EAGER: Study of Ultra-High Brightness of Fluorescent Silica Nanoparticles for the use in Bio Imaging Applications

EAGER：用于生物成像应用的超高亮度荧光二氧化硅纳米颗粒的研究

• 批准号: 1321826
• 负责人: Igor Sokolov
• 金额: $ 18.92万
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1321826&HistoricalAwards=false
• 关键词: EAGER; Study; Ultra; Brightness; Fluorescent

1242214SokolovThis EAGER proposal deals with fluorescent nanoparticles of unusually high brightness. Being a substantially new and radically different approach to making fluorescent nanoparticles, this research is considered to be high risk. At the same time, it is a high potential payoff due to the importance of such particles for a broad range of photonic applications involving tagging, tracing, labeling, and particularly in biological imaging and sensing. High brightness of labeling particles is desirable to attain higher signal-to-noise ratio, and consequently, to increase sensitivity and/or speed of sensing, contrast of imaging, to decrease the limit of detection, etc. The merits of the proposed research are in the study of silica nanoparticles, which have unusually strong fluorescent emission; understanding the nature of this phenomenon; and investigating the limits of this approach for bio-imaging applications.

1242214 Sokolovthis急切的建议涉及异常亮度的荧光纳米颗粒。作为制造荧光纳米颗粒的一种新的且根本不同的方法，这项研究被认为是高风险。同时，由于此类粒子在涉及标记，跟踪，标记，尤其是在生物学成像和传感方面的广泛光子应用中的重要性，因此这是高电位的高潜力。标记颗粒的高亮度是需要达到较高的信噪比，因此可以提高感应性和/或速度，以降低检测的限制，以降低检测的极限等。拟议的研究的优点在于二氧化硅纳米颗粒的研究，这些硅纳米颗粒具有强烈强烈的荧光荧光发射；了解这种现象的本质；并研究这种方法的生物成像应用程序的限制。