SusChEM: Fluorinated Alkoxide Complexes of Copper for C-X Bond Forming Reactions

SusChEM：用于 C-X 键形成反应的铜的氟化醇盐配合物

• 批准号: 1362550
• 负责人: Linda Doerrer
• 金额: $ 39万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1362550&HistoricalAwards=false
• 关键词: SusChEM; Fluorinated; Alkoxide; Complexes; Copper; SusChEM; Fluorinated; Alkoxide; Complexes; Copper

This Research award in the Sustainable Chemistry, Engineering, and Materials program supports work by Professor Linda Doerrer at Boston University to develop new C-X bond forming reactions with the earth-abundant metal copper. The local impact of funding this proposal will increase the number of well-trained young scientists that can pursue education and careers in STEM fields with a particular focus on recruiting and retaining women. A new bilingual outreach program is being designed which can potentially impact many young students outside the Boston area. A wide impact on the chemical community is envisaged as this work uses Cu, an abundant and environmentally sustainable metal, to break C-H bonds, with and without O2, and make a variety of new bonds. The strategy uses copper to replace the expensive and more toxic metals currently used for these chemistries. Developing new reactions for chemical bond formation requires considering not only the desired product, but all the products formed, the energy balance of the process, as well as the overall environmental cost. Earth-abundant metals are excellent candidates for new bond forming processes. In previous work, a new family of molecules with the sustainable metals Fe, Co, Ni, and Cu was extensively developed. The metals contained ligands that are effectively teflon-coated with fluorinated groups that make them highly resistant to decomposition reactions that non-fluorinated molecules can be prey to. Two unexpected and exciting discoveries made with Cu provide an understanding for common reactions forming C-C, C-O, and C-N bonds that are being pursued. The overall impact of this work is to provide an improved understanding of materials and methods for synthesizing high value carbon-based compounds for use in numerous processes of societal relevance.

这项可持续化学，工程和材料计划的研究奖支持波士顿大学琳达·杜雷（Linda Doerrer）教授的工作，以开发新的C-X债券与土壤丰富的金属铜形成反应。资助该提案的当地影响将增加训练有素的年轻科学家的数量，这些科学家可以在STEM领域从事教育和职业，特别关注招募和保留妇女。正在设计一项新的双语外展计划，可能会影响波士顿地区以外的许多年轻学生。设想对化学界产生广泛的影响，因为这项工作使用CU，一种丰富且环保的金属，可以打破有或没有O2的C-H键，并建立各种新键。该策略使用铜来代替目前用于这些化学的昂贵且更具毒性的金属。 为化学键形成开发新的反应不仅需要考虑所需的产品，而且考虑形成的所有产品，过程的能量平衡以及整体环境成本。土壤丰富的金属是新键形成过程的出色候选者。在先前的工作中，具有可持续金属FE，CO，NI和CU的新分子家族是广泛开发的。这些金属含有配体，这些配体有效地用氟化基团包裹，这使得它们对非荧光分子可以捕食的分解反应具有高度耐药性。通过CU做出的两个意外而令人兴奋的发现为所追求的C-C，C-O和C-N键的常见反应提供了理解。这项工作的总体影响是提供对材料和方法的深入了解，以合成高价值的基于碳的化合物，以在许多社会相关性过程中使用。