MRI: Acquisition of a three-dimensional X-ray imaging system (microCT) supporting multiple users, research, and education through a central facility

MRI：获取三维 X 射线成像系统 (microCT)，通过中央设施支持多个用户、研究和教育

• 批准号: 1229417
• 负责人: Kendra Greenlee
• 金额: $ 48.28万
• 依托单位: North Dakota State University Fargo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1229417&HistoricalAwards=false
• 关键词: MRI; Acquisition; three; dimensional; ray

This Major Research Instrumentation award to North Dakota State University funds acquisition of an imaging system to examine relatively small items up to 12 inches and 25 pounds using digital radiography and computed X-ray microtomography (microCT). In addition to producing high-resolution conventional two-dimensional/flat radiographs, the system uses microCT to form multiple cross-sectional digital images of an object along a single axis. These images can be reassembled and manipulated graphically to create a three-dimensional virtual model, permitting inspection of external and internal structures without damage to the original object. There are many possibilities for subsequent analysis of the virtual model, e.g. visualization of computer-generated ?slices?, arbitrary sectional views in any desired plane, pseudo-color representations of different phases, and pore analysis. Accurate internal measurements can be made that are obtainable in no other way without destroying the sample. MicroCT provides a unique nondestructive way to visualize complex structures from the macro to micro scales. Overall system resolution now is better than 1 µm, permitting detailed understanding of characteristics of structure, composition, phase morphology, and particle distribution. Also included for specimen prep¬a¬ra¬tion is a lyophilizer or freeze-drying apparatus to remove water by sublimation and desorption, thus preserving perishable samples for imaging. Instrumentation will be housed in the NDSU Electron Microscopy Center, making it universally available for analysis to researchers in fields from Biology and Anthropology to Engineering and Chemistry as well as for teaching/training across disciplines.Through microCT, investigators will have access to nondestructive analysis that is simply impossible at NDSU now. This active, well-funded research team, which is ethnically and gender-diverse, encourages participation by members of groups that traditionally have not been not well-represented in the scientific community (e.g., women, Native Americans). In addition to research use, microCT will be an integral part of courses on nanotechnology, nanomaterials, characterization, and materials-design physics; that training will broaden career opportunities for NDSU graduates and help attract talented new faculty members. The instrumentation is expected to see immediate use as a teaching tool for inspection in Bison Microventure, an ongoing multidisciplinary course that over the past three years has provided hands-on experience integrating biology, chemistry, and engineering for undergraduate and graduate students representing eight majors from five colleges. With its versatility and ready visualization, microCT will be an attractive option for undergraduate Biotechnology students and K-20 students participating in NDSU outreach programs like the North Dakota Governor's School, NATURE program (Nurturing American Tribal Undergraduate Research and Education), state Science Olympiad, and local education collaborations. Other anticipated users include institutions throughout the North Dakota University System and industry partners across the upper Midwestern region, as no other microCT units are available within the state.

北达科他州立大学的这项主要研究仪器奖是通过数字X射线照相和计算的X射线显微图像学（Microct）来检查成像系统的资金，以检查最小12英寸和25磅的相对小物品。除了产生高分辨率的常规二维/平面X光片外，该系统还使用Microct沿单个轴形成对象的多个横截面数字图像。这些图像可以以图形方式重新组装和操纵以创建三维虚拟模型，从而允许检查外部和内部结构而不会损坏原始对象。随后分析虚拟模型有许多可能性，例如在任何所需平面，不同阶段的伪色表示和孔分析中可视化计算机生成的？切片？，任意截面视图。如果不破坏样品，就可以以其他方式获得准确的内部测量。 Microct提供了一种独特的无损方式来可视化从宏到显微镜的复杂结构。现在的整体系统分辨率优于1 µM，允许对结构，组成，相形和颗粒分布的特征的详细了解。标本准备的还包括冻干剂或冷冻干燥设备，可通过升华和解吸去除水，从而保留可腐烂的样品进行成像。仪器将安置在NDSU电子显微镜中心，使其普遍可用于分析从生物学和人类学到工程和化学的领域的研究人员，以及跨学科的教学/培训。通过Microct，研究人员将可以访问NDSU在NDSU完全不可能的非源性分析。这个活跃，资金充足的研究团队是种族和性别多样性的，鼓励了传统上从传统上没有得到很好代表的团体成员的参与（例如，妇女，美洲原住民）。除研究用途外，MicroCT将是纳米技术，纳米材料，表征和材料设计物理学课程不可或缺的一部分。该培训将扩大NDSU毕业生的职业机会，并帮助吸引有才华的新教师。预计该仪器将立即用作野牛微文学的教学工具，这是一种正在进行的多学科课程，在过去的三年中，该课程为本科和研究生的生物学，化学和工程学提供了动手经验，可为代表五所大学的八个专业的学生和研究生进行工程学。凭借其多功能性和现成的可视化，Microct将成为本科生物技术学生和K-20学生参加NDSU外展计划的有吸引力的选择，例如北达科他州州长学校，自然计划（培育美国部落本科研究和教育），州科学奥林匹克教育和地方教育合作。其他预期的用户包括整个北达科他大学系统的机构和中西部地区的行业合作伙伴，因为该州内没有其他Microct单位。