CREATIV: Paleodevelopmental Evolution in Echinoids

CREATIV：海胆类的古发育进化

• 批准号: 1240626
• 负责人: Isabelle Peter
• 金额: $ 80万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1240626&HistoricalAwards=false
• 关键词: CREATIV; Paleodevelopmental; Evolution; Echinoids; CREATIV; Paleodevelopmental; Evolution; Echinoids

This INSPIRE award is partially funded by the Evolution of Developmental Mechanisms Program in the Division of Integrated Organismal Systems in the Biology Directorate and by the Sedimentary Geology & Paleobiology Program in the Division of Earth Sciences in the Geology Directorate.All contemporary animal forms, including ourselves, are the result of evolution from prior forms, as demonstrated unequivocally by the fossil record. But observation of fossils cannot inform as to how changes in body plan occurred; that question can only be answered experimentally. This interdisciplinary INSPIRE project capitalizes on a unique opportunity to study the same set of divergent characters from an evolutionary structural vantage point, using fossils; and from a developmental molecular biology vantage point studying processes in living descendants of the fossil lineages. Echinoderms have left a superb fossil record stretching back more than half a billion years because of their easily fossilized skeletons, some aspects of which will be studied with 3-D digital high energy X-ray technology for this project. The developmental processes which generate the specific skeletal structures which have arisen in given branches of echinoderm evolution can now also be accessed experimentally in the laboratory. This project has the unique opportunity of providing an explanation for what actually happened in evolution, in the specific terms of changes in genetically controlled process for building bodily structure. This is among the major, fundamental questions in bioscience. If successful the outcome will indeed transform this area of biology, by demonstrating a new powerful approach to understanding, in which is combined, sophisticated observation of deep time remains, with sophisticated experimental and synthetic exploration of living descendants. The project illustrates the potential power of interdisciplinary marriage between traditionally separate areas. It will require new ways of thought and in the process, joint training and research experiences will be instituted for involved graduate students in the Division of Biology at the California Institute of Technology and in the Department of Earth Sciences at the University of Southern California. This type of multidisciplinary cross-training will produce a new breed of evolutionary scientists who will pioneer further advances in understanding the mechanisms of evolution.

该INSPIRE奖的部分资助是由生物学局综合有机系统部的发展机制计划的演变和由地质局地球科学部的沉积地质与古生物学计划进行的，包括我们自己在内的所有当代动物形式，包括先前的形式的结果，都是由现代动物形式出现的结果，是由先前的形式出现的，是由fossil coss y equocial record sevelly comply of from facsion形式的结果。但是对化石的观察无法告知身体计划的变化是如何发生的；这个问题只能通过实验回答。这种跨学科的激发项目利用了独特的机会，可以使用化石从进化的结构有利位置研究相同的不同角色。以及从化石谱系的生物后代中研究过程的发展分子生物学。由于它们易于化石的骨骼，echinoderms留下了一张出色的化石记录，延伸了十亿多年，其中某些方面将使用该项目的3-D数字高能X射线技术进行研究。现在，在实验室中也可以通过实验访问产生特定的骨骼结构的发育过程，这些过程现在也可以通过实验访问。该项目具有独特的机会，可以说明进化中实际发生的事情的解释，这是关于建立身体结构的遗传控制过程的特定术语。这是生物科学中的主要基本问题之一。如果成功的结果确实会通过展示一种新的强大理解方法来改变这一生物学领域，从而将深层观察结合在一起，以及对生命后代的复杂实验和合成的探索，对深度的深入观察仍然存在。该项目说明了传统分开的地区之间跨学科婚姻的潜在力量。它将需要新的思维方式，在此过程中，将为加利福尼亚理工学院和南加州大学地球科学系生物学系的参与研究生建立联合培训和研究经验。 这种多学科的跨训练将产生一种新的进化科学家，他们将开拓进一步的进步，以理解进化的机制。