EAGER: Study of Ultra-High Brightness of Fluorescent Silica Nanoparticles for the use in Bio Imaging Applications

EAGER：用于生物成像应用的超高亮度荧光二氧化硅纳米颗粒的研究

• 批准号: 1321826
• 负责人: Igor Sokolov
• 金额: $ 18.92万
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1321826&HistoricalAwards=false
• 关键词: EAGER; Study; Ultra; Brightness; Fluorescent

1242214SokolovThis EAGER proposal deals with fluorescent nanoparticles of unusually high brightness. Being a substantially new and radically different approach to making fluorescent nanoparticles, this research is considered to be high risk. At the same time, it is a high potential payoff due to the importance of such particles for a broad range of photonic applications involving tagging, tracing, labeling, and particularly in biological imaging and sensing. High brightness of labeling particles is desirable to attain higher signal-to-noise ratio, and consequently, to increase sensitivity and/or speed of sensing, contrast of imaging, to decrease the limit of detection, etc. The merits of the proposed research are in the study of silica nanoparticles, which have unusually strong fluorescent emission; understanding the nature of this phenomenon; and investigating the limits of this approach for bio-imaging applications.

1242214Sokolov 这个 EAGER 提案涉及异常高亮度的荧光纳米粒子。作为一种全新且完全不同的荧光纳米粒子制造方法，这项研究被认为具有高风险。同时，由于此类粒子对于广泛的光子应用（包括标记、追踪、标记，特别是在生物成像和传感中）的重要性，它具有很高的潜在回报。标记颗粒的高亮度有助于获得更高的信噪比，从而提高灵敏度和/或传感速度、成像对比度、降低检测限等。本研究的优点是研究具有异常强荧光发射的二氧化硅纳米颗粒；了解这种现象的本质；并研究这种方法在生物成像应用中的局限性。