Collaborative Research: Fate, Transport, and Organismal Uptake of Rod-Shaped Nanomaterials

合作研究：棒状纳米材料的命运、运输和生物摄取

• 批准号: 1440261
• 负责人: Navid Saleh
• 金额: $ 11.9万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1440261&HistoricalAwards=false
• 关键词: Collaborative; Research; Fate; Transport; Organismal

CBET 1336353There is currently very little known about the environmental implications of rigid highly anisotropic nanostructures. Nanorods possessing high aspect ratios (AR = length:diameter) are an exciting nanomaterial class with many potential applications. To date, however, only a limited number of studies have examined the environmental fate of these elongated nanomaterials. The lack of work in this area is particularly surprising given that it has been definitively shown that anisotropy affects how nanorods interact with biological systems. The underlying hypothesis driving the present effort is that changes in AR and surface chemistry will alter the mechanisms and kinetics dictating nanorod fate in riverine systems. To test this hypothesis the PIs have developed a research plan that consists of four highly inter-related project tasks: In Task 1 we will synthesize gold nanorods with varying AR and we will then functionalize them using a range of environmentally relevant metal oxides (e.g., SiO2, gamma-Fe2O3, CeO2) to obtain a suite of nanomaterials that exhibit both shape and surface chemical heterogeneity. These nanorods will then be used in studies to evaluate nanorod aggregation (Task 2), nanorod deposition (Task 3), and uptake by the filter feeding bivalve Corbicula fluminea (Task 4). Completion of each of these tasks is an important undertaking in its own right; however, we have developed a cohesive research plan in which the knowledge gained in any one task is used to help refine the overall research plan.Intellectual Merit :Anisotropic nanoparticles are being produced in an ever-expanding variety of shapes and sizes in ever-increasing quantities. Presently ery little is known about the environmental implications of these highly complex nanomaterials. The effort proposed herein will provide a fundamental basis for the description of how material anisotropy dictates nanomaterial fate in environmental matrices. The expected intellectual outcomes of this effort are i) systematic examination of nanorod aggregation kinetics and fractal dimension as a function of aspect ratio and solution chemistry (ii) delineation of deposition mechanisms by the systematic variation of particle properties (AR, surface chemistry) and collector parameters (e.g., collector size and surface roughness) in column studies; and (iii) quantification of the effects of AR on nanomaterial uptake by the ubiquitous filter feeder C. fluminea. Although our focus is on gold and gold-core nanorods, the results obtained are expected to be translatable to other anisotropic materials. Broader Impacts :A multi-dimensional approach to broader impacts has been developed. This approach leverages existing programs at the three collaborating institutions while working to integrate efforts across the groups. Research dissemination and outreach. The PIs will collectively promote and disseminate the research results through existing community programs in Virginia, South Carolina, and Illinois. In addition, the results of this project will be broadcast to a broad technical audience through the traditional pathways of peer-reviewed publications and presentations at relevant conferences. Outreach efforts will target minority students in local high schools. Undergraduate research. Undergraduate research opportunities will be made available at all three collaborating institutions. Over the course of their careers, the PIs have collectively supported over 90 undergraduate researchersin their laboratories (a significant percentage of whom are members of historically under-represented groups in science and engineering) and this effort will provide additional undergraduate research opportunities. Undergraduate and graduate education. The research proposed in this effort combines nanomaterial synthesis and characterization techniques with colloidal physical principles in a manner that is not routinely found in undergraduate chemistry or environmental engineering curricula. Given this fact, all three PIs will take part in the development and production of classroom material (e.g., lectures, demonstrations) based upon this research that will be incorporated into courses at all three institutions.

CBET 1336353 目前，人们对刚性高度各向异性纳米结构的环境影响知之甚少。具有高纵横比（AR = 长度:直径）的纳米棒是一类令人兴奋的纳米材料，具有许多潜在的应用。然而，迄今为止，只有有限数量的研究调查了这些细长纳米材料的环境命运。鉴于已明确表明各向异性影响纳米棒与生物系统的相互作用，该领域缺乏工作尤其令人惊讶。推动当前努力的基本假设是，AR和表面化学的变化将改变决定河流系统中纳米棒命运的机制和动力学。为了检验这一假设，PI 制定了一项研究计划，其中包括四个高度相关的项目任务：在任务 1 中，我们将合成具有不同 AR 的金纳米棒，然后使用一系列与环境相关的金属氧化物（例如， SiO2、γ-Fe2O3、CeO2）以获得一组表现出形状和表面化学异质性的纳米材料。然后，这些纳米棒将用于评估纳米棒聚集（任务 2）、纳米棒沉积（任务 3）以及滤食双壳类河蚬的吸收（任务 4）的研究。完成这些任务中的每一项本身就是一项重要任务；然而，我们制定了一个有凝聚力的研究计划，其中在任何一项任务中获得的知识都用于帮助完善整个研究计划。 智力优点：各向异性纳米粒子的形状和尺寸不断扩大，产量不断增加数量。目前，人们对这些高度复杂的纳米材料对环境的影响知之甚少。本文提出的努力将为描述材料各向异性如何决定纳米材料在环境基质中的命运提供基础基础。这项工作的预期成果是：i) 系统地研究纳米棒聚集动力学和分形维数与纵横比和溶液化学的函数关系；(ii) 通过颗粒特性（AR、表面化学）和收集器的系统变化来描述沉积机制色谱柱研究中的参数（例如收集器尺寸和表面粗糙度）； (iii) 量化 AR 对无处不在的滤食动物 C. Fluminea 吸收纳米材料的影响。尽管我们的重点是金和金核纳米棒，但所获得的结果预计可以转化为其他各向异性材料。更广泛的影响：已经开发出一种能够产生更广泛影响的多维方法。这种方法利用三个合作机构的现有计划，同时努力整合各小组的努力。研究传播和推广。 PI 将通过弗吉尼亚州、南卡罗来纳州和伊利诺伊州的现有社区项目共同推广和传播研究成果。此外，该项目的成果将通过同行评审出版物和相关会议上的演讲等传统途径向广​​大技术受众传播。外展工作将针对当地高中的少数族裔学生。本科生研究。 所有三个合作机构都将提供本科生研究机会。在他们的职业生涯中，PI 共同支持了实验室的 90 多名本科生研究人员（其中很大一部分是历史上代表性不足的科学和工程群体的成员），这一努力将提供额外的本科生研究机会。本科和研究生教育。这项工作提出的研究将纳米材料合成和表征技术与胶体物理原理相结合，其方式在本科化学或环境工程课程中并不常见。鉴于这一事实，所有三个 PI 将参与基于这项研究的课堂材料（例如讲座、演示）的开发和制作，这些材料将纳入所有三个机构的课程中。