Forecasting the Environmental Fate and Ecotoxicity of Nanomaterials in Aquatic Systems

预测水生系统中纳米材料的环境归趋和生态毒性

• 批准号: 1438165
• 负责人: Stacey Harper
• 金额: $ 30.74万
• 依托单位: Oregon State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1438165&HistoricalAwards=false
• 关键词: Forecasting; Environmental; Fate; Ecotoxicity; Nanomaterials

Proposal Number: CBET - 1438165Nano-size particles (nanoparticles, or NPs) are increasingly prevalent in industrial processes. Their toxic effects are usually not known before their use. The Oregon State University research team proposes to develop small-scale ("nanocosm") assays to profile the eco-toxicities of NPs in an aquatic environment. Students from minority and woman groups will be involved in the proposed research. The results of the development and investigation will shed light on the behavior of silver and zinc oxide NPs in aquatic environments. Since the lack of a common approach to environmental investigations of NPs has limited the advancement of knowledge in this area, the successful outcomes from this proposal can be adopted as a standard technique by other researchers, policy makers and regulators, and chemical producers, and the proposed research is, therefore, potentially transformative. The overall goal of the proposed work is to predict nanomaterial behavior in natural environments and forecast potential to impact organisms and ecosystem function. The objectives of the proposal plan is to first develop and validate an assay for use in determining the ecotoxicity of nanomaterials in aquatic systems by using small-scale studies of algae, bacteria, small invertebrates, and developing vertebrates in order to determine the biological impacts of known nanomaterial toxicants (Ag and ZnO nanoparticles). The validated assay will then be employed to elucidate nanomaterial features (e,g, composition, size, and surface chemistry) that alter bioavailability, biological impacts, community structure and overall ecosystem health across diverse nanomaterials. Finally, the data gathered will be used to help construct a predictive model using the structure-activity relationships (SAR) of nanoparticle behavior and ecotoxicity. The results will be established and embedded into existing modeling frameworks that can translate the findings to decision making processes. This, in turn, will help provide protocols for designing future nanocosms.

提案编号：CBET - 1438165 纳米尺寸颗粒（纳米颗粒或 NP）在工业过程中越来越普遍。它们的毒性作用在使用前通常是未知的。俄勒冈州立大学研究小组提议开发小规模（“纳米宇宙”）检测方法来分析纳米颗粒在水生环境中的生态毒性。来自少数族裔和女性群体的学生将参与拟议的研究。开发和研究的结果将揭示银和氧化锌纳米颗粒在水生环境中的行为。由于缺乏通用的纳米粒子环境调查方法限制了该领域知识的进步，因此该提案的成功结果可以被其他研究人员、政策制定者和监管者以及化学品生产商采用作为标准技术，并且因此，拟议的研究具有潜在的变革性。拟议工作的总体目标是预测自然环境中的纳米材料行为并预测影响生物体和生态系统功能的潜力。该提案计划的目标是首先开发和验证一种测定方法，通过对藻类、细菌、小型无脊椎动物和发育中的脊椎动物进行小规模研究，确定水生系统中纳米材料的生态毒性，以确定纳米材料的生物影响。已知的纳米材料有毒物质（Ag 和 ZnO 纳米颗粒）。然后，经过验证的测定将用于阐明改变不同纳米材料的生物利用度、生物影响、群落结构和整体生态系统健康的纳米材料特征（例如成分、尺寸和表面化学）。最后，收集到的数据将用于利用纳米颗粒行为和生态毒性的构效关系（SAR）构建预测模型。结果将被建立并嵌入到现有的建模框架中，该框架可以将研究结果转化为决策过程。反过来，这将有助于提供设计未来纳米宇宙的协议。