Forecasting the Environmental Fate and Ecotoxicity of Nanomaterials in Aquatic Systems

预测水生系统中纳米材料的环境归趋和生态毒性

• 批准号: 1438165
• 负责人: Stacey Harper
• 金额: $ 30.74万
• 依托单位: Oregon State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1438165&HistoricalAwards=false
• 关键词: Forecasting; Environmental; Fate; Ecotoxicity; Nanomaterials

Proposal Number: CBET - 1438165Nano-size particles (nanoparticles, or NPs) are increasingly prevalent in industrial processes. Their toxic effects are usually not known before their use. The Oregon State University research team proposes to develop small-scale ("nanocosm") assays to profile the eco-toxicities of NPs in an aquatic environment. Students from minority and woman groups will be involved in the proposed research. The results of the development and investigation will shed light on the behavior of silver and zinc oxide NPs in aquatic environments. Since the lack of a common approach to environmental investigations of NPs has limited the advancement of knowledge in this area, the successful outcomes from this proposal can be adopted as a standard technique by other researchers, policy makers and regulators, and chemical producers, and the proposed research is, therefore, potentially transformative. The overall goal of the proposed work is to predict nanomaterial behavior in natural environments and forecast potential to impact organisms and ecosystem function. The objectives of the proposal plan is to first develop and validate an assay for use in determining the ecotoxicity of nanomaterials in aquatic systems by using small-scale studies of algae, bacteria, small invertebrates, and developing vertebrates in order to determine the biological impacts of known nanomaterial toxicants (Ag and ZnO nanoparticles). The validated assay will then be employed to elucidate nanomaterial features (e,g, composition, size, and surface chemistry) that alter bioavailability, biological impacts, community structure and overall ecosystem health across diverse nanomaterials. Finally, the data gathered will be used to help construct a predictive model using the structure-activity relationships (SAR) of nanoparticle behavior and ecotoxicity. The results will be established and embedded into existing modeling frameworks that can translate the findings to decision making processes. This, in turn, will help provide protocols for designing future nanocosms.

建议编号：CBET -1438165NANO大小的颗粒（纳米颗粒或NP）在工业过程中越来越普遍。它们的毒性作用通常在使用之前不知道。俄勒冈州立大学研究小组提议开发小规模（“纳米”）测定法，以介绍水生环境中NP的生态毒性。来自少数民族和女性团体的学生将参与拟议的研究。开发和研究的结果将阐明水生环境中银和氧化锌NP的行为。由于缺乏对NP的环境调查的常见方法限制了该领域知识的进步，因此该提案的成功结果可以被其他研究人员，政策制定者和监管机构以及化学生产者和化学生产者采用，因此拟议的研究具有潜在的变革性。拟议工作的总体目标是预测自然环境中的纳米材料行为，并预测影响生物和生态系统功能的潜力。该提案计划的目标是首先开发和验证一种用于确定水生材料生态毒性的测定方法，通过使用藻类，细菌，小型无脊椎动物和开发脊椎动物的小规模研究，以及开发脊椎动物，以确定已知的纳米材料有毒物的生物学影响（AG和Zno nananopictess）。然后，将使用经过验证的测定法阐明纳米材料特征（E，G，组成，大小和表面化学），以改变各种纳米材料的生物利用度，生物学影响，社区结构和整体生态系统健康。最后，收集的数据将用于使用纳米颗粒行为和生态毒性的结构活性关系（SAR）来帮助构建预测模型。结果将建立并嵌入到现有的建模框架中，这些框架可以将发现转化为决策过程。反过来，这将有助于提供设计未来纳米颜色的协议。