NSF/FDA SIR: Engineered Nanomaterials in Medical Devices: Development of Immune Response Biomarkers

NSF/FDA SIR：医疗器械中的工程纳米材料：免疫反应生物标志物的开发

• 批准号: 1237451
• 负责人: Judith Zelikoff
• 金额: $ 5.1万
• 依托单位: New York University Medical Center
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1237451&HistoricalAwards=false
• 关键词: NSF; FDA; SIR; Engineered; Nanomaterials

Abstract#1237451Zelikoff, JudithThis proposal, submitted under the NSF/FDA Scholar-in-Residence at FDA Program, seeks to provide mentoring activities for an NYU postdoctoral scholar to conduct scientific research at the FDA (Center for Devices and Radiological Health) on the development/validation of immune response assays useful as early indicators for nanomaterial (NM)-induced toxicity associated with medical device applications. Use of engineered NM for medical devices is rapidly growing. Currently, silver (Ag) nanoparticles (NP) are used for medical device applications(i.e., in wound dressings and catheter coatings) to prevent infections. FDA is also faced with metal oxide NP derived as wear debris from orthopedic implants. Metal-on-metal hip replacement devices made from surgical cobalt-chromium (Co-Cr) alloy, have been shown to release Co and Cr NP by wear mechanisms into the body. Despite clinical assumptions that after the removal of worn hip replacements level of metal ions in the tissue/blood decrease, uncertainty remains about long-term health consequences of these metal particles.

摘要＃1237451zelikoff，Judiththis提案，根据NSF/FDA驻地驻地提交了FDA计划的驻地，旨在为NYU博士后学者提供指导活动，以在FDA（设备和放射性响应中心验证）的型号（NAOM）对NON的设备（NAM）进行有用的（NAM）的识别（NAM）的供应（NAM）的科学研究（NAM）进行科学研究（申请。 使用工程的NM用于医疗设备正在迅速增长。当前，银（Ag）纳米颗粒（NP）用于医疗设备应用（即在伤口敷料和导管涂层中），以防止感染。 FDA还面临着源自骨科植入物的磨损碎屑的金属氧化物NP。由手术钴铬（Co-CR）合金制成的金属金属髋关节置换设备已被证明可以通过磨损机构释放CO和CR NP。尽管临床假设是，在组织/血液减少磨损的金属离子水平后，这些金属颗粒的长期健康后果仍然存在不确定性。