过滤可实现高剪切速率，惯性升力可以使颗粒远离粗的非筛分膜。此外，还将研究一种新的无筛分离机制，该机制基于由于颗粒与膜排除的体积相互作用而在膜粗糙表面处的颗粒轨迹棘轮。目标是开发基于升力的横流的预测模型，允许根据形状和尺寸进行分离，并确定可以保留颗粒的最大过滤通量和颗粒浓度。这种机制可以实现纳米颗粒或蛋白质的无筛分离，因为纳米颗粒或蛋白质太小而无法基于流体动力升力进行分离。将测试开发的模型，并通过在库埃特细胞过滤器中对尺寸和形状良好控制的微米和纳米颗粒的分离进行实验测量来证明无筛过滤的可靠性。除了研究生教育外，还计划向 K-12 学生提供服务，并在当地儿童博物馆和伊萨卡科学中心的活动中进行实验演示。