Environmentally Responsive Supramolecular Constructs and Models for Chemical Communication

用于化学通讯的环境响应性超分子结构和模型

• 批准号: 1402004
• 负责人: Jonathan Sessler
• 金额: $ 45万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1402004&HistoricalAwards=false
• 关键词: Environmentally; Responsive; Supramolecular; Constructs; Models

With this award from the Macromolecular, Supramolecular and Nanochemistry Program, Jonathan L. Sessler of The University of Texas is carrying out research aimed at creating new systems that can communicate chemically. Living systems are unique in their ability to communicate by purely chemical means and a wide array of new technologies could become possible if we were able to mimic this behavior. Chemical communication in living systems can occur over short distances, which is what happens when brain cells communicate by the release and capture of neurotransmitter molecules. Or, the communication can take place over large distances, such as when insects, or even some mammals, communicate by releasing pheromones. Although these processes are well known in the world of biology, it has not yet been possible to reproduce this type of communication in an artificial system. In this work, the investigators are doing just that, using sophisticated laboratory methods they have developed to accomplish molecular design and construction in a controlled fashion. This work will likely impact the development of possible new information systems. New approaches to artificial intelligence and wireless communication may become possible as a result of this fundamental research. The work is having a further broad impact through the training of the next generation of scientists in cutting-edge laboratory techniques that will prepare the students involved in this research for work in a wide variety of technologically challenging areas.This project focuses on the use of electron rich and electron poor receptors whose features can be modulated via changes in pH, redox potential, and substrate binding. Particular emphasis is being placed on tetrathiafulvalene calixpyrrole receptors and various electron deficient substrates, including fullerene derivatives. Conformational switching, as engendered by anion binding to a calixpyrrole, for instance, is used to induce changes in equilibrium. These perturbations, in turn, serve to release small chemical species that can act as triggers for the modulation of other receptor systems, such as those built from oligopyrroles. A range of techniques, including standard spectroscopies, photochemistry, color-based reactions, and solid state crystallography is being used to characterize the systems involved in this project and the changes in their features due to induced perturbations in equilibrium behavior.

通过大分子，超分子和纳米化学计划的奖项，得克萨斯大学的乔纳森·塞斯勒（Jonathan L.生活系统在通过纯化学方法进行交流的能力上是独一无二的，如果我们能够模仿这种行为，那么多种新技术就会成为可能。生命系统中的化学通信可能会在短距离内发生，这是当脑细胞通过释放和捕获神经递质分子通信时发生的情况。或者，可以通过释放信息素进行通信，例如昆虫甚至一些哺乳动物进行通信。尽管这些过程在生物学领域是众所周知的，但尚未在人工系统中重现这种交流。在这项工作中，调查人员正在采用他们开发的复杂实验室方法来以受控方式完成分子设计和构建。这项工作可能会影响可能的新信息系统的发展。由于这项基本研究，可能成为人工智能和无线通信的新方法。这项工作是通过培训下一代科学家在最先进的实验室技术中产生的广泛影响，这将使参与这项研究的学生为在各种技术上具有挑战性的领域中的工作做好准备。该项目着重于使用Electron Rich和Electron差受体的使用，这些受体可以通过pH，REDOX电位和sidtrate Bingignigant的变化来调节其特征。特别重点放在四脂钙钙钙受体和各种电子缺乏的底物上，包括富勒烯衍生物。例如，由阴离子结合到钙吡咯的结合而产生的构象切换用于诱导平衡的变化。这些扰动反过来又有助于释放小型化学物种，这些化学物种可以充当调节其他受体系统的触发因素，例如由寡吡咯型建造的。一系列技术，包括标准光谱，光化学，基于颜色的反应和固态晶体学，以表征该项目所涉及的系统以及由于平衡行为的诱导扰动引起的特征变化。