NSF East Asia and Pacific Summer Institute (EAPSI) for FY 2013 in Japan

2013 财年 NSF 东亚及太平洋夏季学院 (EAPSI) 在日本举行

• 批准号: 1310869
• 负责人: Michael Schulz
• 金额: $ 0.51万
• 依托单位: Schulz Michael D
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1310869&HistoricalAwards=false
• 关键词: NSF; East; Asia; Pacific; Summer

This action funds Michael Schulz of the University of Florida to conduct a research project in the Math and Physical Sciences area during the summer of 2013 at Kyoto University in Kyoto, Japan. The project title is "Understanding the Connection between Binding and Molecular Architecture in Polymer-Metal Mixtures." The host scientist is Yoshiki Chujo.Polyethyleneimine-methylphosphonate (PEI-MP) is an anionic polymer--a negatively charged large molecule--that has been studied as a polymeric ligand to bind to certain metals, specifically radioactivce atoms, or radionuclides. However, the binding of PEI-MP to radionuclides is not understood at a fundamental level. This project is studying various potential binding configurations of the polymer system with a simplified, small molecule system. Isothermal titration calorimetry (ITC) is being used to measure the thermodynamic parameters of each binding mode. This information provides insight into which molecular configurations form the most stable coordinate complexes, i.e., which are the most effective at binding to different metals. Understanding the binding of PEI-MP at a fundamental level will allow the rational design and improvement of future polymeric radionuclide carriers. Broader impacts of an EAPSI fellowship include providing the Fellow a first-hand research experience outside the U.S.; an introduction to the science, science policy, and scientific infrastructure of the respective location; and an orientation to the society, culture and language. These activities meet the NSF goal to educate for international collaborations early in the career of its scientists, engineers, and educators, thus ensuring a globally aware U.S. scientific workforce. Furthermore, the Fellow has demonstrated a commitment to undergraduate education, involving undergraduate students in the scientific preparation required prior to the start of the EAPSI fellowship. He will include undergraduates in new research and collaborations that result from interactions with the host scientist as well.

该行动资助佛罗里达大学的迈克尔·舒尔茨 (Michael Schulz) 于 2013 年夏季在日本京都的京都大学开展数学和物理科学领域的研究项目。 该项目的标题是“了解聚合物金属混合物中的结合和分子结构之间的联系”。主持科学家是 Yoshiki Chujo。聚乙烯亚胺-甲基膦酸酯 (PEI-MP) 是一种阴离子聚合物（一种带负电荷的大分子），已被研究作为与某些金属（特别是放射性原子或放射性核素）结合的聚合物配体。然而，PEI-MP 与放射性核素的结合尚不清楚。该项目正在研究具有简化的小分子系统的聚合物系统的各种潜在结合构型。等温滴定量热法 (ITC) 用于测量每种结合模式的热力学参数。这些信息可以深入了解哪些分子构型形成最稳定的配位复合物，即哪些分子构型在与不同金属的结合方面最有效。从根本上了解 PEI-MP 的结合将有助于合理设计和改进未来的聚合物放射性核素载体。 EAPSI 奖学金的更广泛影响包括为研究员提供美国以外的第一手研究经验；各自地点的科学、科学政策和科学基础设施的介绍；以及对社会、文化和语言的定位。 这些活动符合 NSF 的目标，即在科学家、工程师和教育工作者职业生涯的早期进行国际合作教育，从而确保美国科学劳动力具有全球意识。 此外，该研究员还表现出了对本科教育的承诺，让本科生参与 EAPSI 奖学金开始之前所需的科学准备。他还将让本科生参与新的研究和合作，这些研究和合作也是与宿主科学家互动的结果。