EAPSI: Stimuli-responsive capsules from polymer-covered gold nanorods

EAPSI：由聚合物覆盖的金纳米棒制成的刺激响应胶囊

• 批准号: 1414688
• 负责人: Rachel Letteri
• 金额: $ 0.51万
• 依托单位: Letteri Rachel A
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1414688&HistoricalAwards=false
• 关键词: EAPSI; Stimuli; responsive; capsules; polymer

'Smart' materials that respond to external stimuli, such as a change in temperature, pH, ionic strength, light exposure, or electric field, are the subject of a large body of research for applications that range from artificial muscles to sensors to the delivery of therapeutics. This project will investigate the stimuli-responsive behavior of oil-in-water droplets stabilized by polymer-covered gold nanorods (rod-shaped nanometer-sized gold particles, Au NRs), which are responsive to temperature, salt concentration, and light. Dr. Hongwei Duan, an expert in assemblies composed of polymer-covered particles, at Nanyang Technological University in Singapore will served as the host for this research. Placing special materials, such as Au NRs and polymers, at the oil-water interface of these droplets will afford new materials that hold great promise as highly functional, responsive systems.Assembling polymer-nanoparticle composites into two- or three-dimensional structures affords properties distinct from the individual components that are broadly interesting for chemistry, physics, engineering, and biology. This project will involve the incorporation of salt- and temperature-responsive zwitterionic polymers onto Au NRs. The versatility of polymer chemistry lends itself to easily combine stimuli-responsive functional groups with moieties that facilitate cross-linking and binding to gold into the same polymer, while Au NRs are ideal components of smart materials due to their biocompatibility and inherent ability to convert light into heat. The nanocomposites will be assembled at the oil-water interface, on droplets, and subsequently cross-linked into mechanically robust capsules. The response of these assemblies to external stimuli (i.e. salt, temperature, and light) will be studied by optical microscopy and by surface enhanced Raman scattering (SERS). To demonstrate the utility of these capsules for encapsulation, the uptake and release of a dye will be monitored. This NSF EAPSI award is funded in collaboration with the National Research Foundation of Singapore.

对外部刺激有反应的“智能”材料，例如温度，pH，离子强度，光照或电场的变化，是对从人造肌肉到传感器再到治疗剂的范围的大量研究的主题。该项目将研究通过聚合物覆盖的金纳米棒（杆状纳米尺寸的金颗粒，Au nrs）稳定的水中水滴的刺激反应性，这些液滴对温度，盐浓度和光线有响应。新加坡南南技术大学的组装专家Hongwei Duan博士将担任这项研究的主持人。将特殊材料（例如AU NRS和聚合物）放置在这些液滴的油水界面上，将提供新的材料，这些材料作为高度功能，响应式的系统具有巨大的希望。将聚合物 - 纳米粒子复合材料汇总到二维或三维结构中，使其与化学，物理学，生理学，机构和生物学，物理学和生物学，物理学和生物学，物理学和生物学，物理学，机构和生物学，物理学，生理学，机构和生物学，物理学和生物学，物理学，机构和生物学，和物理学，机构和生物学，以及物理学，机构和生物学，和物理学，生理学，机构和生物学，和物理学，生理学，和物理学，和物理学，机构和生物学学的差异。该项目将涉及将盐和温度响应性的Zwitterionic聚合物掺入AU NRS。聚合物化学的多功能性使自己可以轻松地将刺激响应性官能团与部分结合起来，从而促进交联并与黄金结合到同一聚合物中，而Au nrs则是智能材料的理想组成部分，因为它们的生物相容性和固有能力将光转化为热量。纳米复合材料将在油水界面，液滴上组装，然后将其交联到机械强大的胶囊中。这些组件对外部刺激的响应（即盐，温度和光）将通过光学显微镜和表面增强的拉曼散射（SER）研究。为了证明这些胶囊封装的效用，将监测染料的摄取和释放。该NSF EAPSI奖与新加坡国家研究基金会合作。